Tavşan kulak kıkırdağında distraksiyon kondroneogenezisi

Fatma Nihal Kocaaslan; Özhan Çelebiler; Ayhan Numanoğlu; Hüseyin Kemal Türköz

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Year 2013, Volume: 26 Issue: 3, 136 - 141, 30.09.2015

Fatma Nihal Kocaaslan Özhan Çelebiler Ayhan Numanoğlu Hüseyin Kemal Türköz

Abstract

Objective: Application of distraction is an alternative to bone graft or flap operations for repairing bone defects. Bone can be extended in width and length without using a new donor area. Operation time is shortened and failures are reduced without any concern about graft or flap loss. However, there are no distraction methods known for generating new cartilage as an alternative to graft or flap applications in repairs of cartilage defects This experimental study was planned to determine whether or not chondroneogenesis can be obtained via application of distraction.Methods: Fourteen New Zealand rabbits were used in this study. Distractions at a rate of 0.50 mm/day, 0.25 mm/day and 0.25 mm on alternate days were applied on 3 rabbits consecutively and the ideal distraction rate was determined as 0.25 mm once every two days. On alternate days 0.25 mm of distraction was applied for two months aiming to generate 7.5 mm of new cartilage. Results: In the rabbits in which 0.25 mm of distraction on alternate days had been applied, regular new cartilage formation was observed.Conclusions: According to these findings, the slow metabolic rate of avascular cartilage tissue affects distraction rates and rhythms. However, by applying distraction and taking advantage of the regenerative capacity of the perichondrium, it is possible to generate new and regular chondrocytes and extend the cartilage.

Keywords

Cartilage, Distraction, Rabbit.

