Paraoksonaz-1 Enzimi ve Koroner Kalp Hastalıkları ile İlişkisi

Year 2011, Volume: 24 Issue: 1, 59 - 63, 21.04.2015

Özlem Tarçın

Abstract

Anti-oksidan bir enzim olan paraoksonaz-1(PON1) enzim düzeyi ve aktivitesi, koroner arter hastalığı ile ilişkili olan hipertansiyon, diyabet, hiperlipidemi ve sigara kullanımı ile azalmaktadır. Tüm çalışmalar anjiografik olarak koroner arter hastalığı(KAH) kanıtlanmış olan hastalarda PON1 düzeyinin düştüğünü göstermektedir. Ancak polimorfizm açısından net olarak tek bir polimorfizm ile ilişkisi gösterilememiştir. Bu bilgilerin ışığında PON1 enzim düzeyi, KAH gelişimi açısından belirleyici bir marker olabilir. Ancak bunun klinik olarak kanıtlanması için prospektif ve kontrollü çalışmalara ihtiyaç vardır.

Anahtar Kelimeler: Paraoksonaz-1, Koroner kalp hastalıkları, PON1 polimorfizm

Keywords

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