Year 2012, Volume 25 , Issue 1, Pages 10 - 16 2015-02-25

The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year
Bir Yıl Sonunda Şehirde Yaşayan Türk Kadınındaki Human Papilloma Virus Persistans ve Klereansı

Tevfik YOLDEMİR [1] , Funda EREN [2] , Mithat ERENUS [3]


Objective: To evaluate the persistence of the different human papillomavirus
(HPV) genotypes in women detected positive for HPV at Marmara University
Hospital gynecologic outpatient clinics.
Patients and Methods: Forty out of 79 women who had been tested
positive for HPV DNA in our initial prevalance study were re-assessed after
one year. HPV types were identified by polymerase chain reaction (PCR)
and hybridization using a microarray.
Results: One year after the initial assessment, 52.5% of the women had their
initial HPV infection resolved and 35% of the women had acquired another
HPV infection. The HPV DNA persistence was detected in 17.5% of the
40 women. Nine women had acquisition of HPV genotype by the same
phylogenetic clade. 43.33% of high risk (HR) HPV type and 80% of the low
risk (LR) HPV type infection had resolved.
Conclusions: The persistence rate was increased in women with HR HPV
types. Multiple and mixed HPV infections have an important impact on the
persistence of HPV genotype. (Marmara Medical Journal 2012;25:10-5)
Key Words: Cervical cytology, HPV genotype, HPV persistence, HPV clearance
Amaç: Marmara Üniversitesi Hastanesi kadın hastalıkları polikliniğinde human papilloma virüs (HPV) pozitif saptanan kadınlarda değişik HPV genotiplerinin persistansını değerlendirmek.

Hastalar ve Yöntem: İlk prevalans çalışmasında HPV DNA testi pozitif saptanan 79 kadından 40'ı bir yıl sonra tekrar değerlendirildi. HPV tipleri polymerase chain reaction (PCR) ve mikroarray hibridizasyon teknikleri ile tanımlandı.

Bulgular: İlk değerlendirmenin bir yıl sonrasında kadınların %52,5'nin HPV enfeksiyonunun ortadan kalktığı; %35 ‘inin yeni bir HPV enfeksiyonu edindiği saptandı. 40 kadının %17,5'inde HPV DNA persistansı saptandı. Dokuz kadın aynı filogenetik ağaçtan HPV genotipi edinmişti. Yüksek riskli (YR) HPV tipi enfeksiyonun %43,33'ü ve düşük riskli (DR) HPV tipi enfeksiyonun %80'i ortadan kalkmıştı.

Sonuç: Yüksek riskli HPV tipleri saptanan kadınlarda persistans oranı artmıştı. Çok sayıda ve karışık tipte HPV enfeksiyonları HPV genotipinin persistansında önemli etkiye sahiptir. (Marmara Üniversitesi Tıp Fakültesi Dergisi 2012;25:10-5)

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Primary Language en
Subjects Medicine
Journal Section Articles
Authors

Author: Tevfik YOLDEMİR

Author: Funda EREN

Author: Mithat ERENUS

Dates

Publication Date : February 25, 2015

Bibtex @research article { marumj2822, journal = {Marmara Medical Journal}, issn = {1019-1941}, eissn = {1309-9469}, address = {}, publisher = {Marmara University}, year = {2015}, volume = {25}, pages = {10 - 16}, doi = {}, title = {The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year}, key = {cite}, author = {Yoldemi̇r, Tevfik and Eren, Funda and Erenus, Mithat} }
APA Yoldemi̇r, T , Eren, F , Erenus, M . (2015). The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year . Marmara Medical Journal , 25 (1) , 10-16 . Retrieved from https://dergipark.org.tr/en/pub/marumj/issue/400/2822
MLA Yoldemi̇r, T , Eren, F , Erenus, M . "The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year" . Marmara Medical Journal 25 (2015 ): 10-16 <https://dergipark.org.tr/en/pub/marumj/issue/400/2822>
Chicago Yoldemi̇r, T , Eren, F , Erenus, M . "The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year". Marmara Medical Journal 25 (2015 ): 10-16
RIS TY - JOUR T1 - The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year AU - Tevfik Yoldemi̇r , Funda Eren , Mithat Erenus Y1 - 2015 PY - 2015 N1 - DO - T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 10 EP - 16 VL - 25 IS - 1 SN - 1019-1941-1309-9469 M3 - UR - Y2 - 2020 ER -
EndNote %0 Marmara Medical Journal The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year %A Tevfik Yoldemi̇r , Funda Eren , Mithat Erenus %T The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year %D 2015 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 25 %N 1 %R %U
ISNAD Yoldemi̇r, Tevfik , Eren, Funda , Erenus, Mithat . "The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year". Marmara Medical Journal 25 / 1 (February 2015): 10-16 .
AMA Yoldemi̇r T , Eren F , Erenus M . The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year. Marmara Med J. 2015; 25(1): 10-16.
Vancouver Yoldemi̇r T , Eren F , Erenus M . The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year. Marmara Medical Journal. 2015; 25(1): 10-16.
IEEE T. Yoldemi̇r , F. Eren and M. Erenus , "The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year", Marmara Medical Journal, vol. 25, no. 1, pp. 10-16, Feb. 2015