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Asymptomatic persistent non-virus non-alcohol related elevation of aminotransferase levels: a rare case and review of the literature

Year 2016, Volume: 29 Issue: 3, 181 - 184, 15.10.2016

Abstract

Alanine aminotransferase (ALT) and aspartate aminotransferase

(AST) are found in the liver in their highest concentrations. Two

most common causes of asymptomatic transaminase elevation

are viral infections and alcohol intake. Persistent non-viral nonalcohol

related elevation of aminotransferases indicates that one

or both aminotransferase levels exceed the upper reference limit

for a period of at least 4 weeks. Causes are classified as hepatic;

such as steatosis, autoimmune hepatitis, Wilson’s disease,

hemachromatosis, and nonhepatic; such as celiac disease,

myopathy and hyperthyroidism. Drug use and substance abuse

may also cause an increase in aminotransferase levels. Here, we

report a fifty-eight-year old female patient who had asymptomatic

non-viral non-alcohol related aminotransferase elevation for a year

incidentally diagnosed with malignant infiltration of the liver. It

should be noted that, malignant infiltration of the liver may also be

a rare cause of asymptomatic persistent elevation of transaminases.

Such cases, especially with suspected malignancy should be

evaluated in terms of this condition.

References

  • Pratt DS, Kaplan MM. Evaluation of abnormal liverenzyme results in asymptomatic patients. N Engl J Med 2000;342:1266-1271.

Virüs ve alkol ilişkili olmayan asemptomatik, persistan aminotransferaz düzeylerinin yüksekliği: nadir bir vaka ve literatürün özeti

Year 2016, Volume: 29 Issue: 3, 181 - 184, 15.10.2016

Abstract

Alanin aminotransferaz (ALT) ve aspartat aminotransferaz (AST)

en yüksek konsantrasyonlarda karaciğerde bulunur. Asemptomatik

transaminaz yüksekliğinin en sık iki sebebi viral enfeksiyonlar

ve alkol kullanımıdır. Virüs ve alkol ilişkisi olmadan persistan

aminotransferans yüksekliği, transaminazların biri veya ikisinin

üst referans değerini en az 4 hafta aşması olarak tanımlanır.

Bu yüksekliğe, steatoz, otoimmün hepatit, Wilson hastalığı,

hemokromatoz gibi hepatik kaynaklı nedenler ve çölyak hastalığı,

miyopati ve hipertiroidizm gibi hepatik olmayan nedenler sebep

olabilir. İlaç kullanımı ve uyuşturucu madde kullanımı da

aminotransferaz yüksekliğine sebep olabilir. Bu vakada elli sekiz

yaşında kadın bir hasta sunmaktayız. Hastanın virus ve alkol ilişkisi

olmadan 1 yıl süren aminotransferaz yüksekliği mevcut olup hasta

insidental olarak malin karaciğer infiltrasyonu tanısı almıştır.

Karaciğerin malin infiltrasyonunun da persistan asemptomatik

transaminaz yüksekliğine sebep olabileceği unutulmamalıdır. Bu

tarz hastalarda, özellikle malignite şüphesi olan vakalar bu yönden

de değerlendirilmelidir.

References

  • Pratt DS, Kaplan MM. Evaluation of abnormal liverenzyme results in asymptomatic patients. N Engl J Med 2000;342:1266-1271.
There are 1 citations in total.

Details

Subjects Clinical Sciences
Journal Section Review Makaleler
Authors

Gokhan Tazegul This is me

Neslihan Gunes This is me

Mete Akın This is me

Gulsum Ozlem Elpek This is me

Adil Boz This is me

Publication Date October 15, 2016
Published in Issue Year 2016 Volume: 29 Issue: 3

Cite

APA Tazegul, G., Gunes, N., Akın, M., Elpek, G. O., et al. (2016). Asymptomatic persistent non-virus non-alcohol related elevation of aminotransferase levels: a rare case and review of the literature. Marmara Medical Journal, 29(3), 181-184. https://doi.org/10.5472/MMJcr.2903.02
AMA Tazegul G, Gunes N, Akın M, Elpek GO, Boz A. Asymptomatic persistent non-virus non-alcohol related elevation of aminotransferase levels: a rare case and review of the literature. Marmara Med J. October 2016;29(3):181-184. doi:10.5472/MMJcr.2903.02
Chicago Tazegul, Gokhan, Neslihan Gunes, Mete Akın, Gulsum Ozlem Elpek, and Adil Boz. “Asymptomatic Persistent Non-Virus Non-Alcohol Related Elevation of Aminotransferase Levels: A Rare Case and Review of the Literature”. Marmara Medical Journal 29, no. 3 (October 2016): 181-84. https://doi.org/10.5472/MMJcr.2903.02.
EndNote Tazegul G, Gunes N, Akın M, Elpek GO, Boz A (October 1, 2016) Asymptomatic persistent non-virus non-alcohol related elevation of aminotransferase levels: a rare case and review of the literature. Marmara Medical Journal 29 3 181–184.
IEEE G. Tazegul, N. Gunes, M. Akın, G. O. Elpek, and A. Boz, “Asymptomatic persistent non-virus non-alcohol related elevation of aminotransferase levels: a rare case and review of the literature”, Marmara Med J, vol. 29, no. 3, pp. 181–184, 2016, doi: 10.5472/MMJcr.2903.02.
ISNAD Tazegul, Gokhan et al. “Asymptomatic Persistent Non-Virus Non-Alcohol Related Elevation of Aminotransferase Levels: A Rare Case and Review of the Literature”. Marmara Medical Journal 29/3 (October 2016), 181-184. https://doi.org/10.5472/MMJcr.2903.02.
JAMA Tazegul G, Gunes N, Akın M, Elpek GO, Boz A. Asymptomatic persistent non-virus non-alcohol related elevation of aminotransferase levels: a rare case and review of the literature. Marmara Med J. 2016;29:181–184.
MLA Tazegul, Gokhan et al. “Asymptomatic Persistent Non-Virus Non-Alcohol Related Elevation of Aminotransferase Levels: A Rare Case and Review of the Literature”. Marmara Medical Journal, vol. 29, no. 3, 2016, pp. 181-4, doi:10.5472/MMJcr.2903.02.
Vancouver Tazegul G, Gunes N, Akın M, Elpek GO, Boz A. Asymptomatic persistent non-virus non-alcohol related elevation of aminotransferase levels: a rare case and review of the literature. Marmara Med J. 2016;29(3):181-4.