Research Article
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Year 2002, Volume: 15 Issue: 1, 15 - 22, 03.12.2016

Abstract

References

  • Liu SX, Zhou M, Chen Y, Wen WY, Sun MJ. Lipoperoxidative injury to macrophages by oxidatively modified low density lipoprotein may play an important role in foam cell formation. Atherosclerosis 1996; 121:55- 61.
  • Morel DW. Altered LDL and HDL function induced by Lipid Peroxidation. In: Weber PC, Leaf A, eds. Atherosclerosis Reviews. Atherosclerosis Cellular Interactions, Growth Factors, and Lipids. Hew York: Raven Press, 1993:259-265.
  • Hasr A, Breckwoldt M. Estrogen replacement therapy' and cardiovascular protection: lipid mechanisms are the tip of an iceberg. Gynelcol Endocrinol 1998; 12: 43-59.
  • Luoma PV. Gene activation, apolipoprotein Al/high density lipoprotein, atherosclerosis prevention and longevity. Pharmacol Toxicol 1997; 81; 57-64.
  • Jacquish CE, Mahaney MC, Blangero J, Haffner SM, Stern MP, Mac Cluer JW. Genetic correlations between lipoprotein phenotypes and indicators of sex hormone levels in Mexican Americans. Atherosclerosis 1996; 122: I I 7-125.
  • Heller DA, de Faire U, Pedersen HL, Dahlen G, McClearn GE. Genetic and environmental influences on scrum lipid levels in twins. H Eng J Med 1993; 328: 1150-1156.
  • ¡scan A, Yigitoglu MR, Vurgun H, Uyanik BS, Akyildiz M. Low levels of high density cholesterol in Turkish children: an important risk factor. Acta Paediatr Jpn 1998; 40: 41-
  • Hergenc G, Schulte H, Assmann G, von Eckardstein A. Associations of obesity markers, insulin, and sex hormones with IIDL- cholesterol levels in Turkish and German individuals. Atherosclerosis 1999; 145; 147- 156
  • Koycu B, Kara T, (jamhdag O, Aydinh R, Verschuren WM, van Montfrans GA. Risk factors for cardiovascular diseases in Turks in Amsterdam and in Ankara. Hed Tijdschr Geneeskd 1997; 141: 882-888.
  • Yataco AR, Busby-Whitehead J, Drinkwater DT, Katzel LI. Relationship of body composition and cardiovascular fitness to lipoprotein lipid profiles in master athletes and sedentary men. Aging(Milano) 1997; 9 : 88-94.
  • Tikkanen HO, Hamalainen E, Sarna S, Adlercreutz H, Harkonen M. Associations between skeletal muscle properties, physical fitness, physical activity and coronary heart disease factors in men. Atherosclerosis 1998; 137: 377-89.
  • Patsch W, Sharett AR, Sorlie PD, Davis CE, Brown 5A. The relation of high density lipoprotein cholesterol and its subfractions to apolipoprotein Al and fasting triglycerides: the role of environmental factors. The Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 1992; 136: 546-557.
  • Shern-Brewer R, Santanam H, Wetzstein C, White-Welkley J, Partasarathy S. Exercise and cardiovascular disease: a new perspective. Arterioscler Thromb Vas Biol 1998; 18: 1181- 1187.
  • E x e r c i s e , H D L - c a n d o x i d a n t - a n t i o x i d a n l s
  • Kan ter M. Free radicals, exercise . and antioxidant supplementation. Froc riutr Soc 1998; 57: 9-13.
  • Tamatsu Y, Ryoya li, Toshia S, Malika M. Lipid peroxidation in maternal cord blood and protective mechanisms against activated oxygen toxicity in the blood. Am J Obstet Gynecol 1979; 135: 372-376.
  • Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase Clin Chem 1988; 34:497-500.
  • Jacobson B, Quiley LG, Lockitch G.
  • Adaptation of glutathione peroxidase assay to the Technichon RA-IOOO. Clin Chem 1988; 34: 2164-2165.
  • Medina-Navarro R, Lifshitz A, Wacher 3, flicks
  • JJ. Changes in human serum antioxidant capacity and peroxidation capacity and
  • peroxidation after four months of exposure to air pollutants. Arch Med Res 1997; 28: 205- 208.
  • Ortenblad N, Madsen R, Djurhuus MS.
  • Antioxidant status and lipid peroxidation after short-term maximal exercise in trained and untrained humans. Am J Physiol 1997; 272 :l< 1258-1263.
  • Pereira B, Costa Rosa LP, Safi DA, Medeiros
  • MI1, Curi R, Bechara EJ. Superoxide
