Technological advances in radiation therapy delivery have permitted the use of high dose per fraction radiotherapy for early stage prostate cancer. Level I evidence supporting the safety and efficasy of hypofractionated radiotherapy is evolving. Moderate and extreme hypofractionation regimens show promising cancer control but long term results of noninferiority studies of both modalities are required before use in routine treatment as standard of care. Keywords: Prostate cancer, Curative radiotherapy, Moderate and extreme hypo fractionation
1. Dearnaley D, Syndikus I, Sumo G, et al. Conventional versus hypofractionated high dose intensity modulated radiotherapy for prostate cancer: preliminary safety results from the CHHiP randomised control trial. Lancet Oncol 2012;13:43-54. doi: 10.1016/S1470- 2045(11)70293-5.
2. Arcangeli G, Saracino B, Gomellini S, et al. A prospective phase III randomised trial of hypofractination versus conventional fractionation in patients with high risk prostate cancer. Int J Radiat Oncol Biol Phys 2008;72:11-18. doi: 10.1016/j.ijrobp.2009.07.1691.
3. Arcangeli G, Strigari L, Gomellini S, et al. Updated results and patterns of failure in a randomized hypofractionation trial for high risk prostate cancer. Int J Radiat Oncol Biol Phys 2012;84:1172-8. doi: 10.1016/j. ijrobp.2012.02.049.
4. Pollack A, Hanlon AL, Horwitz EM, et al. Dosimetry and preliminary acute toxicity in the first 100 men treated for prostate cancer on a randomized hypofractionation dose escalation trial. Int J Radiat Oncol Biol Phys 2006;64:518-26.
5. Pollack A, Walker G, Buyyounouski M, et al. Five year results of a randomized external beam radiotherapy hypofractionation trial for prostate cancer. Int J Radiat Oncol Biol Phys 2011;81(Suppl. 2):S1
6. Kuban D, N.-G. GM, Hamblin L, et al. Preliminary report of a randomized dose escalation trial for prostate cancer using hypofractionation. Int J Radiat Oncol Biol Phys 2010;78(Suppl. 3):S58-S59.
7. Katz A, Kang J. Stereotactic body radiation therapy for low, intermediate and high risk prostate cancer: disease control and quality of life at 6 years. Int J Radiat Oncol Biol Phys 2013;87:524-5.
8. Loblaw A, Cheung P, D’Alimonte L, et al. Prostate stereotactic ablative body radiotherapy using a standard linear accelerator: toxicity, biochemical, and pathological outcomes. Radiother Oncol 2013;107:153- 8. doi: 10.1016/j.radonc.2013.03.022.
9. Alicikus ZA, Yamada Y, Zhang Z, et al. Ten year outcomes of high dose intensity modulated radiotherapy for localized prostate cancer. Cancer 2011;117:1429- 37. doi: 10.1002/cncr.25467.
10. Chen LN, Suy S, Wang H, et al. Patient reported urinary incontinence following stereotactic body radiation therapy for clinically localized prostate cancer. Radiat Oncol 2014;9:148. doi: 10.1186/1748-717X-9-148.
Year 2015,
Special Issue :1 Oncology, 21 - 23, 30.09.2015
1. Dearnaley D, Syndikus I, Sumo G, et al. Conventional versus hypofractionated high dose intensity modulated radiotherapy for prostate cancer: preliminary safety results from the CHHiP randomised control trial. Lancet Oncol 2012;13:43-54. doi: 10.1016/S1470- 2045(11)70293-5.
2. Arcangeli G, Saracino B, Gomellini S, et al. A prospective phase III randomised trial of hypofractination versus conventional fractionation in patients with high risk prostate cancer. Int J Radiat Oncol Biol Phys 2008;72:11-18. doi: 10.1016/j.ijrobp.2009.07.1691.
3. Arcangeli G, Strigari L, Gomellini S, et al. Updated results and patterns of failure in a randomized hypofractionation trial for high risk prostate cancer. Int J Radiat Oncol Biol Phys 2012;84:1172-8. doi: 10.1016/j. ijrobp.2012.02.049.
4. Pollack A, Hanlon AL, Horwitz EM, et al. Dosimetry and preliminary acute toxicity in the first 100 men treated for prostate cancer on a randomized hypofractionation dose escalation trial. Int J Radiat Oncol Biol Phys 2006;64:518-26.
5. Pollack A, Walker G, Buyyounouski M, et al. Five year results of a randomized external beam radiotherapy hypofractionation trial for prostate cancer. Int J Radiat Oncol Biol Phys 2011;81(Suppl. 2):S1
6. Kuban D, N.-G. GM, Hamblin L, et al. Preliminary report of a randomized dose escalation trial for prostate cancer using hypofractionation. Int J Radiat Oncol Biol Phys 2010;78(Suppl. 3):S58-S59.
7. Katz A, Kang J. Stereotactic body radiation therapy for low, intermediate and high risk prostate cancer: disease control and quality of life at 6 years. Int J Radiat Oncol Biol Phys 2013;87:524-5.
8. Loblaw A, Cheung P, D’Alimonte L, et al. Prostate stereotactic ablative body radiotherapy using a standard linear accelerator: toxicity, biochemical, and pathological outcomes. Radiother Oncol 2013;107:153- 8. doi: 10.1016/j.radonc.2013.03.022.
9. Alicikus ZA, Yamada Y, Zhang Z, et al. Ten year outcomes of high dose intensity modulated radiotherapy for localized prostate cancer. Cancer 2011;117:1429- 37. doi: 10.1002/cncr.25467.
10. Chen LN, Suy S, Wang H, et al. Patient reported urinary incontinence following stereotactic body radiation therapy for clinically localized prostate cancer. Radiat Oncol 2014;9:148. doi: 10.1186/1748-717X-9-148.
Igdem, S. (2015). Treatment of prostate cancer by hypofractionated radiotherapy. Marmara Medical Journal, 28(1), 21-23. https://doi.org/10.5472/mmj.11680
AMA
Igdem S. Treatment of prostate cancer by hypofractionated radiotherapy. Marmara Med J. September 2015;28(1):21-23. doi:10.5472/mmj.11680
Chicago
Igdem, Sefik. “Treatment of Prostate Cancer by Hypofractionated Radiotherapy”. Marmara Medical Journal 28, no. 1 (September 2015): 21-23. https://doi.org/10.5472/mmj.11680.
EndNote
Igdem S (September 1, 2015) Treatment of prostate cancer by hypofractionated radiotherapy. Marmara Medical Journal 28 1 21–23.
IEEE
S. Igdem, “Treatment of prostate cancer by hypofractionated radiotherapy”, Marmara Med J, vol. 28, no. 1, pp. 21–23, 2015, doi: 10.5472/mmj.11680.
ISNAD
Igdem, Sefik. “Treatment of Prostate Cancer by Hypofractionated Radiotherapy”. Marmara Medical Journal 28/1 (September 2015), 21-23. https://doi.org/10.5472/mmj.11680.
JAMA
Igdem S. Treatment of prostate cancer by hypofractionated radiotherapy. Marmara Med J. 2015;28:21–23.
MLA
Igdem, Sefik. “Treatment of Prostate Cancer by Hypofractionated Radiotherapy”. Marmara Medical Journal, vol. 28, no. 1, 2015, pp. 21-23, doi:10.5472/mmj.11680.
Vancouver
Igdem S. Treatment of prostate cancer by hypofractionated radiotherapy. Marmara Med J. 2015;28(1):21-3.