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Year 2012, Volume: 25 Issue: 2, 53 - 57, 17.03.2015

Abstract

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References

  • van Amerongen R, Nusse R. Towards an integrated view of Wnt
  • signaling in development. Development 2009; 136:3205-14.
  • doi:10.1242/dev.033910
  • Veeman MT, Axelrod JD, Moon RT. A second canon: functions and
  • mechanisms of β-catenin-independent Wnt signaling. Dev Cell 2003;
  • :367-77. doi: 10.1007/978-1-59745-249-6_10]
  • Kühl M, Sheldahl LC, Park M, et al. The Wnt/Ca2+ pathway: a new
  • vertebrate Wnt signaling pathway takes shape. Trends Genet 2000;
  • :279-83. doi:10.1016/S0168-9525(00)02028-X
  • Kikuchi A, Yamamoto H. Tumor formation due to abnormalities in the
  • beta-catenin-independent pathway of Wnt signalling. Cancer Sci
  • ; 99:202-8. doi: 10.1111/j.1349-7006.2007.00675.x
  • Lustig B, Behrens J. The Wnt signaling pathway and its role in tumor
  • development. J Cancer Res Clin Oncol 2003; 129: 199-21. doi:
  • 1007/s00432-003-0431-0
  • Donma MM, Donma O. Wnt signaling pathway in cardiovascular and
  • other clinical diseases: Review. Turkiye Klinikleri J Cardiovasc Sci
  • ;22:93-103.
  • Kaldis P, Pagano M. Wnt signaling in mitosis. Dev Cell 2009; 17:749-
  • doi: 10.1016/j.devcel.2009.12.001
  • Yamada S, Pokutta S, Drees F, et al. Deconstructing the cadherincatenin-actin
  • complex. Cell 2005; 123:889-901.
  • doi:10.1016/j.cell.2005.09.020
  • Klassen MP, Shen K. Wnt signaling positions neuromuscular
  • connectivity by inhibiting synapse formation in C. elegans. Cell 2007;
  • :704-16. doi: 10.1016/j.cell.2007.06.046
  • Takada I, Kouzmenko AP, Kato S. Wnt and PPARgamma signaling in
  • osteoblastogenesis and adipogenesis. Nat Rev Rheumatol 2009;
  • :442-7. doi:10.1038/nrrheum.2009.137
  • Hu J, Dong A, Fernandez-Ruiz V, et al. Blockade of Wnt signaling
  • inhibits angiogenesis and tumor growth in hepatocellular carcinoma.
  • Cancer Res 2009; 69:6951-9. doi:10.1158/0008-5472.CAN-09-0541
  • Nusse R, Varmus H. Wnt genes. Cell 1992; 69:1073-87.
  • Bradley RS, Brown AM. The proto-oncogene int-1 encodes a secreted
  • protein associated with the extracellular matrix. EMBO J 1990;
  • :1569-75.
  • Lorenowicz MJ, Korswagen HC. Sailing with the Wnt: charting the
  • Wnt processing and secretion route. Exp Cell Res 2009; 315:2683-9.
  • doi:10.1016/j.yexcr.2009.06.015
  • Tamai K, Semenov M, Kato Y, et al. LDL-receptor-related proteins in
  • Wnt signal transduction. Nature 2000; 407(6803):530-5.
  • doi:10.1038/35035117
  • Cadigan KM, Liu YI. Wnt signaling: complexity at the surface. J Cell
  • Sci 2006; 119(Pt 3):395-402.
  • Nusse R, Varmus HE. Many tumors induced by the mouse mammary
  • tumor virus contain a provirus integrated in the same region of the
  • host genome. Cell 1982; 31:99-109.
  • Nusse R, Brown A, Papkoff J, et al. A new nomenclature for int-l and
  • related genes: the Wnt gene family. Cell 1991; 64:231.
