THE RELATION BETWEEN HUMAN Y CHROMOSOME MICRODELETIONS AND SPERM MORPHOLOGY

Year 2002, Volume: 15 Issue: 4, 227 - 232, 03.12.2016

Deniz Sevinç Ahmet Zehir Anıl Biricik Semra Sertyel Semra Kahraman İlter Güney

Abstract

O b je c tiv e : Recent investigations have
supported the importance of Y chromosome
microdeletions in male infertility. Besides
different factors, sperm morphology is also a very
important component of the clinical evaluation of
male fertility potential. The aim of our study was
to understand the relation between Y
chromosome microdeletions and sperm
morphology in different risk groups.
Material and Methods: In this study, 34 infertile
men were selected and examined in terms of
sperm morphology and Y chromosome
microdeletions. Semen analyses of the patients
were performed by using Strict criteria and the
samples were grouped according to the sperm
abnormalities. Peripheral blood samples were
examined for Y chromosome microdeletions by a
multiplex polymerase chain reaction amplification
of sequence-tagged sites (STS) of the Y
chromosome.
R e su lts : The incidence of deletions in the group
was 14.7 % (5/34). The rates of Y chromosome
microdeletion were 33.3% for megalohead,
33.3% for elongehead, 0% for roundhead, 100%
for pinhead, 14.3% for severe teratozoospermia,
33.3% for severe neck abnormalities and 0% for
tail-stump Pregnancy could not be obtained from
Y chromosome deleted cases.
Co nclus io n: It seems that especially patients
with sperm head and neck abnormality have
increased microdeletion risk. It is suggested that
a detailed sperm morphology examination and
classification is needed to clarify the Y
chromosome deletion-sperm morphology relation.
Key Words: Y chromosome microdeletions,
Sperm morphology, Male infertility

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