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Year 2003, Volume: 16 Issue: 1, 7 - 11, 03.12.2016

Abstract

References

  • Catania A, Lipton JM. Alpha-melanocyte stimulating hormone in the modulation of host reactions. Endocr Rev 1993; 14: 54-57.
  • Catania A, Rajora hi, Capsoni, F, Minonzio F, Star RA, Lipton JM. The neuropeptide a-MSH has specific receptors on neutrophils and reduces chemotaxis in vivo. Peptides 1996; 17: 675-679.
  • Mason MJ, Van Epps D. Modulation of IL-1, tumor necrosis factor, and C5a-mediated murine neutrophil migration by alpha- melanocyte stimulating hormone. J Immunol 1989; 142: 1646-1651.
  • Perretti M, Appleton I, Parente L, Flower RJ. Pharmacology of interleukin-1 -induced neutrophil migration. Agents Actions 1993; 38: C64-65.
  • Rajora Fi, Ceriani G, Catania A, Star RA, Murphy MT, Upton JM. a-MSH production, receptors, and influence on neopterin, in a human monocyte/macrophage cell Une. J Leukocyte Biol 1996; 59: 248-253.
  • Star RA, Rajora Id, Huang J, Stock RC, Catania A, Lipton JM. Evidence of autocrine modulation of macrophage nitric oxide synthase by a-MSH. Proc HatI Acad Sci USA 1995; 92: 8016-8020.
  • Jones II WG, Minei JP, Barber AE, Fahey III TJ, Shires III GT, Shires GT. Splancnic vasoconstriction and bacterial translocation after thermal trauma. Am J Physiol 1991 ; 261 : HI 190-H1 196.
  • Morris SE, Havaratnam H, Townsend CM, Herndon DH. A comparison of the effect of thermal injury and smoke inhalation on bacterial translocation. J Trauma 1990; 30: 639-643.
  • Youn YR, LaLonde C, Demling R. The role of mediators in the response to thermal injury. World J Surg 1992; 16: 30-36.
  • Chen LW, Hsu CM, Cha MC, Chen JS, Chen SC. Changes in gut mucosal nitric oxide synthase (HOS) activity after thermal injury and its relation with barrier failure. Shock 1999; I I: 104-1 10.
  • Chen LW, Hsu CM, Wang JS, Chen JS, Chen SC. Specific inhibition of ¡HOS decreases the intestinal mucosal peroxynitrite level and improves the barrier function after thermal injury. Burns 1998; 24: 699-705.
  • Rrawisz JE, Sharon P, Stenson W F. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Gastroenterology 1984; 87: 1344- 1350.
  • Haklar G, Özveri ES, Yüksel M, Aktan AÖ, Yalçın /IS. Different kinds of reactive oxygen and nitrogen species were detected in colon and breast tumors. Cancer Letters 2001; 165: 219-224.
  • Davies GR, Simmonds HJ, Stevens TR, et at. Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 1994:35: 179-185.
  • Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993; 91: 2546-2551.
  • Clancy RM, Leszczynska-Piziak J, Abramson SB. Hitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide production via a direct action on the HADPH oxidase. J Clin Invest 1992; 90: 1116-1121.

THE EFFECT OF α-MELANOCYTE STIMULATING HORMONE ON BURN-INDUCED OXIDANT PRODUCTION BY RAT PERITONEAL NEUTROPHILS

Year 2003, Volume: 16 Issue: 1, 7 - 11, 03.12.2016

Abstract

Objective: Previous findings related to the anti-inflammatory effects of α-melanocyte stimulating hormone (α-MSH) indicate that the peptide might inhibit inflammation by antagonizing the effects of local cytokines or by inhibiting neutrophil functions. In addition, it is a potent inhibitor of the induction of the inducible nitric oxide synthase (iNOS) in cultured macrophages and of nitric oxide (NO) production in a sepsis model. This study was designed to investigate whether α-MSH affects reactive oxygen metabolite production by rat peritoneal neutrophils following burn injury and whether NO is involved in this effect.

Methods: The neutrophils were removed from the peritoneum of the rats 6 h after burn or sham trauma. Cells (2 X 106 /ml) were treated with the increasing concentrations of α-MSH (10–12 M, 10–10 M, 10–8 M or 10–6 M). Nitric oxide donor, sodium nitroprusside ranging from (10–10 - 10–4 M) was added to the cells in the presence of α-MSH. Reactive oxygen metabolite production was measured by chemiluminescence (CL) technique using luminol or lucigenin probes.

Results: Lucigenin CL value of cells obtained from burn animals was significantly higher than those obtained from the sham group. α-MSH caused significant reductions in high lucigenin CL values and this effect was partly inhibited by sodium nitroprusside.

Conclusion: Our results suggest that α-MSH is effective in preventing oxidant production by neutrophils activated by burn trauma, at least in part, by a mechanism involving nitric oxide. 