  • Adell T, Thakur AN, Müller WE. Isolation and characterization of Wnt
  • pathway-related genes from Porifera. Cell Biol Int 2007; 31:939-49.
  • Kusserow A, Pang K, Sturm C, et al. Unexpected complexity of the
  • Wnt gene family in a sea anemone. Nature 2005; 433(7022):156-60.
  • Li J, Nam KH. Regulation of brassinosteroid signaling by a
  • GSK3/SHAGGY-like kinase. Science 2002; 295(5558):1299-301.
  • Vert G, Nemhauser JL, Geldner N, et al. Molecular mechanisms of
  • steroid hormone signaling in plants. Annu Rev Cell Dev Biol 2005;
  • :177-201.
  • Miller JR. The Wnts. Genome Biol 2001;3:reviews3001.1-3001.15.
  • Kikuchi A, Yamamoto H, Kishida S. Multiplicity of the interactions of
  • Wnt proteins and their receptors. Cell Signal 2007; 19:659-71.
  • Willert K, Brown JD, Danenberg E, et al. Wnt proteins are lipidmodified
  • and can act as stem cell growth factors. Nature 2003;
  • (6938):448-52.
  • Niemann S, Zhao C, Pascu F, et al. Homozygous WNT3 mutation
  • causes tetra-amelia in a large consanguineous family. Am J Hum
  • Genet 2004; 74:558-63. doi:10.1086/382196
  • Peltoketo H, Allinen M, Vuosku J, et al. Characterization and
  • expression of the human WNT4; lack of associated germline
  • mutations in high--to moderate--risk breast and ovarian cancer.
  • Cancer Lett 2004; 213:83-90. doi:10.1016/j.canlet.2004.02.024
  • He B, You L, Uematsu K, et al. A monoclonal antibody against Wnt-
  • induces apoptosis in human cancer cells. Neoplasia 2004; 6:7-14.
  • You L, He B, Xu Z, et al. An anti-Wnt-2 monoclonal antibody induces
  • apoptosis in malignant melanoma cells and inhibits tumor growth.
  • Cancer Res 2004; 64:5385-9. doi:10.1158/0008-5472.CAN-04-1227
  • Wei W, Chua MS, Grepper S, et al. Blockade of Wnt-1 signaling leads
  • to anti-tumor effects in hepatocellular carcinoma cells. Mol Cancer
  • ; 8:76-86. doi:10.1186/1476-4598-8-76
  • Marmara Medical Journal 2012;25:53-7
  • Tanır ve ark. 56 Wnt/Beta-Katenin Hedef Hücre Zarı Biyomolekülleri
  • Bhanot P, Brink M, Samos CH, et al. A new member of the frizzled
  • family from Drosophila functions as a Wingless receptor. Nature
  • ; 382(6588):225-30. doi:10.1038/382225a0
  • Wang YK, Samos CH, Peoples R, et al. A novel human homologue of
  • the Drosophila frizzled wnt receptor gene binds wingless protein and
  • is in the Williams syndrome deletion at 7q11.23. Hum Mol Genet
  • ; 6:465-72.
  • Huang HC, Klein PS. The Frizzled family: receptors for multiple signal
  • transduction pathways. Genome Biol 2004; 5:234-41.
  • doi:10.1186/gb-2004-5-7-234
  • Wawrzak D, Luyten A, Lambaerts K, et al. Frizzled–PDZ scaffold
  • interactions in the control of Wnt signaling. Adv Enzyme Regul 2009;
  • :98-106.
  • Punchihewa C, Ferreira AM, Cassell R, et al. Sequence requirement and
  • subtype specificity in the high-affinity interaction between human
  • frizzled and dishevelled proteins. Protein Sci 2009; 18:994-1002.
  • doi:10.1002/pro.109
