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Efficacy of topical clobetasol propionate in the treatment of idiopathic granulomatous mastitis

Year 2018, Volume: 31 Issue: 3, 108 - 111, 31.10.2018
https://doi.org/10.5472/marumj.474170

Abstract

Objectives: To evaluate the efficacy of topical clobetasol
propionate 0.05% pomade in the treatment of idiopathic
granulomatous mastitis.
Patients and Methods: Twenty-one idiopathic granulomatous
mastitis patients’ clinical and histopathological findings were
retrospectively reviewed. Those patients excluded from other
etiologies were categorized as idiopathic granulomatous mastitis
and treated with topical clobetasol propionate 0.05% pomade as
an initial treatment.
Results: All 21 patients with a final diagnosis of idiopathic
granulomatous mastitis were women with the average age of
36.2+/-5.2 years. Of the 21 patients; erythema, induration and pain
problems of 6 (28.5%) patients totally resolved without recurrence
in 3 months follow-up period. Erythema, induration and pain
problems of 7 (33.5%) patients were minimalized and stay stable
in 3 months follow-up period. The symptoms of 8 (38%) did not
change under topical clobetasol propionate treatment. None of the
patients developed side or adverse effects due to topical steroid
treatment and 6 of 18 patients with non-steroidal anti-inflammatory
drugs (NSAIDs) complained of gastric pain.
Conclusion:Topical steroid treatment is a safe treatment option
for idiopathic granulomatous mastitis patients before systemic
steroid and immunosuppressive treatments and also surgery.

References

  • 1. Baslaim MM, Khayat HA, Al-Amoudi SA. Idiopathic granulomatous mastitis: a heterogenous disease with variable clinical presentations. World J Surg 2007; 31:1677-81. doi: 10.1007/s00268-007-9116-1
  • 2. Ocal K, Dag A, Turkmenoglu O, et al. Granulomatous mastitis: Clinical, pathological features and management. Breast J 2010; 16: 176-82. doi: 10.1111/j.1524-4741.2009.00879.x
  • 3. Yılmaz TU, Gürel B, Güler SA, et al. Scoring idiopathic granulomatous mastitis: an effective system for predicting recurrence? Eur J Breast Health 2018; 14:112-16. doi: 10.5152/ejbh.2018.3709
  • 4. Benson JR, Dumitru D. Idiopathic granulomatous mastitis: presentation, investigation and management. Future Oncol 2016;12: 1381-94. doi: 10.2217/fon-2015-0038
  • 5. Al-khaaf B, Knox F, Bundred NJ. Idiopathic granulomatous mastitis: a 25-year experince. J Am Coll Surg 2008; 206: 269-73. doi: 10.1016/j.jamcollsurg.2007.07.041
  • 6. Azlina AF, Ariza Z, Arni T, et al. Chronic granulomatous mastitis: diagnostic and therapeutic considerations. World J Surg 2003; 27: 515 – 18. doi: 10.1007/s00268-003-6806-1
  • 7. Moris D, Damaskos C, Davakis S, et al. Is idiopathic granulomatous mastitis a surgical disease? The jury is still out. Ann Transl Med 2017;5:309-13. doi: 10.21037/ atm.2017.05.24
  • 8. Kieffer P, Dukic R, Huiber M, et al. A young woman with granulomatous mastitis: a corynebacteria may be involved in the pathogenesis of this disease. Rev Med Intern 2006; 27: 550-4. doi: 10.1016/j.revmed.2006.03.033
  • 9. Cserni G, Szajki K. Granulomatous lobuler mastitis following drug-induced galactorrhea and blunt trauma. Breast J 1999;5:398-403.
  • 10. Lei X, Chen K, Zhu L, et al. Treatment for idiopathic granulomatous mastitis: systematic review and metaanalysis. Breastfeed Med 2017; 12:415-21. doi: 10.1089/ bfm.2017.0030
  • 11. Gumus M, Akkurt ZM, Gumus H. Is erythema nodosum coexisting with lesions of the breast a suggestive sign for idiopathic granulomatous mastitis? Turk J Surg 2018; 34:71- 3. doi: 10.5152/turkjsurg.2017.3161
  • 12. DeHertogh DA, Rossof AH, Harris AA. et al. Prednisone management of granulomatous mastitis. N Engl J Med 1980; 303:799-800. doi: 10.1056/NEJM198010023031406
  • 13. Altıntoprak F. Topical steroids to treat granulomatous mastitis: A case report. Korean J Intern Med 2011; 26:356-9. doi: 10.3904/kjim.2011.26.3.356
  • 14. Gunduz Y, Antıntoprak F, Ayhan LT, et al. Effect of topical steroid treatment on Idiopathic Granulomatous Mastitis: clinical and radiological evaluation. The Breast J 2014;20:586-91. doi: 10.1111/tbj.12335
  • 15. Altıntoprak F, Kıvılcım, Yalkın O, et al. Topical steroids are effective in the treatment of Idiopathic Granulomatous mastitis. World J Surg 2015;39: 2718-23. doi: 10.1007/ s00268-015-3147-9
  • 16. Pandey TS, Mackinnon JC, Bressler L, et al. Idiopathic granulomatous mastitis-a prospective study of 49 woman and treatment outcomes with steroid therapy. Breast J 2014; 20:258-66. doi: 10.1111/tbj.12263
  • 17. Bouton ME, Jayaram L, O’Neill PJ, et al. Management of idiopathic granulomatous mastitis with observation. Am J Surg 2015; 210: 258-62. doi:10.1016/j.amjsurg.2014.08.044
  • 18. Mahlab-Guri K, Asher I, Allweis T, et al. Granulomatous lobular mastitis. Isr Med Assoc J 2015; 17:476-80.
  • 19. Hur SM, Cho DH, Lee SK, et al. Experience of treatment of patients with granulomatous lobular mastitis. J Korean Surg Soc 2013;85:1-6. doi: 10.4174/jkss.2013.85.1.1