  • dismutase, catalase, and glutathione peroxidase activities in muscle and lymphoid organs of sedentary and exercise-trained rats. Physiol Behav 1994/56:1095-1099.
  • Gutteridge JMC, Plalliwell B. Antioxidants in nutrition, health, and disease. Hew York: Oxford Press, 1994:40-63.
  • riielsen JB, Nielsen F, Grandjean P. Antioxidantive enzyme activities in human erythrocytes. Clin Chem 1997; 43: 562-568.
  • Plalliwell B, Gutteridge JMC. Lipid peroxidation-.a radical chain reaction. In: Free Radicals in Biology and Medicine. Oxford: Clarendon Press, 1991: 188-277.
  • Liu Z, Wildhirt SM, Weismuller S, Schulze C, Conrad N, Reicart B. Nitric oxide and endothelin in the development of cardiac allograft vasculopathy. Potential targets for therapeutic interventions. Atherosclerosis 1998; 140: 1-14.
  • Lynch SM, Frei B, Morrow JD, et al. Vascular superoxide dismutase deficiency impairs endothelial vasodilator function through direct inactivation of nitric oxide and increased lipid peroxidation. Arterioscler Thromb Vase Biol 1997: 17; 2975-2981.
  • Tribble DL, Gong EL, Leeuwenburgh C, et a!. Fatty streak formation in fat-fed mice expressing human copper-zinc superoxide dismutase. Arterioscler Thromb Vase Biol 1997; 17:1734-1740.
  • XiXR, Qureshi I A, Wu XD, Khan I LI, Huang YB, Shiarkar E. The effect of exercise training on physical fitness and plasma lipids in young Chinese men and women. Zhonghua Yi Xue Za Zhi 1997/59 : 341-347.
  • Thune L Njolstad I, Lochnen ML, Forde OH. Physical activity improves the metabolic risk profiles in men and women: the Tromso Study. Arch Intern Med 1998 ;158: 1633- 1640.
  • Marzatico F, Pansarasa O, Bertorelli L, Somenzini L, Della Valle G. Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidémie performances in highly trained aerobic and sprint athletes. J Sports Med Phys Fitness 1997; 37: 235-239.
  • Jenkins RR, Goldfarb A. Introduction: oxidant stress, aging, and exercise. Med Sei Sports Exerc 1993; 25:210-212.
  • Mena P, Mayner M, Guttierrez JM, Mayner J, Timon J, Campillo JE. Erythrocyte free radical scavenging enzymes in bicycle professional racers: Adaptation to stress. Int J Sports Med 1991; 12: 563-566.
  • Criswell D, Powers S, Dodd S, et al. High intensity training induced changes in skeletal muscle antioxidant enzyme activities. Med Sei Sports Exerc 1993; 25: 1135-1 140.
  • Powers SK, Criswell D, Lawlel J, et al. Rigorous exercise training increases superoxide dismutase activity in ventricular myocardium. Am J Physiol 1993; 265(6 Pt2) : H2094-2098.
  • Tiidus PM, Pushkarenko J, Houston ME. Lack of antioxidant adaptation to short term aerobic training in human muscle. Am J Physiol 1996; 27: R 832-836
  • Ohno H, Yamashita H, Ookawara T, Saitoh D, Mitnura R, Taniguchi N. Effects of brief exercise on the concentrations of immunoreactive superoxide dismutase isoenzymes in human plasma. Tohoku J Exp Med 1992; 167: 301-303
  • Kuller LH. The relationship between serum albumin levels and risk of coronary heart disease in multiple factor intervention trial. Am J Epidemiol 1971; 134: 1266-1277.
  • Zmuda JM, Yurgalevitch SM, Flynn MM, et al. Exercise training has little effect on HDL levels
  • T ü l i n Ö z s ü l l ü , e t a l
  • and metabolism in men with initially low HDL cholesterol. Atherosclerosis 137; I: 215-221.
  • Stefanick ML, Mackey S, Sheehan M, Ellsworth hi, Haskell WL, Wood PD. Effects of diet and exercise in men and postmenopausal women with low levels of HDL-cholesterol and high levels of LDL-cholesterol. FI Eng J Med 1998; 339:12-20.
  • Miller TD, Balady QJ, Fletcher GF. Exercise and its role in the prevention and
  • rehabilitation of cardiovascular disease. Ann Behav Med 1997; 19: 220-229.
  • Ferguson MA, Alderson ML, Trost SG, Essig DA, Burke JR, Durstine JL. Effects of four different single exercise sessions on lipids, lipoproteins, and lipoprotein lipase. Appl Physiol 1998; 85: I 169-1174.
  • Wood D. European and American recommendations for coronary heart disease prevention. Eur Heart J 1998 ; 19 Suppl A : A 1-12.

