THE ACTIONS OF THE α-MELANOCYTE STIMULATING HORMONE (α-MSH) IN INFLAMMATORY CONDITIONS

Year 2001, Volume: 14 Issue: 2, 113 - 118, 03.12.2016

Berna Oktar İnci Alican

Abstract

Inflammation, a localized response to tissue injury, and disorders characterized by inflammation are difficult problems in clinical medicine. This difficulty stems in large part from incomplete understanding of inflammatory processes and their regulation. Recent development of the knowledge of the role of the central nervous system and neuroendocrine system in the host responses has provided a new view of the capacity of neuronal and soluble mediators in these systems to influence inflammation. One of these mediators is the endogenous neuropeptide a-MSH, which is an N-acetyl tridecapeptide derived from the cleavage of a larger precursor molecule, proopiomelanocortin (POMC). It was originally isolated and characterized from the intermediate lobe of the pituitary and it was first recognized by its effect on skin melanophores in lower vertebrates (1).

References

• Eberle API. The metanotropins. Basel: Barger, ¡988:1-556.
• Catania A, Lipton JM. Alpha-melanocyte stimulating hormone in the modulation of host reactions. Endocr Rev 1993;14:564-576.
• Redding TW, Rastin AJ, Rikolies R, Schally A V, Coy Dfl. Disappearance and excretion of labeled a-MSH in man. Pharmacol Biochem Behav 1978;9:207-212.
• Rhorram O, Bedran De Castro JC, McCann SM. Stress-induced secretion of a a prolactin and luteinizing hormone in the female rat. Endocrinology 1985,1 1 7:2483-2489.
• Robba C, Rebuffat P, Mazzocchi Q, Hcussdorfer OS. Long term tropic actions of a-melanocyte-stimulating hormone on the zona glomerulosa of the rat adrenal cortex. Acto Endocrinol 1986; 112:404-408.
• Chhajlani V, Wikberg JES. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDTiA. EEBS Letter 1992;309:417-420.
• Gantz I, Ronda Y, Tashiro T, et al. Molecular cloning of a melanocortin receptor. J Biol Chem 1993;268:8246-8250.
• Lipton JM, Catania A. Anti-inflammatory actions of the neuroimmunomodulator a- MSH. Immunol Today 1997,18: ¡40-145.
• Star RA, Rajora H, Huang J, Chavez R, Catania A, Lipton JM. Evidence of autocrine modulation of macrophage nitric oxide synthase by a-melanocyte-stimulating hormone. Proc Hatl Acad Sci USA 1995;92:8016-8020.
• Rajora fi, Ceriani G, Catania A, Star RA, Murphy MT, Lipton JM. a-MSH production, receptors and influence on neopterin in a human monocyte/macrophage cell line. J Leukocyte Biot 1996:59:248-253.
• Hoi EM, Gispen WH, Bar PR. ACTH-related peptides: receptors and signal transduction systems involved in their neurotropic and neuroprotective actions. Peptides 1995,16:979-993.
• Xia Y, Wikberg JES. In situ hybridization histochemical localization of ACTH receptor mRITA in mouse adrenal gland. Cell Tissue Res 1996;286:63-68.
• Catania A, Rajora Ti, Capsoni E, Minonzio E, Star RA, Lipton JM. The neuropeptide alpha- MSH has specific receptors on neutrophils and reduces chemotaxis in vitro. Peptides 1996,17:675-679.
• Adachi S, Hakano T, Vliagoftis H, Metcalfe DD. Receptor-mediated modulation of murine mast cell function by a-melanocyte stimulating hormone. J Immunol 1999; 163:3363-3368.
• Lipton JM. MSH in CHS control of fever and its
• influence on inflammation/immune responses. In: Hadley ME, ed. The
• melanotropic peptides. Baco Raton: CRC press, 1988:98-113.
• Hiltz ME, Lipton JM. Anit-inflammatory activity of a COOH- terminal fragment of the neuropeptide a-MSH. EASEB J 1989;3:2282- 2284.
• Chiao H, Poster S, Thomas R, Lipton J, Star
• RA. a-Melanocyte-stimulating hormone reduces endotoxin-induced liver
• inflammation. J Clin Invest 1996:97:2038- 2044.
• Qrabbe S, Bhardway RS, Mahnke R, Simon MM, Schwarz T, Luger TA. a-Melanocyte- stimuiating hormone induces hapten-specific tolerance in mice. J Immunol 1996; 156:473- 478.
• Ceriani G, Diaz J, Murphree S, Catania A, Lipton JM. The neuropeptide alpha- melanocyte-stimulating hormone inhibits experimental arhritis in rats. Heuroimmunomodulation 1994; 1 -.28-32.
• Lipton JM, Ceriani G, Macaluso A, et al. Antiinflammatory effects of the neuropeptide a-MSH in acute, chronic, and systemic inflammation. Ann HY Acad Sci 1994;741:137-148.
• Rajora H, Boccali G, Burns D, Sharma S, Catania AP, Lipton JM. a-MSH modulates local and circulating tumor necrosis factor-a in experimental brain inflammation. J Heurosci 1997;17:2181-2186.
