BibTex RIS Cite

FATAL CIPROFLOXACIN-INDUCED TOXIC EPIDERMAL NECROLYSIS (LYELL SYNDROME): A CASE REPORT AND REVIEW OF THE LITERATURE

Year 2002, Volume: 15 Issue: 3, 189 - 193, 03.12.2016

Cengiz Açıkel Ersin Ülkür Bahattin Çeliköz

Abstract

Toxic epidermal necrolysis (TEN) is one of the most dramatic and severe adverse cutaneous drug reactions. Ciprofloxacin is a frequently prescribed fluoroquinolone and can induce TEN occasionally. A review of the English literature revealed 7 ciprofloxacin-associated TEN cases in the past 10 years. A well-documented fatal case of ciprofloxacin induced TEN is presented. This case report adds to the evidence that ciprofloxacin is associated with TEN in rare cases. All healthcare practitioners should be alert for signs of TEN in patients taking ciprofloxacin and discontinue the drug immediately. Because of the similarity of TEN to an extensive partialthickness burn besides multiorgan involvement or complications, transfer of the patient to a burn unit in the shortest time is vital.
Key Words : Toxic epidermal necrolysis, Ciprofloxacin, Quinolones, Adverse drug reactions.

References

  • /. Bastuji-Garin S, Rzany li. Stem RS, Shear rill, Roujeau JC. A clinical classification of cases of toxic epidermal necrolysis, Stevens- Johnson syndrome, and erythema multiforme. Arch Dermatol 1993; 129: 92-96.
  • Wolkenstein PE, Roujeau JC, Revuz J. Drug- induced toxic epidermal necrolysis. Clin Dermatol 1998; 16: 399-409.
  • Weiglitman W. Toxic epidermal necrolysis. Review. Australas J Dermatol 1996; 37: 167- I 75.
  • Roujeau JC, Kelly J, Haldi L, et at. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. H Engl J Med 1995:333: 1600-1607.
  • Saiag P, Caumes E, Chosidow O, Revuz J, Roujeau JC. Drug-Induced toxic epidermal necrolysis (Lyell syndrome) in patients infected with the human immunodeficiency virus. J Am Acad Dermatol 1992; 26: 567- 574.
  • Tham TCK, Allen G, Hayes D, McGrady li, Riddell JG. Possible association between toxic epidermal necrolysis and ciprofloxacin. Lancet 1991; 338: 522.
  • Sakellariou G, Koukoudis P, Karpouzas J, et al. Plasma exchange treatment in drug- induced toxic epidermal necrolysis. Int J Artif Organs 1991; 14: 634-638.
  • Moshfeghi M, Mandler HD. Ciprofloxacin- induced toxic epidermal necrolysis. Ann Pharmacother 1993; 27: 1467-1469.
  • Yerasi AH, Oertel MD. Ciprofloxacin-induced toxic epidermal necrolysis. Ann Pharmacother 1996; 30: 297.
  • Livasy CA, Kaplan AM. Ciprofloxacin-induced toxic epidermal necrolysis: a case report. Dermatology 1997; 195: 173-175.
  • Uppal R, Jhaj R, Malhotra S. Adverse drug reactions to fluoroquinolones at a tertiary care hospital in northern India. J /tssoc Physicians India 1998; 46: 946-947.
  • Matsuno K, Kunihiro E, Yamatoya O, et al. Surveillance of adverse reactions due to ciprofloxacin in Japan. Drugs / 995; 49 Suppl 2: 495-496.
  • Grover JK. Unwanted effects of ciprofloxacin in Indian population. Ind J Physiol Pharmacol 1993; 37: 232-234.
  • Matthews MR, Caruso DM, Phillips BJ, Csontos LG. Culminant toxic epidermal necrolysis induced by trovafloxacin. Arch Intern Med 1999; 159: 2225.
  • Roujeau JC, Albengres E, Moritz S, et al. Lymphocyte transformation test in drug- induced toxic epidermal necrolysis. Int Arch Allergy Appl Immunol 1985; 78: 22-24.
  • Wolkenstein P, Chosidow O, Flechet ML, et al. Patch testing in severe cutaneous adverse drug reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Contact Dermatitis 1996; 35: 234-236.
  • I 7. Guillaume JC, Roujeau JC, Revuz J, Penso D, Touraine R. The culpit drugs in 87 cases of toxic epidermal necrolysis (Lyell's syndrome). Arch Dermatol 1987; 123: 1166-1 170.
  • Garcia-Doval I, LeCleach L, Bocquet H, Otero XL, Roujeau JC. Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death? Arch Dermatol 2000; 136: 323- 327.
  • Becker DS. Toxic epidermal necrolysis. Lancet 1998; 351: 1417-1420.
  • Stern RS. Improving the outcome of patients with toxic epidermal necrolysis and Stevens- Johnson syndrome. Arch Dermatol 2000; 136: 410-41 I.
  • Heimbach DM, Engrav LH, Marvin JA, et al. Toxic epidermal necrolysis: a step forward in treatment. JAMA 1987;257:2171-2175.
  • Murphy JT, Purdue GF, Hunt JL. Toxic epidermal necrolysis. J Burn Care Rehabil 1997; 18: 417-420.
  • McGee T, Munster A. Toxic epidermal necrolysis syndrome: mortality rate reduced with early referral to regional burn center. Plast Reconstr Surg 1998; 102: 1018-1022.
  • Rasmussen JE. Erythema multiforme: should anyone care about the standards of care? Arch Dermatol 1995; 131: 726-728.
  • Roujeau J, Chosidow O, Saiag P, Guillaume J. Toxic epidermal necrolysis (Lyell syndrome). J Am Acad Dermatol 1990; 6: 1039-1053.
  • Bastuji-Garin S, Zahedi M, Guillaume JC, et al. Toxic epidermal necrolysis (Lyell syndrome) in 77 elderly patients. Age Ageing 1993; 22: 450-456.