References

1. Tsuchiya H, Tomita K. Distraction osteogenesis for treatment of bone loss in the lower extremity. J Orthop Sci 2003;81:116-24. doi: 10.1007/ s007760300020
2. Eren A, Eralp L. Çakmak M (editors) et al. Ilizarov cerrahisi ve prensipleri: Ilizarov sisteminin dünyada ve Türkiye’de gelişimi. İstanbul: Doruk Grafik, 1999.
3. De Bastiani G, Aldegheri R, Renzi-Brivio L, et al. Limb lengthening by callus distraction (callotasis). J Pediatr Orthop 1987;7:129-34. doi: 10.1097/01241398-198703000-00002
4. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues: Part 1. The influence of stability of fixation and soft-tissue preservation. Clin Orthop 1988;238:249-81.
5. Kürklü M. Periferik Sinir Defektlerinin Tedavisinde; Primer Tamir, Distraksiyon ve Greftleme Yöntemlerinin Karşılaştırılması. Gülhane Askeri Tıp Akademisi Askeri Tıp Fakültesi, Ortopedi ve Travmatoloji Uzmanlık Tezi, Ankara, 2003.
6. Markus K, Frank U, Thorsten G, et al. Effects of controlled dynamic disc distraction on degenerated intervertebral discs: An in vivo study on the rabbit lumbar spine model. Spine 2005;30:181-7.
7. Molina F, Ortiz Monasterio F, Aguilar M, et al. Maxillary distraction: aesthetic and functional benefits in cleft lip-palat and prognathic patiens during mixed dentition. Plast Reconstr Surg 1998;4:951-63. doi: 10.1097/00006534-199804040-00010
8. Kessler P, Wiltfang J, Schultze-Mosgau S, et al. Distraction osteogenesis of the maxilla and midface using a subcutaneous device: report of four cases. Br J Oral Maxillofac Surg 2001;39:13-21.
9. Chin M, Toth BA. Le Fort III advancement with gradual distraction using internal devices. Plast Reconstr Surg 1997;100:819-30. doi: 10.1097/00006534-199709001-00001
10. Lester CW. Tissue replacement after subperichondrial resection of costal cartilage: Two case reports. Plast Reconstr Surg 1959;23:49–54. doi: 10.1097/00006534-195901000-00006
11. Maor G, Von Der Mark K, Reddi H. Acceleration of cartilage and bone differentiation on collagenous substrata. Collagen Rel Res 1987;7:351-70.
12. Fawcett DW. Cartilage. In: Fawcett DW, editor. A Textbook of Histology. 11th Edition. Philadelphia:WB Saunders, 1986: 188-9.
13. Ohlsen L, Vedung S. Reconstructing the antihelix of protruding ears by perichondrioplasty: a modified technique. Plast Reconstr Surg 1980;65:753-62 doi: 10.1097/00006534-198006000-00007.
14. Skoog T, Ohlsen L, Sohn SA. Perichondrial potential for cartilagenous regeneration. Scand J Plast Reconstr Surg 1972;6:123-5. doi: 10.3109/02844317209036711
15. Rasmussen S, Sonne-Holm S. Bone lengthening. History of the development and field of applications. Ugeskr Laeger 1999 Aug 30;161:4863-7.
16. Junqueria LC, Carneiro J, Kelley RO. Temel Histoloji. Çev: Aytekin Y, Solakoğlu S, Ahıskalı B. İstanbul: Barış Kitabevi, 1995: 124-31.
17. Al Ruhaimi KA. Comparison of different distraction rates in the mandible: An experimental investigation. Int J Oral Maxillofac Surg 2001;30:220-6. doi: 10.1054/ijom.2001.0046
18. Ilizarov GA. Clinical application at the tension-stress effect for limb lengthening. Clin Orthop 1990;250:8-17. doi: 10.1097/00003086- 199001000-00003
19. Tavakoli K, Stewart KJ. Poole MD. Distraction osteogenesis icraniofacial surgery; A review. Ann Plast Surg 1998;40:88-99. doi: 10.1097/00000637-199801000-00020
20. Karaharju-Suvonto T, Peltonen J, Karaharju EO. Distraction osteogenesis of the mandible. J Oral Maxillofac Surg 1992;21:118-21. doi: 10.1016/S0901-5027(05)80547-8
21. Al-Mahdi AH, Al-Jumaily HA. Clinical evaluation of distraction osteogenesis in the treatment of mandibular hypoplasia. J Craniofac Surg 2013;24:e50-7. doi: 10.1097/SCS.0b013e3182700223.
22. Yasui N, Kojimoto H, Sasaki K, et al. Shimizu H, Shimomura Y. Factors affecting callus distraction in limb lengthening. Clin Orthop Rel Res 1993;293:55-60. doi: 10.1097/00003086-199308000-00008
23. Gil-Albarova J, de Pablos J, Franzeb M, et al. Delayed distraction in bone lengthening. Improved healing in lambs. Acta Orthop Scand 1992;6:604-6. doi: 10.1080/17453679209169717
24. Cope JB, Samchukov ML, Cherkashin AM. Craniofacial distraction osteogenesis. In: Samchukov ML, Cope JB, Cherkashin AM, editors. Historical Development and Evoluation of Craniofacial Distraction Osteogenesis. Missouri: Mosby, 2001;3-18.
25. Ross MH, Romrell LJ, Kaye GI, (editors). Histology A Text and Atlas. 3rd Edition. Philedelphia: Lippincott, Williams and Wilkins, 1995:132-48.
26. Goode RL. Bone and cartilage grafts: Current concepts. Otolaryngol Clin North Am 1972;5:447-55.
27. Donald PJ, Col A. Cartilage implantation in head and neck surgery: Report of a national survey. Otolaryngol Head and Neck Surg 1982;90:85-9.
28. Brown DL, Borschel GH (editors). Michigan Manual of Plastic Surgery. Philadelphia: Lippincott, Williams and Wilkins, 2004.
29. Kashiwa K, Koyayashi S, Nohara T, et al. Efficacy of distraction steogenesis for mandibular reconstruction in Previously Irradiated areas: Clinical experiences. J Craniofac Surg 2008;19:1571-6.
30. Price DL, Moore EJ, Friedman O, et al. Furutani KM. Effect of radiation on segmental distraction osteogenesiz in rabbits. Arch Facial Plast Surg 2008;10:159-63. doi: 10.1001/archfaci.10.3.159