DOES EXERCISE HAVE FAVORABLE EFFECTS ON BLOOD LIPIDS, HDL-CHOLESTEROL, OXIDANT-ANTIOXIDANT STATUS AND CORONARY HEART DISEASE RISK FACTORS IN YOUNG TURKISH MEN?

Year 2002, Volume: 15 Issue: 1, 15 - 22, 03.12.2016

Abstract

Objective: Our aim was to determine the effects of exercise on blood lipids especially on HDL- cholesterol and the oxidant-antioxidant status and associations between blood lipids, and the oxidant-antioxidant status.
Methods: Blood lipids, antioxidant enzymes like erythrocyte GpX and SOD, plasma TBARS as an indicator of lipid peroxidation, total antioxidant status, antioxidant molecules like albumin, uric acid, and biluribin were measured in healthy young sedentary and exercising men. Our study group was composed of volunteers from the navy ; 34 were sedentary (Group A) while 44 exercised 7-14 hours (Group Bl) and 35 exercised 42 hours (Group Bl I) weekly.
Results: Mean (standard deviation) of HDL- Cholesterol in Groups A, Bl, and Bll were 35.7(7.3), 36.7(9.6), and 35.3( 9.7) mg/dl respectively. Similarly mean (standard deviations) for antioxidant/oxidant status were found as follows: GpX :17.4(7.9), 22.2(7.6), and 29.1(7.6); SOD: 2249.6(1263), 1835(689), and 1594(510) U/ gHb ; for total antioxidant status (TAS): 1.8(0.46), 2.0(0.9), and 1.9(0.4)mmol/L; TBARS: 0.48(0.16), 0.83(0.57), and 0.63(0.08) nmol/L.
Conclusion: No favorable effects of exercise on blood lipids were detected, however the effect of
exercise on fibrinogen was beneficial . SOD decreased and GpX increased significantly with exercise. There was no significant difference in TAS among the sedentary and exercising groups.