  • Umbhauer M, Djiane A, Goisset C, et al. The C-terminal cytoplasmic
  • Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/betacatenin
  • signalling. EMBO J 2000; 19:4944-54.
  • doi:10.1093/emboj/19.18.4944
  • Dann CE, Hsieh JC, Rattner A, et al. Insights into Wnt binding and
  • signalling from the structures of two Frizzled cysteine-rich domains.
  • Nature 2001; 412(6842):86-90. doi:10.1038/35083601
  • Povelones M, Nusse R. The role of the cysteine-rich domain of Frizzled
  • in Wingless-Armadillo signaling. EMBO J 2005; 24:3493-503.
  • doi:10.1038/sj.emboj.7600817
  • Kirikoshi H, Sekihara H, Katoh M. Expression profiles of 10 members
  • of Frizzled gene family in human gastric cancer. Int J Oncol 2001;
  • :767-71.
  • Nagayama S, Fukukawa C, Katagiri T, et al. Therapeutic potential of
  • antibodies against FZD 10, a cell-surface protein, for synovial
  • sarcomas. Oncogene 2005; 24:6201-12.
  • doi:10.1038/sj.onc.1208780
  • Wu QL, Zierold C, Ranheim EA. Dysregulation of Frizzled 6 is a critical
  • component of B-cell leukemogenesis in a mouse model of chronic
  • lymphocytic leukemia. Blood 2009; 113:3031-9.
  • doi:10.1182/blood-2008-6-163303
  • Fukukawa C, Hanaoka H, Nagayama S, et al. Radioimmunotherapy
  • of human synovial sarcoma using a monoclonal antibody against
  • FZD10. Cancer Sci 2008; 99:432-40.
  • He X, Semenov M, Tamai K, et al. LDL receptor-related proteins 5
  • and 6 in Wnt/b-catenin signaling: arrows point the way.
  • Development 2004; 131:1663-77.
  • Schweizer L, Varmus H. Wnt/Wingless signaling through beta-catenin
  • requires the function of both LRP/Arrow and frizzled classes of
  • receptors. BMC Cell Biol 2003; 4:4-15. doi:10.1186/1471-2121-4-4
  • MacDonald BT, Yokota C, Tamai K, et al. Wnt signal amplification via
  • activity, cooperativity, and regulation of multiple intracellular PPPSP
  • motifs in the Wnt co-receptor LRP6. J Biol Chem 2008; 283:16115-23.
  • doi.10.1074/jbc.M8003272200
  • Cuzzo LM, Ross-Cisneros FN, Yee KM, et al. Low-density lipoprotein
  • receptor-related protein is decreased in optic neuropathy of
  • Alzheimer disease. J Neuroophthalmol 2011;31:139-46.
  • doi:10.1097/WNO.0b013e31821b602c
  • Milat F, Ng KW. Is Wnt signalling the final common pathway leading
  • to bone formation? Mol Cell Endocrinol 2009; 310:52-62.
  • Ettenberg SA, Charlat O, Daley MP, et al. Inhibition of tumorigenesis
  • driven by different Wnt proteins requires blockade of distinct ligandbinding
  • regions by LRP6 antibodies. Proc Natl Acad Sci U S A 2010;
  • :15473-8. doi:10.1073/pnas.1007428107
  • Liu CC, Prior J, Piwnica-Worms D, et al. LRP6 overexpression defines
  • a class of breast cancer subtype and is a target for therapy. Proc Natl
  • Acad Sci USA 2010; 107:5136-41. doi:10.1073/pnas.0911220107
  • Guo Y, Rubin EM, Xie J, et al. Dominant negative LRP5 decreases
  • tumorigenicity and metastasis of osteosarcoma in an animal model.
  • Clin Orthop Relat Res 2008; 466:2039-45.
  • doi:10.1007/s11999-008-0344-y