Tavşan kulak kıkırdağında distraksiyon kondroneogenezisi

Year 2013, Volume: 26 Issue: 3, 136 - 141, 30.09.2015

Fatma Nihal Kocaaslan Özhan Çelebiler Ayhan Numanoğlu Hüseyin Kemal Türköz

Abstract

Amaç: Distraksiyon, kemik defektlerinin onarımı için kullanılan,
kemik grefti ya da flebi ameliyatlarına alternatif bir uygulamadır.
Yeni bir donör alan kullanılmadan kemik hem enine hem de
boyuna uzatılabilmektedir. Ameliyat süresi kısalmakta ve greft
veya flep kaybı endişesi olmaksızın başarısızlık düşmektedir.
Oysa kıkırdak defekti onarımında greft ya da flep uygulamasına
alternatif olarak yeni kıkırdak oluşturacak bir distraksiyon yöntemi
bilinmemektedir. Distraksiyon yöntemi ile kondroneogenezis
oluşturulup oluşturulamayacağını araştırmak amacıyla bu deneysel
çalışma planlanmıştır.
Yöntem: Bu çalışmada toplam 14 adet Yeni Zelanda tavşanı
kullanıldı. Ardışık 3 adet tavşanda 0,50 mm/gün, 0,25 mm/gün ve
günaşırı 0,25 mm’lik distraksiyonlar yapıldı ve ideal distraksiyon
hızının iki günde bir kez 0,25 mm olmasına karar verildi. İki ay
boyunca gün aşırı 0,25 mm distraksiyon uygulandı ve toplam 7,5
mm yeni kıkırdak oluşması planlandı.
Bulgular: Günaşırı 0,25 mm hızda distraksiyon yapılan
hayvanlarda distraksiyon alanında düzenli yeni kıkırdak dokusu
oluşumu izlendi.
Sonuç: Bu deneysel çalışmada elde edilen bulgulara göre,
avasküler kıkırdak dokusunun metabolizmasının yavaş olması,
distraksiyon hızını ve ritmini etkilemektedir. Ancak distraksiyon
yöntemiyle, perikondriumun rejenerasyon kapasitesinden de
faydalanılarak, yeni ve düzenli kondrosit oluşturmak ve kıkırdağı
uzatabilmek mümkündür.