References

  • Liu SX, Zhou M, Chen Y, Wen WY, Sun MJ. Lipoperoxidative injury to macrophages by oxidatively modified low density lipoprotein may play an important role in foam cell formation. Atherosclerosis 1996; 121:55- 61.
  • Morel DW. Altered LDL and HDL function induced by Lipid Peroxidation. In: Weber PC, Leaf A, eds. Atherosclerosis Reviews. Atherosclerosis Cellular Interactions, Growth Factors, and Lipids. Hew York: Raven Press, 1993:259-265.
  • Hasr A, Breckwoldt M. Estrogen replacement therapy' and cardiovascular protection: lipid mechanisms are the tip of an iceberg. Gynelcol Endocrinol 1998; 12: 43-59.
  • Luoma PV. Gene activation, apolipoprotein Al/high density lipoprotein, atherosclerosis prevention and longevity. Pharmacol Toxicol 1997; 81; 57-64.
  • Jacquish CE, Mahaney MC, Blangero J, Haffner SM, Stern MP, Mac Cluer JW. Genetic correlations between lipoprotein phenotypes and indicators of sex hormone levels in Mexican Americans. Atherosclerosis 1996; 122: I I 7-125.
  • Heller DA, de Faire U, Pedersen HL, Dahlen G, McClearn GE. Genetic and environmental influences on scrum lipid levels in twins. H Eng J Med 1993; 328: 1150-1156.
  • ¡scan A, Yigitoglu MR, Vurgun H, Uyanik BS, Akyildiz M. Low levels of high density cholesterol in Turkish children: an important risk factor. Acta Paediatr Jpn 1998; 40: 41-
  • Hergenc G, Schulte H, Assmann G, von Eckardstein A. Associations of obesity markers, insulin, and sex hormones with IIDL- cholesterol levels in Turkish and German individuals. Atherosclerosis 1999; 145; 147- 156
  • Koycu B, Kara T, (jamhdag O, Aydinh R, Verschuren WM, van Montfrans GA. Risk factors for cardiovascular diseases in Turks in Amsterdam and in Ankara. Hed Tijdschr Geneeskd 1997; 141: 882-888.
  • Yataco AR, Busby-Whitehead J, Drinkwater DT, Katzel LI. Relationship of body composition and cardiovascular fitness to lipoprotein lipid profiles in master athletes and sedentary men. Aging(Milano) 1997; 9 : 88-94.
  • Tikkanen HO, Hamalainen E, Sarna S, Adlercreutz H, Harkonen M. Associations between skeletal muscle properties, physical fitness, physical activity and coronary heart disease factors in men. Atherosclerosis 1998; 137: 377-89.
  • Patsch W, Sharett AR, Sorlie PD, Davis CE, Brown 5A. The relation of high density lipoprotein cholesterol and its subfractions to apolipoprotein Al and fasting triglycerides: the role of environmental factors. The Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 1992; 136: 546-557.
  • Shern-Brewer R, Santanam H, Wetzstein C, White-Welkley J, Partasarathy S. Exercise and cardiovascular disease: a new perspective. Arterioscler Thromb Vas Biol 1998; 18: 1181- 1187.
  • E x e r c i s e , H D L - c a n d o x i d a n t - a n t i o x i d a n l s
  • Kan ter M. Free radicals, exercise . and antioxidant supplementation. Froc riutr Soc 1998; 57: 9-13.
  • Tamatsu Y, Ryoya li, Toshia S, Malika M. Lipid peroxidation in maternal cord blood and protective mechanisms against activated oxygen toxicity in the blood. Am J Obstet Gynecol 1979; 135: 372-376.
  • Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase Clin Chem 1988; 34:497-500.
  • Jacobson B, Quiley LG, Lockitch G.
  • Adaptation of glutathione peroxidase assay to the Technichon RA-IOOO. Clin Chem 1988; 34: 2164-2165.
  • Medina-Navarro R, Lifshitz A, Wacher 3, flicks
  • JJ. Changes in human serum antioxidant capacity and peroxidation capacity and
  • peroxidation after four months of exposure to air pollutants. Arch Med Res 1997; 28: 205- 208.
  • Ortenblad N, Madsen R, Djurhuus MS.
  • Antioxidant status and lipid peroxidation after short-term maximal exercise in trained and untrained humans. Am J Physiol 1997; 272 :l< 1258-1263.
  • Pereira B, Costa Rosa LP, Safi DA, Medeiros
  • MI1, Curi R, Bechara EJ. Superoxide
  • dismutase, catalase, and glutathione peroxidase activities in muscle and lymphoid organs of sedentary and exercise-trained rats. Physiol Behav 1994/56:1095-1099.