Wnt/Beta-Katenin Sinyal Yolunda Görev Alan Hedef Hücre Zarı Biyomolekülleri

Year 2012, Volume: 25 Issue: 2, 53 - 57, 17.03.2015

Abstract

Wnt/β-katenin sinyal yolu hücre proliferasyonu ve farklılaşması, hücre siklusunun düzenlenmesi, hücre-hücre ve hücre-matriks etkileşimleri, anjiogenez, apoptozis ve adipogenez gibi çeşitli biyolojik olaylarda önemli rol oynar. Wnt/β-katenin sinyal yolu, Wnt proteininin hedef hücre zarındaki reseptörlerine bağlanmasıyla başlar ve bu bağlanma ile ekstraselüler bir sinyal, hücre zarından sitoplazmaya oradan da çekirdeğe kadar iletilir. Sinyal yolunun bu şekildeki aktivasyonu ile birçok genin transkripsiyonu da aktive edilmiş olur. Ancak Wnt, Fz ve LRP5/6 gibi proteinleri kodlayan genlerde meydana gelen mutasyonlar, hem Wnt/β-katenin sinyal yolunun kontrolsüz aktivasyonuna, hem de kanser başta olmak üzere birçok ciddi hastalıkların oluşmasına neden olabilmektedir. Dolayısıyla bu sinyal yolu ve bu yolda görev alan biyomoleküllerin aydınlatılması hem oluşumlarında rol oynadıkları hastalıkların etiyolojilerinin ayrıntılı biçimde ortaya konulmasında hem de bu hastalıkların tedavisi için yeni hedef moleküllerin belirlenmesinde oldukça önemlidir. Bu sebeple Wnt/β-katenin sinyalinin hedef hücre zarındaki başlangıç mekanizması ve bu mekanizmada görev yapan biyomoleküllerin tartışılması ve bu şekilde sinyal yolunun tam olarak aydınlatılması amaçlanmıştır. (Marmara Üniversitesi Tıp Fakültesi Dergisi 2012;25:53-7)

Anahtar Kelimeler: Wnt proteinleri, Beta-katenin, Fz, LRP5/6, Erişkin kök hücreler, Kanser