Year 2002, Volume: 15 Issue: 3, 189 - 193, 03.12.2016

Cengiz Açıkel Ersin Ülkür Bahattin Çeliköz

Abstract

References

  • /. Bastuji-Garin S, Rzany li. Stem RS, Shear rill, Roujeau JC. A clinical classification of cases of toxic epidermal necrolysis, Stevens- Johnson syndrome, and erythema multiforme. Arch Dermatol 1993; 129: 92-96.
  • Wolkenstein PE, Roujeau JC, Revuz J. Drug- induced toxic epidermal necrolysis. Clin Dermatol 1998; 16: 399-409.
  • Weiglitman W. Toxic epidermal necrolysis. Review. Australas J Dermatol 1996; 37: 167- I 75.
  • Roujeau JC, Kelly J, Haldi L, et at. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. H Engl J Med 1995:333: 1600-1607.
  • Saiag P, Caumes E, Chosidow O, Revuz J, Roujeau JC. Drug-Induced toxic epidermal necrolysis (Lyell syndrome) in patients infected with the human immunodeficiency virus. J Am Acad Dermatol 1992; 26: 567- 574.
  • Tham TCK, Allen G, Hayes D, McGrady li, Riddell JG. Possible association between toxic epidermal necrolysis and ciprofloxacin. Lancet 1991; 338: 522.
  • Sakellariou G, Koukoudis P, Karpouzas J, et al. Plasma exchange treatment in drug- induced toxic epidermal necrolysis. Int J Artif Organs 1991; 14: 634-638.
  • Moshfeghi M, Mandler HD. Ciprofloxacin- induced toxic epidermal necrolysis. Ann Pharmacother 1993; 27: 1467-1469.
  • Yerasi AH, Oertel MD. Ciprofloxacin-induced toxic epidermal necrolysis. Ann Pharmacother 1996; 30: 297.
  • Livasy CA, Kaplan AM. Ciprofloxacin-induced toxic epidermal necrolysis: a case report. Dermatology 1997; 195: 173-175.
  • Uppal R, Jhaj R, Malhotra S. Adverse drug reactions to fluoroquinolones at a tertiary care hospital in northern India. J /tssoc Physicians India 1998; 46: 946-947.
  • Matsuno K, Kunihiro E, Yamatoya O, et al. Surveillance of adverse reactions due to ciprofloxacin in Japan. Drugs / 995; 49 Suppl 2: 495-496.
  • Grover JK. Unwanted effects of ciprofloxacin in Indian population. Ind J Physiol Pharmacol 1993; 37: 232-234.
  • Matthews MR, Caruso DM, Phillips BJ, Csontos LG. Culminant toxic epidermal necrolysis induced by trovafloxacin. Arch Intern Med 1999; 159: 2225.
  • Roujeau JC, Albengres E, Moritz S, et al. Lymphocyte transformation test in drug- induced toxic epidermal necrolysis. Int Arch Allergy Appl Immunol 1985; 78: 22-24.
  • Wolkenstein P, Chosidow O, Flechet ML, et al. Patch testing in severe cutaneous adverse drug reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Contact Dermatitis 1996; 35: 234-236.
  • I 7. Guillaume JC, Roujeau JC, Revuz J, Penso D, Touraine R. The culpit drugs in 87 cases of toxic epidermal necrolysis (Lyell's syndrome). Arch Dermatol 1987; 123: 1166-1 170.
  • Garcia-Doval I, LeCleach L, Bocquet H, Otero XL, Roujeau JC. Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death? Arch Dermatol 2000; 136: 323- 327.
  • Becker DS. Toxic epidermal necrolysis. Lancet 1998; 351: 1417-1420.
  • Stern RS. Improving the outcome of patients with toxic epidermal necrolysis and Stevens- Johnson syndrome. Arch Dermatol 2000; 136: 410-41 I.
  • Heimbach DM, Engrav LH, Marvin JA, et al. Toxic epidermal necrolysis: a step forward in treatment. JAMA 1987;257:2171-2175.
  • Murphy JT, Purdue GF, Hunt JL. Toxic epidermal necrolysis. J Burn Care Rehabil 1997; 18: 417-420.
  • McGee T, Munster A. Toxic epidermal necrolysis syndrome: mortality rate reduced with early referral to regional burn center. Plast Reconstr Surg 1998; 102: 1018-1022.
  • Rasmussen JE. Erythema multiforme: should anyone care about the standards of care? Arch Dermatol 1995; 131: 726-728.
  • Roujeau J, Chosidow O, Saiag P, Guillaume J. Toxic epidermal necrolysis (Lyell syndrome). J Am Acad Dermatol 1990; 6: 1039-1053.
  • Bastuji-Garin S, Zahedi M, Guillaume JC, et al. Toxic epidermal necrolysis (Lyell syndrome) in 77 elderly patients. Age Ageing 1993; 22: 450-456.
There are 26 citations in total.