• Catania A, Gerloni V, Procaccia S, et al. The anticytokine neuropeptide a-melanocyte- stimulating hormone in synovial fluid of patients with rheumatic disease: comparisons with other anticytokine molecules. Heuroimmunomodulation 1994; 1 -.321 -328.
• Airaghi L, Lettino M, Manfredi MG, Lipton JM, Catania A. Endogenous cytokine antagonists during myocardial ischemia and thrombolytic therapy. Am Heart J 1995; 130:204-211.
• Catania A, Suffredini AF, Lipton JM. Endotoxin
• causes a-MSH release in normal human subjects. Heuroimmunomodulation
• ;2:258-262.
• Catania A, Airaghi L, Manfredi MG, et al. Proopiomelanocortin-derived peptides and
• Berna K. Oktar, et al
• cytokines: relations in patients with acquired immunodePiciency syndrome. Clin Immunol Immunopathol 1993;66:73-79.
• Shih ST, Rhorram O, Lipton JM, McCann SM. Central administration of a-MS fl antiserum augments fever in the rabbit. Am J Physiol 1986;250:R803-R806.
• Lipton JM, Glyn JR. Central administration of peptides alter thermoregulation in the rabbit. Peptides 1980; 1:15-18.
• Murphy MT, Richards DB, Lipton JM. Antipyretic potency of centrally administered alpha-melanocyte-stimulating hormone. Science 1983;221:192-193.
• Robertson BA, Charing LC, Daynes RA.
• neuropeptide regulation of interleukin-1 activities: capacity of a-melanocyte
• stimulating hormone to inhibit interleukin-1 inducible responses in vivo and in vitro exhibits target cell selectivity. Inflammation 1986;10:371-385.
• Zimmer JA, Lipton JM. Central and peripheral injections of ACTfl (1-24) reduces fever in adrenalectomized rabbits. Peptides 1981;2:413-417.
• Taylor AIV, Streileln JW, Cousins SIV. Alpha- melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. ITeuroimmunomodulation 1994;1:188-194.
• Luger TA, Schauer E, Trautinger P. Production of immunosuppressing melanotrophins by human kératinocytes. Ann riY Acad Sci 1993;680:567-570.
• Aebischer l, Stampfli MR, Zurcher A, et al. neuropeptides are potent modulators of human in vitro immunoglobulin E synthesis. Eur J Immunol 1994;24:1908-1913.
• Mann SK, Aggarwal BB. a-Melanocyte stimulating hormone inhibits the nuclear factor nE-kB activation induced by various inflammatory agents. J Immunol 1998;161:2873-2877.
• Cannon JG, Tatro JB, Reichlin S, Dinarello CA. Alpha-melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin-1. J Immunol 1986; 137:2232-2236.
• Daynes RA, Robertson BA, Cho B, Burnham DR, newton R. Alpha melanocyte stimulating hormone exhibits target cell selectivity in its capacity to affect interleukin-1 inducible responses in vivo and in vitro. J Immunol 1987,139:103-109.
• liiltz ME, Catania A, Lipton JM. a-MSfl peptides inhibit acute inflammation induced in mice by rlL-lfi, rlL-6, rTRF-a and endogenous pyrogen but not that caused by LTB^, PAP and rlL-8. Cytokine 1992;4:320- 328.
• Martin LW, Deeter LB, Lipton JM. Acute-phase response to endogenous pyrogen in rabbit: effects of age and route of administration. Am J Physiol 1989;25 7-.R 189-R193.
• Chiao fl, Rohda Y, McLeroy P, Craig L, flousini I, Star RA. a-Melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats. J Clin Invest 1997;99:1165- 1172.
• Oktar BR, Ercan P, Yeğen BÇ, Alican i. The effect of alpha-melanocyte stimulating hormone on colonic inflammation in the rat. Peptides 2000;21:1271-1277.
• Rajora R, Boccoli G, Catania A, Lipton JM. a- MSfl modulates experimental inflammatory bowel disease. Peptides 1997; 18:381 -385.
• Galimberti D, Baron P, Med a L, et al. a-MSfl
• peptides inhibit production of nitric oxide and tumor necrosis factor-a by microglial cells activated with [5-amyloid and interferony. Biochem Biophys Res Commun
• ;263:251-256.
• Lipton JM, Macaluso A, fliltz ME, Catania A. Central administration of the peptide a-MSfl inhibits inflammation in the skin. Peptides 1991;12:795-798.
• Ceriani G, Macaluso A, Catania A, Lipton JM.
• Central neurogenic antiinflammatory action of a-MSH: modulation of peripheral
• inflammation induced by cytokines and other mediators of inflammation.
• Reuroendocrinology 1994;59:138-143.
• Macaluso A, McCoy D, Ceriani G, et al. Antiinflammatory influences of a-MSfl molecules: central neurogenic and peripheral actions. J Reurosci 1994;14:2377-2382.