References

  • van Amerongen R, Nusse R. Towards an integrated view of Wnt
  • signaling in development. Development 2009; 136:3205-14.
  • doi:10.1242/dev.033910
  • Veeman MT, Axelrod JD, Moon RT. A second canon: functions and
  • mechanisms of β-catenin-independent Wnt signaling. Dev Cell 2003;
  • :367-77. doi: 10.1007/978-1-59745-249-6_10]
  • Kühl M, Sheldahl LC, Park M, et al. The Wnt/Ca2+ pathway: a new
  • vertebrate Wnt signaling pathway takes shape. Trends Genet 2000;
  • :279-83. doi:10.1016/S0168-9525(00)02028-X
  • Kikuchi A, Yamamoto H. Tumor formation due to abnormalities in the
  • beta-catenin-independent pathway of Wnt signalling. Cancer Sci
  • ; 99:202-8. doi: 10.1111/j.1349-7006.2007.00675.x
  • Lustig B, Behrens J. The Wnt signaling pathway and its role in tumor
  • development. J Cancer Res Clin Oncol 2003; 129: 199-21. doi:
  • 1007/s00432-003-0431-0
  • Donma MM, Donma O. Wnt signaling pathway in cardiovascular and
  • other clinical diseases: Review. Turkiye Klinikleri J Cardiovasc Sci
  • ;22:93-103.
  • Kaldis P, Pagano M. Wnt signaling in mitosis. Dev Cell 2009; 17:749-
  • doi: 10.1016/j.devcel.2009.12.001
  • Yamada S, Pokutta S, Drees F, et al. Deconstructing the cadherincatenin-actin
  • complex. Cell 2005; 123:889-901.
  • doi:10.1016/j.cell.2005.09.020
  • Klassen MP, Shen K. Wnt signaling positions neuromuscular
  • connectivity by inhibiting synapse formation in C. elegans. Cell 2007;
  • :704-16. doi: 10.1016/j.cell.2007.06.046
  • Takada I, Kouzmenko AP, Kato S. Wnt and PPARgamma signaling in
  • osteoblastogenesis and adipogenesis. Nat Rev Rheumatol 2009;
  • :442-7. doi:10.1038/nrrheum.2009.137
  • Hu J, Dong A, Fernandez-Ruiz V, et al. Blockade of Wnt signaling
  • inhibits angiogenesis and tumor growth in hepatocellular carcinoma.
  • Cancer Res 2009; 69:6951-9. doi:10.1158/0008-5472.CAN-09-0541
  • Nusse R, Varmus H. Wnt genes. Cell 1992; 69:1073-87.
  • Bradley RS, Brown AM. The proto-oncogene int-1 encodes a secreted
  • protein associated with the extracellular matrix. EMBO J 1990;
  • :1569-75.
  • Lorenowicz MJ, Korswagen HC. Sailing with the Wnt: charting the
  • Wnt processing and secretion route. Exp Cell Res 2009; 315:2683-9.
  • doi:10.1016/j.yexcr.2009.06.015
  • Tamai K, Semenov M, Kato Y, et al. LDL-receptor-related proteins in
  • Wnt signal transduction. Nature 2000; 407(6803):530-5.
  • doi:10.1038/35035117
  • Cadigan KM, Liu YI. Wnt signaling: complexity at the surface. J Cell
  • Sci 2006; 119(Pt 3):395-402.
  • Nusse R, Varmus HE. Many tumors induced by the mouse mammary
  • tumor virus contain a provirus integrated in the same region of the
  • host genome. Cell 1982; 31:99-109.
  • Nusse R, Brown A, Papkoff J, et al. A new nomenclature for int-l and
  • related genes: the Wnt gene family. Cell 1991; 64:231.
  • Adell T, Thakur AN, Müller WE. Isolation and characterization of Wnt
  • pathway-related genes from Porifera. Cell Biol Int 2007; 31:939-49.
  • Kusserow A, Pang K, Sturm C, et al. Unexpected complexity of the
  • Wnt gene family in a sea anemone. Nature 2005; 433(7022):156-60.
  • Li J, Nam KH. Regulation of brassinosteroid signaling by a
  • GSK3/SHAGGY-like kinase. Science 2002; 295(5558):1299-301.
  • Vert G, Nemhauser JL, Geldner N, et al. Molecular mechanisms of
  • steroid hormone signaling in plants. Annu Rev Cell Dev Biol 2005;
  • :177-201.
  • Miller JR. The Wnts. Genome Biol 2001;3:reviews3001.1-3001.15.
  • Kikuchi A, Yamamoto H, Kishida S. Multiplicity of the interactions of
  • Wnt proteins and their receptors. Cell Signal 2007; 19:659-71.
  • Willert K, Brown JD, Danenberg E, et al. Wnt proteins are lipidmodified
  • and can act as stem cell growth factors. Nature 2003;
  • (6938):448-52.
  • Niemann S, Zhao C, Pascu F, et al. Homozygous WNT3 mutation
  • causes tetra-amelia in a large consanguineous family. Am J Hum
  • Genet 2004; 74:558-63. doi:10.1086/382196
  • Peltoketo H, Allinen M, Vuosku J, et al. Characterization and
  • expression of the human WNT4; lack of associated germline
  • mutations in high--to moderate--risk breast and ovarian cancer.
  • Cancer Lett 2004; 213:83-90. doi:10.1016/j.canlet.2004.02.024
  • He B, You L, Uematsu K, et al. A monoclonal antibody against Wnt-
  • induces apoptosis in human cancer cells. Neoplasia 2004; 6:7-14.
  • You L, He B, Xu Z, et al. An anti-Wnt-2 monoclonal antibody induces
