Year 2015, Volume 28 , Issue 1, Pages 35 - 39 2015-09-30

CDK inhibitors in hormone receptor positive advanced breast cancer

Bilge AKTAS [1]

Endocrine treatment is the current first line treatment in ER+
advanced breast cancer with a requirement of predictive
biomarkers to the treatment and different approaches for
endocrine resistance risk. Cyclin dependent kinases (CDKs)
are regulating each step of cellular division in mammalian
cell cycle and are hyperactivated in cancer cells causing
cancer progression. Next generation pan-CDK inhibitors are
in clinical development, while clinical trials in breast cancer,
particularly in ER+ subtype where the greatest growth
inhibition has been observed. Here I will review the data
from this new class of drugs.
Keywords: CDK inhibitors, Hormone positive advanced
breast cancer, Targeted therapies, Palbociclib, Endocrine
therapy resistance

CDK inhibitors, Hormone positive advanced breast cancer, Targeted therapies, Palbociclib, Endocrine therapy resistance
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Primary Language en
Journal Section Articles

Author: Bilge AKTAS


Publication Date : September 30, 2015

Bibtex @ { marumj2881, journal = {Marmara Medical Journal}, issn = {1019-1941}, eissn = {1309-9469}, address = {}, publisher = {Marmara University}, year = {2015}, volume = {28}, pages = {35 - 39}, doi = {10.5472/mmj.77406}, title = {CDK inhibitors in hormone receptor positive advanced breast cancer}, key = {cite}, author = {Aktas, Bilge} }
APA Aktas, B . (2015). CDK inhibitors in hormone receptor positive advanced breast cancer . Marmara Medical Journal , Special Issue :1 Oncology , 35-39 . DOI: 10.5472/mmj.77406
MLA Aktas, B . "CDK inhibitors in hormone receptor positive advanced breast cancer" . Marmara Medical Journal 28 (2015 ): 35-39 <>
Chicago Aktas, B . "CDK inhibitors in hormone receptor positive advanced breast cancer". Marmara Medical Journal 28 (2015 ): 35-39
RIS TY - JOUR T1 - CDK inhibitors in hormone receptor positive advanced breast cancer AU - Bilge Aktas Y1 - 2015 PY - 2015 N1 - doi: 10.5472/mmj.77406 DO - 10.5472/mmj.77406 T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 35 EP - 39 VL - 28 IS - 1 SN - 1019-1941-1309-9469 M3 - doi: 10.5472/mmj.77406 UR - Y2 - 2021 ER -
EndNote %0 Marmara Medical Journal CDK inhibitors in hormone receptor positive advanced breast cancer %A Bilge Aktas %T CDK inhibitors in hormone receptor positive advanced breast cancer %D 2015 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 28 %N 1 %R doi: 10.5472/mmj.77406 %U 10.5472/mmj.77406
ISNAD Aktas, Bilge . "CDK inhibitors in hormone receptor positive advanced breast cancer". Marmara Medical Journal 28 / 1 (September 2015): 35-39 .
AMA Aktas B . CDK inhibitors in hormone receptor positive advanced breast cancer. Marmara Med J. 2015; 28(1): 35-39.
Vancouver Aktas B . CDK inhibitors in hormone receptor positive advanced breast cancer. Marmara Medical Journal. 2015; 28(1): 35-39.
IEEE B. Aktas , "CDK inhibitors in hormone receptor positive advanced breast cancer", Marmara Medical Journal, vol. 28, no. 1, pp. 35-39, Sep. 2015, doi:10.5472/mmj.77406