İdiyopatik granülomatöz mastit tedavisinde yerel klobetazol propionatın etkinliği

Year 2018, Volume: 31 Issue: 3, 108 - 111, 31.10.2018
https://doi.org/10.5472/marumj.474170

Abstract

Amaç: İdiyopatik granulomatöz mastit tedavisinde topikal
klobetazol propiyonat %0,05 pomadın etkinliğini değerlendirmek.
Hastalar ve Yöntemler: Klinik ve histopatolojik olarak
idiyopatik granülomatöz mastit tanısı konulan 21 hastanın
dosyası retrospektif olarak incelendi. Altta yatan başka patoloji
saptanmayan hastalar idiyopatik granülomatöz mastit olarak
sınıflandırıldı ve ilk tedavi olarak topikal klobetazol propiyonat %
0,05 pomad uygulandı.
Bulgular: İdiyopatik granülomatöz mastit tanılı 21 kadın
hastanın yaş ortalaması 36,2 ± 5,2 yıldı. Yirmi bir hastanın 6 (%
28,5)’sının eritem, sertlik ve ağrı problemleri tamamen geriledi ve
3 aylık takip döneminde tekrarlamadı. Hastaların 7 (% 33,5)’sinde
eritem, sertlik ve ağrı şikayetleri tama yakın geriledi ve 3 ay
süreli takiplerinde artış izlenmedi. Sekiz (%38) hastada iyileşme
gözlenmedi. Hastalarda yerel steroid tedavisine bağlı yan etki
görülmezken, ek olarak non-steroid antiinflamatuvar (NSAI) ilaç
kullanan 18 hastanın 6’sında mide ağrısı şikayetleri gelişti.
Sonuç: Yerel steroid tedavileri idiyopatik granülomatöz mastit
tedavisinde etkili ve güvenli tedavi seçenekleridir.

References

  • 1. Baslaim MM, Khayat HA, Al-Amoudi SA. Idiopathic granulomatous mastitis: a heterogenous disease with variable clinical presentations. World J Surg 2007; 31:1677-81. doi: 10.1007/s00268-007-9116-1
  • 2. Ocal K, Dag A, Turkmenoglu O, et al. Granulomatous mastitis: Clinical, pathological features and management. Breast J 2010; 16: 176-82. doi: 10.1111/j.1524-4741.2009.00879.x
  • 3. Yılmaz TU, Gürel B, Güler SA, et al. Scoring idiopathic granulomatous mastitis: an effective system for predicting recurrence? Eur J Breast Health 2018; 14:112-16. doi: 10.5152/ejbh.2018.3709
  • 4. Benson JR, Dumitru D. Idiopathic granulomatous mastitis: presentation, investigation and management. Future Oncol 2016;12: 1381-94. doi: 10.2217/fon-2015-0038
  • 5. Al-khaaf B, Knox F, Bundred NJ. Idiopathic granulomatous mastitis: a 25-year experince. J Am Coll Surg 2008; 206: 269-73. doi: 10.1016/j.jamcollsurg.2007.07.041
  • 6. Azlina AF, Ariza Z, Arni T, et al. Chronic granulomatous mastitis: diagnostic and therapeutic considerations. World J Surg 2003; 27: 515 – 18. doi: 10.1007/s00268-003-6806-1
  • 7. Moris D, Damaskos C, Davakis S, et al. Is idiopathic granulomatous mastitis a surgical disease? The jury is still out. Ann Transl Med 2017;5:309-13. doi: 10.21037/ atm.2017.05.24
  • 8. Kieffer P, Dukic R, Huiber M, et al. A young woman with granulomatous mastitis: a corynebacteria may be involved in the pathogenesis of this disease. Rev Med Intern 2006; 27: 550-4. doi: 10.1016/j.revmed.2006.03.033
  • 9. Cserni G, Szajki K. Granulomatous lobuler mastitis following drug-induced galactorrhea and blunt trauma. Breast J 1999;5:398-403.
  • 10. Lei X, Chen K, Zhu L, et al. Treatment for idiopathic granulomatous mastitis: systematic review and metaanalysis. Breastfeed Med 2017; 12:415-21. doi: 10.1089/ bfm.2017.0030
  • 11. Gumus M, Akkurt ZM, Gumus H. Is erythema nodosum coexisting with lesions of the breast a suggestive sign for idiopathic granulomatous mastitis? Turk J Surg 2018; 34:71- 3. doi: 10.5152/turkjsurg.2017.3161
  • 12. DeHertogh DA, Rossof AH, Harris AA. et al. Prednisone management of granulomatous mastitis. N Engl J Med 1980; 303:799-800. doi: 10.1056/NEJM198010023031406
  • 13. Altıntoprak F. Topical steroids to treat granulomatous mastitis: A case report. Korean J Intern Med 2011; 26:356-9. doi: 10.3904/kjim.2011.26.3.356
  • 14. Gunduz Y, Antıntoprak F, Ayhan LT, et al. Effect of topical steroid treatment on Idiopathic Granulomatous Mastitis: clinical and radiological evaluation. The Breast J 2014;20:586-91. doi: 10.1111/tbj.12335
  • 15. Altıntoprak F, Kıvılcım, Yalkın O, et al. Topical steroids are effective in the treatment of Idiopathic Granulomatous mastitis. World J Surg 2015;39: 2718-23. doi: 10.1007/ s00268-015-3147-9
  • 16. Pandey TS, Mackinnon JC, Bressler L, et al. Idiopathic granulomatous mastitis-a prospective study of 49 woman and treatment outcomes with steroid therapy. Breast J 2014; 20:258-66. doi: 10.1111/tbj.12263
  • 17. Bouton ME, Jayaram L, O’Neill PJ, et al. Management of idiopathic granulomatous mastitis with observation. Am J Surg 2015; 210: 258-62. doi:10.1016/j.amjsurg.2014.08.044
  • 18. Mahlab-Guri K, Asher I, Allweis T, et al. Granulomatous lobular mastitis. Isr Med Assoc J 2015; 17:476-80.
  • 19. Hur SM, Cho DH, Lee SK, et al. Experience of treatment of patients with granulomatous lobular mastitis. J Korean Surg Soc 2013;85:1-6. doi: 10.4174/jkss.2013.85.1.1
There are 19 citations in total.