  • apoptosis in malignant melanoma cells and inhibits tumor growth.
  • Cancer Res 2004; 64:5385-9. doi:10.1158/0008-5472.CAN-04-1227
  • Wei W, Chua MS, Grepper S, et al. Blockade of Wnt-1 signaling leads
  • to anti-tumor effects in hepatocellular carcinoma cells. Mol Cancer
  • ; 8:76-86. doi:10.1186/1476-4598-8-76
  • Marmara Medical Journal 2012;25:53-7
  • Tanır ve ark. 56 Wnt/Beta-Katenin Hedef Hücre Zarı Biyomolekülleri
  • Bhanot P, Brink M, Samos CH, et al. A new member of the frizzled
  • family from Drosophila functions as a Wingless receptor. Nature
  • ; 382(6588):225-30. doi:10.1038/382225a0
  • Wang YK, Samos CH, Peoples R, et al. A novel human homologue of
  • the Drosophila frizzled wnt receptor gene binds wingless protein and
  • is in the Williams syndrome deletion at 7q11.23. Hum Mol Genet
  • ; 6:465-72.
  • Huang HC, Klein PS. The Frizzled family: receptors for multiple signal
  • transduction pathways. Genome Biol 2004; 5:234-41.
  • doi:10.1186/gb-2004-5-7-234
  • Wawrzak D, Luyten A, Lambaerts K, et al. Frizzled–PDZ scaffold
  • interactions in the control of Wnt signaling. Adv Enzyme Regul 2009;
  • :98-106.
  • Punchihewa C, Ferreira AM, Cassell R, et al. Sequence requirement and
  • subtype specificity in the high-affinity interaction between human
  • frizzled and dishevelled proteins. Protein Sci 2009; 18:994-1002.
  • doi:10.1002/pro.109
  • Umbhauer M, Djiane A, Goisset C, et al. The C-terminal cytoplasmic
  • Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/betacatenin
  • signalling. EMBO J 2000; 19:4944-54.
  • doi:10.1093/emboj/19.18.4944
  • Dann CE, Hsieh JC, Rattner A, et al. Insights into Wnt binding and
  • signalling from the structures of two Frizzled cysteine-rich domains.
  • Nature 2001; 412(6842):86-90. doi:10.1038/35083601
  • Povelones M, Nusse R. The role of the cysteine-rich domain of Frizzled
  • in Wingless-Armadillo signaling. EMBO J 2005; 24:3493-503.
  • doi:10.1038/sj.emboj.7600817
  • Kirikoshi H, Sekihara H, Katoh M. Expression profiles of 10 members
  • of Frizzled gene family in human gastric cancer. Int J Oncol 2001;
  • :767-71.
  • Nagayama S, Fukukawa C, Katagiri T, et al. Therapeutic potential of
  • antibodies against FZD 10, a cell-surface protein, for synovial
  • sarcomas. Oncogene 2005; 24:6201-12.
  • doi:10.1038/sj.onc.1208780
  • Wu QL, Zierold C, Ranheim EA. Dysregulation of Frizzled 6 is a critical
  • component of B-cell leukemogenesis in a mouse model of chronic
  • lymphocytic leukemia. Blood 2009; 113:3031-9.
  • doi:10.1182/blood-2008-6-163303
  • Fukukawa C, Hanaoka H, Nagayama S, et al. Radioimmunotherapy
  • of human synovial sarcoma using a monoclonal antibody against
  • FZD10. Cancer Sci 2008; 99:432-40.
  • He X, Semenov M, Tamai K, et al. LDL receptor-related proteins 5
  • and 6 in Wnt/b-catenin signaling: arrows point the way.
  • Development 2004; 131:1663-77.
  • Schweizer L, Varmus H. Wnt/Wingless signaling through beta-catenin
  • requires the function of both LRP/Arrow and frizzled classes of
  • receptors. BMC Cell Biol 2003; 4:4-15. doi:10.1186/1471-2121-4-4
  • MacDonald BT, Yokota C, Tamai K, et al. Wnt signal amplification via
  • activity, cooperativity, and regulation of multiple intracellular PPPSP
  • motifs in the Wnt co-receptor LRP6. J Biol Chem 2008; 283:16115-23.
  • doi.10.1074/jbc.M8003272200
  • Cuzzo LM, Ross-Cisneros FN, Yee KM, et al. Low-density lipoprotein
  • receptor-related protein is decreased in optic neuropathy of
  • Alzheimer disease. J Neuroophthalmol 2011;31:139-46.
  • doi:10.1097/WNO.0b013e31821b602c
  • Milat F, Ng KW. Is Wnt signalling the final common pathway leading
  • to bone formation? Mol Cell Endocrinol 2009; 310:52-62.
  • Ettenberg SA, Charlat O, Daley MP, et al. Inhibition of tumorigenesis
  • driven by different Wnt proteins requires blockade of distinct ligandbinding
  • regions by LRP6 antibodies. Proc Natl Acad Sci U S A 2010;
  • :15473-8. doi:10.1073/pnas.1007428107
  • Liu CC, Prior J, Piwnica-Worms D, et al. LRP6 overexpression defines
  • a class of breast cancer subtype and is a target for therapy. Proc Natl
  • Acad Sci USA 2010; 107:5136-41. doi:10.1073/pnas.0911220107
  • Guo Y, Rubin EM, Xie J, et al. Dominant negative LRP5 decreases
  • tumorigenicity and metastasis of osteosarcoma in an animal model.
  • Clin Orthop Relat Res 2008; 466:2039-45.
  • doi:10.1007/s11999-008-0344-y
There are 149 citations in total.

