APROTININ IMPROVES Ca2+ - Mg2+ / ATPase LEVELS İN ISCHEMIA-REPERFUSION INJURY1'2

Year 2002, Volume: 15 Issue: 1, 23 - 26, 03.12.2016

Selim Isbir Rıza Doğan Metin Demircin İlhan Paşaoğlu

Abstract

Objective: The aim of this study is to determine the effect of aprotinin, on calcium activated and magnesium dependent adenosine 5’ triphosphatase (Ca2+-Mg2+/ATP ase) levels.
Methods: Twenty patients who had elective coronary artery bypass grafting (CABG) were randomly divided into two groups (n= 10, in each). Group A patients received full dose aprotinin (20 000 lU/kg as pretreatment followed by 7500 lU/kg for 6 hours) and Group B patients received normal saline as control group. Erythrocyte membrane Ca2+-Mg2+/ATP ase levels were measured.
Results: Ca2*-Mg2+ /ATPase levels were protected in aprotinin group, 807.60+32.62 vs 634.28+22.91 (p<0.05) at post-operative 24th hour. (p<0.05).
Conclusion: Aprotinin protected the erythocyte membrane Ca2<-Mg2+ ATP/ase from oxidant stress thus it might affect the cell membrane stabilization.
Key Words: Aprotinin, Ischemia-Reperfusion injury, Ca2t-Mg2+/ATPase.

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