Abstract
Non immune hydrops fetalis is defined as the excessive accumulation of fluid in two or more compartments of the fetus in the absence of any maternal-fetal blood incompatibility. The clinical presentations include ascites, scalp edema, pleural or pericardial effusions and polyhydramnios. Perinatal mortality in this severe clinical condition is high, between 50-98%. Prematurity is an important risk factor for mortality. Despite many advances in diagnosis, therapy and ventilation management during the last decade in neonatal intensive care units, the mortality rate has not changed very much for hydropic infants. This is the report of the management of two premature infants born severely hydropic. The first infant had tachyarrhythmia, the second infant had Noonan syndrome. Both infants had a good prognosis.
References
- 1. Czernik C, Proquitté H, Metze B, Bührer C J. Hydrops fetalis-has there been a change in diagnostic spectrum and mortality? Matern Fetal Neonatal Med 2011;24:258-63. doi: 10.3109/14767058.2011.580401.
- 2. Sohan K, Carroll SG, De La Fuente S, et al. Analysis of outcome in hydrops fetalis in relation to gestational age at diagnosis, cause and treatment. Acta Obstet Gynecol Scand 2001; 80:726-30.
- 3. Etches P, Demianczuk N, Chari R. Non-immune hydrops fetalis. In: Rennie J M, editor. Roberton’s Textbook of Neonatology. 4th edition. Philadelphia: Elsevier’s, 2005:773-82.
- 4. Romano AA, Allanson JE, Dahlgren J, et al. Noonan syndrome: clinical features, diagnosis, and management guidelines. Pediatrics 2010;126:746-59. doi: 10.1542/peds.2009-3207.
- 5. Kleinman CS, Nehgme R, Copel JA. Fetal cardiac arrhythmias: diagnosis and therapy. In: Creasy RK, Resnik R, editors. MaternalFetal Medicine Principles and Practice. 5th edition. Philadelphia: Saunders, 2004: 465-82.
- 6. Jaeggi ET, Carvalho JS, De Groot E, et al. Comparison of transplacental treatment of fetal supraventricular tachyarrhythmias with digoxin, flecainide, and sotalol: results of a nonrandomized multicenter study. Circulation 2011;124:1747-54. doi: 10.1161/ CIRCULATIONAHA.111.026120.
- 7. Yinon Y, Grisaru-Granovsky S, Chaddha V, et al. Perinatal outcome following fetal chest shunt insertion for pleural effusion. Ultrasound Obstet Gynecol 2010;36:58-64. doi: 10.1002/uog.7507.
- 8. Santo S, Mansour S, Thilaganathan B, et al. Prenatal diagnosis of nonimmune hydrops fetalis: what do we tell the parents? Prenat Diagn 2011;31:186-95. doi: 10.1002/pd.2677
- 9. Fukushima K, Morokuma S, Fujita Y, et al. Short-term and long-term outcomes of 214 cases of non-immune hydrops fetalis. Early Hum Dev 2011;87:571-5. doi: 10.1016/j.earlhumdev.2011.04.015.
- 10. Castillo RA, Devoe LD, Hadi HA, et al. Nonimmune hydrops fetalis: clinical experience and factors related to a poor outcome. Am J Obstet Gynecol 1986; 155:812-6.
- 11. Wy CA, Sajous CH, Loberiza F, et al. Outcome of infants with a diagnosis of hydrops fetalis in the 1990s. Am J Perinatol 1999;16:561-7.
Abstract
Non immun hidrops fetalis anne ve bebek arasında kan uyuşmazlığı
olmaksızın fetüsde iki veya daha fazla vücut boşluğunda fazla sıvı
birikmesi olarak tanımlanır. Asit, saçlı deride ödem, plevral ve
perikardiyal efüzyon ve polihidramnios klinik tabloyu oluşturur. Bu
ağır klinik tabloda perinatal mortalite %50-98 arasında yüksektir.
Prematüre doğum mortalite için önemli bir risk faktörüdür.
Yenidoğan yoğun bakım ünitelerinde son on yılda tanı, tedavi
ve ventilasyon uygulamalarındaki gelişmelere rağmen, hidropik
bebeklerde mortalite oranları fazla değişmemiştir. Bu yazıda
hidropik doğan iki prematüre bebeğin takibi sunulmuştur. Birinci
olguda fetal taşiaritmiye, ikinci olguda Noonan sendromuna bağlı
non immun hidrops fetalis gelişmiştir. İki vakada da prognoz iyi
olmuştur.
References
- 1. Czernik C, Proquitté H, Metze B, Bührer C J. Hydrops fetalis-has there been a change in diagnostic spectrum and mortality? Matern Fetal Neonatal Med 2011;24:258-63. doi: 10.3109/14767058.2011.580401.
- 2. Sohan K, Carroll SG, De La Fuente S, et al. Analysis of outcome in hydrops fetalis in relation to gestational age at diagnosis, cause and treatment. Acta Obstet Gynecol Scand 2001; 80:726-30.
- 3. Etches P, Demianczuk N, Chari R. Non-immune hydrops fetalis. In: Rennie J M, editor. Roberton’s Textbook of Neonatology. 4th edition. Philadelphia: Elsevier’s, 2005:773-82.
- 4. Romano AA, Allanson JE, Dahlgren J, et al. Noonan syndrome: clinical features, diagnosis, and management guidelines. Pediatrics 2010;126:746-59. doi: 10.1542/peds.2009-3207.
- 5. Kleinman CS, Nehgme R, Copel JA. Fetal cardiac arrhythmias: diagnosis and therapy. In: Creasy RK, Resnik R, editors. MaternalFetal Medicine Principles and Practice. 5th edition. Philadelphia: Saunders, 2004: 465-82.
- 6. Jaeggi ET, Carvalho JS, De Groot E, et al. Comparison of transplacental treatment of fetal supraventricular tachyarrhythmias with digoxin, flecainide, and sotalol: results of a nonrandomized multicenter study. Circulation 2011;124:1747-54. doi: 10.1161/ CIRCULATIONAHA.111.026120.
- 7. Yinon Y, Grisaru-Granovsky S, Chaddha V, et al. Perinatal outcome following fetal chest shunt insertion for pleural effusion. Ultrasound Obstet Gynecol 2010;36:58-64. doi: 10.1002/uog.7507.
- 8. Santo S, Mansour S, Thilaganathan B, et al. Prenatal diagnosis of nonimmune hydrops fetalis: what do we tell the parents? Prenat Diagn 2011;31:186-95. doi: 10.1002/pd.2677
- 9. Fukushima K, Morokuma S, Fujita Y, et al. Short-term and long-term outcomes of 214 cases of non-immune hydrops fetalis. Early Hum Dev 2011;87:571-5. doi: 10.1016/j.earlhumdev.2011.04.015.
- 10. Castillo RA, Devoe LD, Hadi HA, et al. Nonimmune hydrops fetalis: clinical experience and factors related to a poor outcome. Am J Obstet Gynecol 1986; 155:812-6.
- 11. Wy CA, Sajous CH, Loberiza F, et al. Outcome of infants with a diagnosis of hydrops fetalis in the 1990s. Am J Perinatol 1999;16:561-7.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Reports |
| Authors | |
| Publication Date | September 30, 2015 |
| Published in Issue | Year 2013 Volume: 26 Issue: 3 |