Keywords

Kıkırdak, Distraksiyon, Tavşan

References

1. Tsuchiya H, Tomita K. Distraction osteogenesis for treatment of bone loss in the lower extremity. J Orthop Sci 2003;81:116-24. doi: 10.1007/ s007760300020
2. Eren A, Eralp L. Çakmak M (editors) et al. Ilizarov cerrahisi ve prensipleri: Ilizarov sisteminin dünyada ve Türkiye’de gelişimi. İstanbul: Doruk Grafik, 1999.
3. De Bastiani G, Aldegheri R, Renzi-Brivio L, et al. Limb lengthening by callus distraction (callotasis). J Pediatr Orthop 1987;7:129-34. doi: 10.1097/01241398-198703000-00002
4. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues: Part 1. The influence of stability of fixation and soft-tissue preservation. Clin Orthop 1988;238:249-81.
5. Kürklü M. Periferik Sinir Defektlerinin Tedavisinde; Primer Tamir, Distraksiyon ve Greftleme Yöntemlerinin Karşılaştırılması. Gülhane Askeri Tıp Akademisi Askeri Tıp Fakültesi, Ortopedi ve Travmatoloji Uzmanlık Tezi, Ankara, 2003.
6. Markus K, Frank U, Thorsten G, et al. Effects of controlled dynamic disc distraction on degenerated intervertebral discs: An in vivo study on the rabbit lumbar spine model. Spine 2005;30:181-7.
7. Molina F, Ortiz Monasterio F, Aguilar M, et al. Maxillary distraction: aesthetic and functional benefits in cleft lip-palat and prognathic patiens during mixed dentition. Plast Reconstr Surg 1998;4:951-63. doi: 10.1097/00006534-199804040-00010
8. Kessler P, Wiltfang J, Schultze-Mosgau S, et al. Distraction osteogenesis of the maxilla and midface using a subcutaneous device: report of four cases. Br J Oral Maxillofac Surg 2001;39:13-21.
9. Chin M, Toth BA. Le Fort III advancement with gradual distraction using internal devices. Plast Reconstr Surg 1997;100:819-30. doi: 10.1097/00006534-199709001-00001
10. Lester CW. Tissue replacement after subperichondrial resection of costal cartilage: Two case reports. Plast Reconstr Surg 1959;23:49–54. doi: 10.1097/00006534-195901000-00006
11. Maor G, Von Der Mark K, Reddi H. Acceleration of cartilage and bone differentiation on collagenous substrata. Collagen Rel Res 1987;7:351-70.
12. Fawcett DW. Cartilage. In: Fawcett DW, editor. A Textbook of Histology. 11th Edition. Philadelphia:WB Saunders, 1986: 188-9.
13. Ohlsen L, Vedung S. Reconstructing the antihelix of protruding ears by perichondrioplasty: a modified technique. Plast Reconstr Surg 1980;65:753-62 doi: 10.1097/00006534-198006000-00007.
14. Skoog T, Ohlsen L, Sohn SA. Perichondrial potential for cartilagenous regeneration. Scand J Plast Reconstr Surg 1972;6:123-5. doi: 10.3109/02844317209036711
15. Rasmussen S, Sonne-Holm S. Bone lengthening. History of the development and field of applications. Ugeskr Laeger 1999 Aug 30;161:4863-7.
16. Junqueria LC, Carneiro J, Kelley RO. Temel Histoloji. Çev: Aytekin Y, Solakoğlu S, Ahıskalı B. İstanbul: Barış Kitabevi, 1995: 124-31.
17. Al Ruhaimi KA. Comparison of different distraction rates in the mandible: An experimental investigation. Int J Oral Maxillofac Surg 2001;30:220-6. doi: 10.1054/ijom.2001.0046
18. Ilizarov GA. Clinical application at the tension-stress effect for limb lengthening. Clin Orthop 1990;250:8-17. doi: 10.1097/00003086- 199001000-00003
19. Tavakoli K, Stewart KJ. Poole MD. Distraction osteogenesis icraniofacial surgery; A review. Ann Plast Surg 1998;40:88-99. doi: 10.1097/00000637-199801000-00020
20. Karaharju-Suvonto T, Peltonen J, Karaharju EO. Distraction osteogenesis of the mandible. J Oral Maxillofac Surg 1992;21:118-21. doi: 10.1016/S0901-5027(05)80547-8
21. Al-Mahdi AH, Al-Jumaily HA. Clinical evaluation of distraction osteogenesis in the treatment of mandibular hypoplasia. J Craniofac Surg 2013;24:e50-7. doi: 10.1097/SCS.0b013e3182700223.
22. Yasui N, Kojimoto H, Sasaki K, et al. Shimizu H, Shimomura Y. Factors affecting callus distraction in limb lengthening. Clin Orthop Rel Res 1993;293:55-60. doi: 10.1097/00003086-199308000-00008
23. Gil-Albarova J, de Pablos J, Franzeb M, et al. Delayed distraction in bone lengthening. Improved healing in lambs. Acta Orthop Scand 1992;6:604-6. doi: 10.1080/17453679209169717
24. Cope JB, Samchukov ML, Cherkashin AM. Craniofacial distraction osteogenesis. In: Samchukov ML, Cope JB, Cherkashin AM, editors. Historical Development and Evoluation of Craniofacial Distraction Osteogenesis. Missouri: Mosby, 2001;3-18.
25. Ross MH, Romrell LJ, Kaye GI, (editors). Histology A Text and Atlas. 3rd Edition. Philedelphia: Lippincott, Williams and Wilkins, 1995:132-48.
26. Goode RL. Bone and cartilage grafts: Current concepts. Otolaryngol Clin North Am 1972;5:447-55.
27. Donald PJ, Col A. Cartilage implantation in head and neck surgery: Report of a national survey. Otolaryngol Head and Neck Surg 1982;90:85-9.
28. Brown DL, Borschel GH (editors). Michigan Manual of Plastic Surgery. Philadelphia: Lippincott, Williams and Wilkins, 2004.
29. Kashiwa K, Koyayashi S, Nohara T, et al. Efficacy of distraction steogenesis for mandibular reconstruction in Previously Irradiated areas: Clinical experiences. J Craniofac Surg 2008;19:1571-6.
30. Price DL, Moore EJ, Friedman O, et al. Furutani KM. Effect of radiation on segmental distraction osteogenesiz in rabbits. Arch Facial Plast Surg 2008;10:159-63. doi: 10.1001/archfaci.10.3.159