References

  • Catania A, Lipton JM. Alpha-melanocyte stimulating hormone in the modulation of host reactions. Endocr Rev 1993; 14: 54-57.
  • Catania A, Rajora hi, Capsoni, F, Minonzio F, Star RA, Lipton JM. The neuropeptide a-MSH has specific receptors on neutrophils and reduces chemotaxis in vivo. Peptides 1996; 17: 675-679.
  • Mason MJ, Van Epps D. Modulation of IL-1, tumor necrosis factor, and C5a-mediated murine neutrophil migration by alpha- melanocyte stimulating hormone. J Immunol 1989; 142: 1646-1651.
  • Perretti M, Appleton I, Parente L, Flower RJ. Pharmacology of interleukin-1 -induced neutrophil migration. Agents Actions 1993; 38: C64-65.
  • Rajora Fi, Ceriani G, Catania A, Star RA, Murphy MT, Upton JM. a-MSH production, receptors, and influence on neopterin, in a human monocyte/macrophage cell Une. J Leukocyte Biol 1996; 59: 248-253.
  • Star RA, Rajora Id, Huang J, Stock RC, Catania A, Lipton JM. Evidence of autocrine modulation of macrophage nitric oxide synthase by a-MSH. Proc HatI Acad Sci USA 1995; 92: 8016-8020.
  • Jones II WG, Minei JP, Barber AE, Fahey III TJ, Shires III GT, Shires GT. Splancnic vasoconstriction and bacterial translocation after thermal trauma. Am J Physiol 1991 ; 261 : HI 190-H1 196.
  • Morris SE, Havaratnam H, Townsend CM, Herndon DH. A comparison of the effect of thermal injury and smoke inhalation on bacterial translocation. J Trauma 1990; 30: 639-643.
  • Youn YR, LaLonde C, Demling R. The role of mediators in the response to thermal injury. World J Surg 1992; 16: 30-36.
  • Chen LW, Hsu CM, Cha MC, Chen JS, Chen SC. Changes in gut mucosal nitric oxide synthase (HOS) activity after thermal injury and its relation with barrier failure. Shock 1999; I I: 104-1 10.
  • Chen LW, Hsu CM, Wang JS, Chen JS, Chen SC. Specific inhibition of ¡HOS decreases the intestinal mucosal peroxynitrite level and improves the barrier function after thermal injury. Burns 1998; 24: 699-705.
  • Rrawisz JE, Sharon P, Stenson W F. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Gastroenterology 1984; 87: 1344- 1350.
  • Haklar G, Özveri ES, Yüksel M, Aktan AÖ, Yalçın /IS. Different kinds of reactive oxygen and nitrogen species were detected in colon and breast tumors. Cancer Letters 2001; 165: 219-224.
  • Davies GR, Simmonds HJ, Stevens TR, et at. Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 1994:35: 179-185.
  • Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993; 91: 2546-2551.
  • Clancy RM, Leszczynska-Piziak J, Abramson SB. Hitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide production via a direct action on the HADPH oxidase. J Clin Invest 1992; 90: 1116-1121.
There are 16 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Research
Authors

Berna Oktar This is me

Meral Yüksel This is me

İnci Alican

Publication Date December 3, 2016
Published in Issue Year 2003 Volume: 16 Issue: 1

Cite

APA Oktar, B., Yüksel, M., & Alican, İ. (2016). THE EFFECT OF α-MELANOCYTE STIMULATING HORMONE ON BURN-INDUCED OXIDANT PRODUCTION BY RAT PERITONEAL NEUTROPHILS. Marmara Medical Journal, 16(1), 7-11.
AMA Oktar B, Yüksel M, Alican İ. THE EFFECT OF α-MELANOCYTE STIMULATING HORMONE ON BURN-INDUCED OXIDANT PRODUCTION BY RAT PERITONEAL NEUTROPHILS. Marmara Med J. March 2016;16(1):7-11.
Chicago Oktar, Berna, Meral Yüksel, and İnci Alican. “THE EFFECT OF α-MELANOCYTE STIMULATING HORMONE ON BURN-INDUCED OXIDANT PRODUCTION BY RAT PERITONEAL NEUTROPHILS”. Marmara Medical Journal 16, no. 1 (March 2016): 7-11.
EndNote Oktar B, Yüksel M, Alican İ (March 1, 2016) THE EFFECT OF α-MELANOCYTE STIMULATING HORMONE ON BURN-INDUCED OXIDANT PRODUCTION BY RAT PERITONEAL NEUTROPHILS. Marmara Medical Journal 16 1 7–11.
IEEE B. Oktar, M. Yüksel, and İ. Alican, “THE EFFECT OF α-MELANOCYTE STIMULATING HORMONE ON BURN-INDUCED OXIDANT PRODUCTION BY RAT PERITONEAL NEUTROPHILS”, Marmara Med J, vol. 16, no. 1, pp. 7–11, 2016.
ISNAD Oktar, Berna et al. “THE EFFECT OF α-MELANOCYTE STIMULATING HORMONE ON BURN-INDUCED OXIDANT PRODUCTION BY RAT PERITONEAL NEUTROPHILS”. Marmara Medical Journal 16/1 (March 2016), 7-11.
JAMA Oktar B, Yüksel M, Alican İ. THE EFFECT OF α-MELANOCYTE STIMULATING HORMONE ON BURN-INDUCED OXIDANT PRODUCTION BY RAT PERITONEAL NEUTROPHILS. Marmara Med J. 2016;16:7–11.
MLA Oktar, Berna et al. “THE EFFECT OF α-MELANOCYTE STIMULATING HORMONE ON BURN-INDUCED OXIDANT PRODUCTION BY RAT PERITONEAL NEUTROPHILS”. Marmara Medical Journal, vol. 16, no. 1, 2016, pp. 7-11.
Vancouver Oktar B, Yüksel M, Alican İ. THE EFFECT OF α-MELANOCYTE STIMULATING HORMONE ON BURN-INDUCED OXIDANT PRODUCTION BY RAT PERITONEAL NEUTROPHILS. Marmara Med J. 2016;16(1):7-11.