Details

Primary Language Turkish
Journal Section Review Makaleler
Authors

Hanife Tanır This is me

Şayeste Demirezen

Mehmet Beksaç This is me

Publication Date March 17, 2015
Published in Issue Year 2012 Volume: 25 Issue: 2

Cite

APA Tanır, H., Demirezen, Ş., & Beksaç, M. (2015). Wnt/Beta-Katenin Sinyal Yolunda Görev Alan Hedef Hücre Zarı Biyomolekülleri. Marmara Medical Journal, 25(2), 53-57.
AMA Tanır H, Demirezen Ş, Beksaç M. Wnt/Beta-Katenin Sinyal Yolunda Görev Alan Hedef Hücre Zarı Biyomolekülleri. Marmara Med J. August 2015;25(2):53-57.
Chicago Tanır, Hanife, Şayeste Demirezen, and Mehmet Beksaç. “Wnt/Beta-Katenin Sinyal Yolunda Görev Alan Hedef Hücre Zarı Biyomolekülleri”. Marmara Medical Journal 25, no. 2 (August 2015): 53-57.
EndNote Tanır H, Demirezen Ş, Beksaç M (August 1, 2015) Wnt/Beta-Katenin Sinyal Yolunda Görev Alan Hedef Hücre Zarı Biyomolekülleri. Marmara Medical Journal 25 2 53–57.
IEEE H. Tanır, Ş. Demirezen, and M. Beksaç, “Wnt/Beta-Katenin Sinyal Yolunda Görev Alan Hedef Hücre Zarı Biyomolekülleri”, Marmara Med J, vol. 25, no. 2, pp. 53–57, 2015.
ISNAD Tanır, Hanife et al. “Wnt/Beta-Katenin Sinyal Yolunda Görev Alan Hedef Hücre Zarı Biyomolekülleri”. Marmara Medical Journal 25/2 (August 2015), 53-57.
JAMA Tanır H, Demirezen Ş, Beksaç M. Wnt/Beta-Katenin Sinyal Yolunda Görev Alan Hedef Hücre Zarı Biyomolekülleri. Marmara Med J. 2015;25:53–57.
MLA Tanır, Hanife et al. “Wnt/Beta-Katenin Sinyal Yolunda Görev Alan Hedef Hücre Zarı Biyomolekülleri”. Marmara Medical Journal, vol. 25, no. 2, 2015, pp. 53-57.
Vancouver Tanır H, Demirezen Ş, Beksaç M. Wnt/Beta-Katenin Sinyal Yolunda Görev Alan Hedef Hücre Zarı Biyomolekülleri. Marmara Med J. 2015;25(2):53-7.