Details

Journal Section Case Reports
Authors

Cengiz Açıkel This is me

Ersin Ülkür This is me

Bahattin Çeliköz This is me

Publication Date December 3, 2016
Published in Issue Year 2002 Volume: 15 Issue: 3

Cite

APA Açıkel, C., Ülkür, E., & Çeliköz, B. (2016). FATAL CIPROFLOXACIN-INDUCED TOXIC EPIDERMAL NECROLYSIS (LYELL SYNDROME): A CASE REPORT AND REVIEW OF THE LITERATURE. Marmara Medical Journal, 15(3), 189-193.
AMA Açıkel C, Ülkür E, Çeliköz B. FATAL CIPROFLOXACIN-INDUCED TOXIC EPIDERMAL NECROLYSIS (LYELL SYNDROME): A CASE REPORT AND REVIEW OF THE LITERATURE. Marmara Med J. March 2016;15(3):189-193.
Chicago Açıkel, Cengiz, Ersin Ülkür, and Bahattin Çeliköz. “FATAL CIPROFLOXACIN-INDUCED TOXIC EPIDERMAL NECROLYSIS (LYELL SYNDROME): A CASE REPORT AND REVIEW OF THE LITERATURE”. Marmara Medical Journal 15, no. 3 (March 2016): 189-93.
EndNote Açıkel C, Ülkür E, Çeliköz B (March 1, 2016) FATAL CIPROFLOXACIN-INDUCED TOXIC EPIDERMAL NECROLYSIS (LYELL SYNDROME): A CASE REPORT AND REVIEW OF THE LITERATURE. Marmara Medical Journal 15 3 189–193.
IEEE C. Açıkel, E. Ülkür, and B. Çeliköz, “FATAL CIPROFLOXACIN-INDUCED TOXIC EPIDERMAL NECROLYSIS (LYELL SYNDROME): A CASE REPORT AND REVIEW OF THE LITERATURE”, Marmara Med J, vol. 15, no. 3, pp. 189–193, 2016.
ISNAD Açıkel, Cengiz et al. “FATAL CIPROFLOXACIN-INDUCED TOXIC EPIDERMAL NECROLYSIS (LYELL SYNDROME): A CASE REPORT AND REVIEW OF THE LITERATURE”. Marmara Medical Journal 15/3 (March 2016), 189-193.
JAMA Açıkel C, Ülkür E, Çeliköz B. FATAL CIPROFLOXACIN-INDUCED TOXIC EPIDERMAL NECROLYSIS (LYELL SYNDROME): A CASE REPORT AND REVIEW OF THE LITERATURE. Marmara Med J. 2016;15:189–193.
MLA Açıkel, Cengiz et al. “FATAL CIPROFLOXACIN-INDUCED TOXIC EPIDERMAL NECROLYSIS (LYELL SYNDROME): A CASE REPORT AND REVIEW OF THE LITERATURE”. Marmara Medical Journal, vol. 15, no. 3, 2016, pp. 189-93.
Vancouver Açıkel C, Ülkür E, Çeliköz B. FATAL CIPROFLOXACIN-INDUCED TOXIC EPIDERMAL NECROLYSIS (LYELL SYNDROME): A CASE REPORT AND REVIEW OF THE LITERATURE. Marmara Med J. 2016;15(3):189-93.