Details

Primary Language English
Journal Section Articles
Authors

Züleyha Yazıcı Özgen This is me

Elif Cömert This is me

Mustafa Ümit Uğurlu This is me

Publication Date October 31, 2018
Published in Issue Year 2018 Volume: 31 Issue: 3

Cite

APA Yazıcı Özgen, Z., Cömert, E., & Uğurlu, M. Ü. (2018). Efficacy of topical clobetasol propionate in the treatment of idiopathic granulomatous mastitis. Marmara Medical Journal, 31(3), 108-111. https://doi.org/10.5472/marumj.474170
AMA Yazıcı Özgen Z, Cömert E, Uğurlu MÜ. Efficacy of topical clobetasol propionate in the treatment of idiopathic granulomatous mastitis. Marmara Med J. October 2018;31(3):108-111. doi:10.5472/marumj.474170
Chicago Yazıcı Özgen, Züleyha, Elif Cömert, and Mustafa Ümit Uğurlu. “Efficacy of Topical Clobetasol Propionate in the Treatment of Idiopathic Granulomatous Mastitis”. Marmara Medical Journal 31, no. 3 (October 2018): 108-11. https://doi.org/10.5472/marumj.474170.
EndNote Yazıcı Özgen Z, Cömert E, Uğurlu MÜ (October 1, 2018) Efficacy of topical clobetasol propionate in the treatment of idiopathic granulomatous mastitis. Marmara Medical Journal 31 3 108–111.
IEEE Z. Yazıcı Özgen, E. Cömert, and M. Ü. Uğurlu, “Efficacy of topical clobetasol propionate in the treatment of idiopathic granulomatous mastitis”, Marmara Med J, vol. 31, no. 3, pp. 108–111, 2018, doi: 10.5472/marumj.474170.
ISNAD Yazıcı Özgen, Züleyha et al. “Efficacy of Topical Clobetasol Propionate in the Treatment of Idiopathic Granulomatous Mastitis”. Marmara Medical Journal 31/3 (October 2018), 108-111. https://doi.org/10.5472/marumj.474170.
JAMA Yazıcı Özgen Z, Cömert E, Uğurlu MÜ. Efficacy of topical clobetasol propionate in the treatment of idiopathic granulomatous mastitis. Marmara Med J. 2018;31:108–111.
MLA Yazıcı Özgen, Züleyha et al. “Efficacy of Topical Clobetasol Propionate in the Treatment of Idiopathic Granulomatous Mastitis”. Marmara Medical Journal, vol. 31, no. 3, 2018, pp. 108-11, doi:10.5472/marumj.474170.
Vancouver Yazıcı Özgen Z, Cömert E, Uğurlu MÜ. Efficacy of topical clobetasol propionate in the treatment of idiopathic granulomatous mastitis. Marmara Med J. 2018;31(3):108-11.