  • Gutteridge JMC, Plalliwell B. Antioxidants in nutrition, health, and disease. Hew York: Oxford Press, 1994:40-63.
  • riielsen JB, Nielsen F, Grandjean P. Antioxidantive enzyme activities in human erythrocytes. Clin Chem 1997; 43: 562-568.
  • Plalliwell B, Gutteridge JMC. Lipid peroxidation-.a radical chain reaction. In: Free Radicals in Biology and Medicine. Oxford: Clarendon Press, 1991: 188-277.
  • Liu Z, Wildhirt SM, Weismuller S, Schulze C, Conrad N, Reicart B. Nitric oxide and endothelin in the development of cardiac allograft vasculopathy. Potential targets for therapeutic interventions. Atherosclerosis 1998; 140: 1-14.
  • Lynch SM, Frei B, Morrow JD, et al. Vascular superoxide dismutase deficiency impairs endothelial vasodilator function through direct inactivation of nitric oxide and increased lipid peroxidation. Arterioscler Thromb Vase Biol 1997: 17; 2975-2981.
  • Tribble DL, Gong EL, Leeuwenburgh C, et a!. Fatty streak formation in fat-fed mice expressing human copper-zinc superoxide dismutase. Arterioscler Thromb Vase Biol 1997; 17:1734-1740.
  • XiXR, Qureshi I A, Wu XD, Khan I LI, Huang YB, Shiarkar E. The effect of exercise training on physical fitness and plasma lipids in young Chinese men and women. Zhonghua Yi Xue Za Zhi 1997/59 : 341-347.
  • Thune L Njolstad I, Lochnen ML, Forde OH. Physical activity improves the metabolic risk profiles in men and women: the Tromso Study. Arch Intern Med 1998 ;158: 1633- 1640.
  • Marzatico F, Pansarasa O, Bertorelli L, Somenzini L, Della Valle G. Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidémie performances in highly trained aerobic and sprint athletes. J Sports Med Phys Fitness 1997; 37: 235-239.
  • Jenkins RR, Goldfarb A. Introduction: oxidant stress, aging, and exercise. Med Sei Sports Exerc 1993; 25:210-212.
  • Mena P, Mayner M, Guttierrez JM, Mayner J, Timon J, Campillo JE. Erythrocyte free radical scavenging enzymes in bicycle professional racers: Adaptation to stress. Int J Sports Med 1991; 12: 563-566.
  • Criswell D, Powers S, Dodd S, et al. High intensity training induced changes in skeletal muscle antioxidant enzyme activities. Med Sei Sports Exerc 1993; 25: 1135-1 140.
  • Powers SK, Criswell D, Lawlel J, et al. Rigorous exercise training increases superoxide dismutase activity in ventricular myocardium. Am J Physiol 1993; 265(6 Pt2) : H2094-2098.
  • Tiidus PM, Pushkarenko J, Houston ME. Lack of antioxidant adaptation to short term aerobic training in human muscle. Am J Physiol 1996; 27: R 832-836
  • Ohno H, Yamashita H, Ookawara T, Saitoh D, Mitnura R, Taniguchi N. Effects of brief exercise on the concentrations of immunoreactive superoxide dismutase isoenzymes in human plasma. Tohoku J Exp Med 1992; 167: 301-303
  • Kuller LH. The relationship between serum albumin levels and risk of coronary heart disease in multiple factor intervention trial. Am J Epidemiol 1971; 134: 1266-1277.
  • Zmuda JM, Yurgalevitch SM, Flynn MM, et al. Exercise training has little effect on HDL levels
  • T ü l i n Ö z s ü l l ü , e t a l
  • and metabolism in men with initially low HDL cholesterol. Atherosclerosis 137; I: 215-221.
  • Stefanick ML, Mackey S, Sheehan M, Ellsworth hi, Haskell WL, Wood PD. Effects of diet and exercise in men and postmenopausal women with low levels of HDL-cholesterol and high levels of LDL-cholesterol. FI Eng J Med 1998; 339:12-20.
  • Miller TD, Balady QJ, Fletcher GF. Exercise and its role in the prevention and
  • rehabilitation of cardiovascular disease. Ann Behav Med 1997; 19: 220-229.
  • Ferguson MA, Alderson ML, Trost SG, Essig DA, Burke JR, Durstine JL. Effects of four different single exercise sessions on lipids, lipoproteins, and lipoprotein lipase. Appl Physiol 1998; 85: I 169-1174.
  • Wood D. European and American recommendations for coronary heart disease prevention. Eur Heart J 1998 ; 19 Suppl A : A 1-12.
There are 51 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Research
Authors