There are 30 citations in total.

Details

Primary Language	Turkish
Journal Section	Articles
Authors	Fatma Nihal Kocaaslan This is me Özhan Çelebiler This is me Ayhan Numanoğlu This is me Hüseyin Kemal Türköz This is me
Publication Date	September 30, 2015
Published in Issue	Year 2013 Volume: 26 Issue: 3

Cite

APA	Kocaaslan, F. N., Çelebiler, Ö., Numanoğlu, A., Türköz, H. K. (2015). Tavşan kulak kıkırdağında distraksiyon kondroneogenezisi. Marmara Medical Journal, 26(3), 136-141.
AMA	Kocaaslan FN, Çelebiler Ö, Numanoğlu A, Türköz HK. Tavşan kulak kıkırdağında distraksiyon kondroneogenezisi. Marmara Med J. September 2015;26(3):136-141.
Chicago	Kocaaslan, Fatma Nihal, Özhan Çelebiler, Ayhan Numanoğlu, and Hüseyin Kemal Türköz. “Tavşan Kulak kıkırdağında Distraksiyon Kondroneogenezisi”. Marmara Medical Journal 26, no. 3 (September 2015): 136-41.
EndNote	Kocaaslan FN, Çelebiler Ö, Numanoğlu A, Türköz HK (September 1, 2015) Tavşan kulak kıkırdağında distraksiyon kondroneogenezisi. Marmara Medical Journal 26 3 136–141.
IEEE	F. N. Kocaaslan, Ö. Çelebiler, A. Numanoğlu, and H. K. Türköz, “Tavşan kulak kıkırdağında distraksiyon kondroneogenezisi”, Marmara Med J, vol. 26, no. 3, pp. 136–141, 2015.
ISNAD	Kocaaslan, Fatma Nihal et al. “Tavşan Kulak kıkırdağında Distraksiyon Kondroneogenezisi”. Marmara Medical Journal 26/3 (September 2015), 136-141.
JAMA	Kocaaslan FN, Çelebiler Ö, Numanoğlu A, Türköz HK. Tavşan kulak kıkırdağında distraksiyon kondroneogenezisi. Marmara Med J. 2015;26:136–141.
MLA	Kocaaslan, Fatma Nihal et al. “Tavşan Kulak kıkırdağında Distraksiyon Kondroneogenezisi”. Marmara Medical Journal, vol. 26, no. 3, 2015, pp. 136-41.
Vancouver	Kocaaslan FN, Çelebiler Ö, Numanoğlu A, Türköz HK. Tavşan kulak kıkırdağında distraksiyon kondroneogenezisi. Marmara Med J. 2015;26(3):136-41.

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