Research Article
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Year 2018, Volume: 31 Issue: 1, 1 - 10, 28.01.2018
https://doi.org/10.5472/marumj.342046

Abstract

References

  • Hunter JM. Recurrentcarpaltunnelsyndrome, epineuralfibrousfixation, andtractionneuropathy. HandClin 1991;7:491-504
  • Abercrombie M and Johnson ML. Collagencontent of rabbitsciatıcnerveduringwalleriandegeneration. J NeurolNeurosurgPsychiatry 1946;9:113-8.

The effect of topical 5-Fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve

Year 2018, Volume: 31 Issue: 1, 1 - 10, 28.01.2018
https://doi.org/10.5472/marumj.342046

Abstract

Objective: This study investigated the
effect of topical 5-Fluorouracil (5-FU) application on the epineural scar
tissue, which has a negative impact on the outcome after a peripheral nerve
surgery, and whether the application of two doses of 5-FU would change the
outcome.

     Materials and Methods: The study involved 72
3-month-old female Spradue-Dawey rats weighing 250-300 g each. After the
experimental animals were observed for a week to make certain that they were
healthy, they were randomly divided into 3 main groups; Group A: skin incision
+ epineurotomy + isotonic (n=24), Group B: skin incision + epineurotomy +
single dose of 5-FU (n=24) and Group C: skin incision + epineurotomy + two
doses of 5-FU (n=24). Each group was divided into 2 subgroups based on the
weeks in which they were examined. The two subgroups in each of the three
groups were made subject to a walking test, and macroscopic and histopathological
examinations at Week 4 and Week 8.

     Results: An evaluation of the
macroscopic results showed that there was a statistically significant difference
between Group A and Group C in sciatic nerve adhesion and severability of its
branches. We obtained better results in Group C,
  when compared 
with the results obtained in Group A.       







     Conclusion:
We demonstrated in our
study that 5-FU had a positive effect on the scar tissue developed around the
epineurectomized nerve. This positive effect was also reflected in the nerve’s
functional capacity, and a second dose of 5-FU application further improved
this effect.

References

  • Hunter JM. Recurrentcarpaltunnelsyndrome, epineuralfibrousfixation, andtractionneuropathy. HandClin 1991;7:491-504
  • Abercrombie M and Johnson ML. Collagencontent of rabbitsciatıcnerveduringwalleriandegeneration. J NeurolNeurosurgPsychiatry 1946;9:113-8.
There are 2 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Articles
Authors

Melekber Cavus Ozkan This is me

Betul Tuncel This is me

Guzin Yesim Ozgenel This is me

Publication Date January 28, 2018
Published in Issue Year 2018 Volume: 31 Issue: 1

Cite

APA Cavus Ozkan, M., Tuncel, B., & Ozgenel, G. Y. (2018). The effect of topical 5-Fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve. Marmara Medical Journal, 31(1), 1-10. https://doi.org/10.5472/marumj.342046
AMA Cavus Ozkan M, Tuncel B, Ozgenel GY. The effect of topical 5-Fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve. Marmara Med J. January 2018;31(1):1-10. doi:10.5472/marumj.342046
Chicago Cavus Ozkan, Melekber, Betul Tuncel, and Guzin Yesim Ozgenel. “The Effect of Topical 5-Fluorouracil Application on Epineural Scar Tissue in Epineurectomized Rat Sciatic Nerve”. Marmara Medical Journal 31, no. 1 (January 2018): 1-10. https://doi.org/10.5472/marumj.342046.
EndNote Cavus Ozkan M, Tuncel B, Ozgenel GY (January 1, 2018) The effect of topical 5-Fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve. Marmara Medical Journal 31 1 1–10.
IEEE M. Cavus Ozkan, B. Tuncel, and G. Y. Ozgenel, “The effect of topical 5-Fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve”, Marmara Med J, vol. 31, no. 1, pp. 1–10, 2018, doi: 10.5472/marumj.342046.
ISNAD Cavus Ozkan, Melekber et al. “The Effect of Topical 5-Fluorouracil Application on Epineural Scar Tissue in Epineurectomized Rat Sciatic Nerve”. Marmara Medical Journal 31/1 (January 2018), 1-10. https://doi.org/10.5472/marumj.342046.
JAMA Cavus Ozkan M, Tuncel B, Ozgenel GY. The effect of topical 5-Fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve. Marmara Med J. 2018;31:1–10.
MLA Cavus Ozkan, Melekber et al. “The Effect of Topical 5-Fluorouracil Application on Epineural Scar Tissue in Epineurectomized Rat Sciatic Nerve”. Marmara Medical Journal, vol. 31, no. 1, 2018, pp. 1-10, doi:10.5472/marumj.342046.
Vancouver Cavus Ozkan M, Tuncel B, Ozgenel GY. The effect of topical 5-Fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve. Marmara Med J. 2018;31(1):1-10.