Tülin Özsüllü This is me

Gülay Hergenç This is me

Publication Date December 3, 2016
Published in Issue Year 2002 Volume: 15 Issue: 1

Cite

APA Özsüllü, T., & Hergenç, G. (2016). DOES EXERCISE HAVE FAVORABLE EFFECTS ON BLOOD LIPIDS, HDL-CHOLESTEROL, OXIDANT-ANTIOXIDANT STATUS AND CORONARY HEART DISEASE RISK FACTORS IN YOUNG TURKISH MEN?. Marmara Medical Journal, 15(1), 15-22.
AMA Özsüllü T, Hergenç G. DOES EXERCISE HAVE FAVORABLE EFFECTS ON BLOOD LIPIDS, HDL-CHOLESTEROL, OXIDANT-ANTIOXIDANT STATUS AND CORONARY HEART DISEASE RISK FACTORS IN YOUNG TURKISH MEN?. Marmara Med J. March 2016;15(1):15-22.
Chicago Özsüllü, Tülin, and Gülay Hergenç. “DOES EXERCISE HAVE FAVORABLE EFFECTS ON BLOOD LIPIDS, HDL-CHOLESTEROL, OXIDANT-ANTIOXIDANT STATUS AND CORONARY HEART DISEASE RISK FACTORS IN YOUNG TURKISH MEN?”. Marmara Medical Journal 15, no. 1 (March 2016): 15-22.
EndNote Özsüllü T, Hergenç G (March 1, 2016) DOES EXERCISE HAVE FAVORABLE EFFECTS ON BLOOD LIPIDS, HDL-CHOLESTEROL, OXIDANT-ANTIOXIDANT STATUS AND CORONARY HEART DISEASE RISK FACTORS IN YOUNG TURKISH MEN?. Marmara Medical Journal 15 1 15–22.
IEEE T. Özsüllü and G. Hergenç, “DOES EXERCISE HAVE FAVORABLE EFFECTS ON BLOOD LIPIDS, HDL-CHOLESTEROL, OXIDANT-ANTIOXIDANT STATUS AND CORONARY HEART DISEASE RISK FACTORS IN YOUNG TURKISH MEN?”, Marmara Med J, vol. 15, no. 1, pp. 15–22, 2016.
ISNAD Özsüllü, Tülin - Hergenç, Gülay. “DOES EXERCISE HAVE FAVORABLE EFFECTS ON BLOOD LIPIDS, HDL-CHOLESTEROL, OXIDANT-ANTIOXIDANT STATUS AND CORONARY HEART DISEASE RISK FACTORS IN YOUNG TURKISH MEN?”. Marmara Medical Journal 15/1 (March 2016), 15-22.
JAMA Özsüllü T, Hergenç G. DOES EXERCISE HAVE FAVORABLE EFFECTS ON BLOOD LIPIDS, HDL-CHOLESTEROL, OXIDANT-ANTIOXIDANT STATUS AND CORONARY HEART DISEASE RISK FACTORS IN YOUNG TURKISH MEN?. Marmara Med J. 2016;15:15–22.
MLA Özsüllü, Tülin and Gülay Hergenç. “DOES EXERCISE HAVE FAVORABLE EFFECTS ON BLOOD LIPIDS, HDL-CHOLESTEROL, OXIDANT-ANTIOXIDANT STATUS AND CORONARY HEART DISEASE RISK FACTORS IN YOUNG TURKISH MEN?”. Marmara Medical Journal, vol. 15, no. 1, 2016, pp. 15-22.
Vancouver Özsüllü T, Hergenç G. DOES EXERCISE HAVE FAVORABLE EFFECTS ON BLOOD LIPIDS, HDL-CHOLESTEROL, OXIDANT-ANTIOXIDANT STATUS AND CORONARY HEART DISEASE RISK FACTORS IN YOUNG TURKISH MEN?. Marmara Med J. 2016;15(1):15-22.