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Year 2010, Volume: 23 Issue: 2, 2010 - 322, 27.04.2015

Esma Sarıkaya , Tayfun Güngör Gülnur Özakşit Leyla Mollamahmutoğlu

Abstract

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Keywords

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References

  • 1. Brinkmann AO, Jenster G, Kuiper GG, J.M. et al. The human androgen receptor: structure/function relationship in normal and pathological situations. J Steroid Biochem Mol Biol 1992; 41: 361–368.
  • 2. Brown CJ, Goss S J, Lubahn DB. et al. Androgen receptor locus on human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism. Am J Hum Genet 1989; 44: 264–269.
  • 3. Chang C, Kokontis J, Liao S. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science, 1988; 240: 324–326.
  • 4. Lubahn DB, Joseph DR, Sullivan PM, et al. Cloning of human androgen receptor complementary DNA and localization to the X-chromosome. Science 1988: 240: 327–330.
  • 5. Trampan J, Klaassen P, Kuiper GGJM, et al. Cloning, structure and expression of a cDNA encoding the human androgen receptor. Biochem Biophys Res Comm 1988; 153:241–248.
  • 6. Tilley W D, Marcelli M, Wilson J D, McPhaul MJ. Characterization and expression of a cDNA encoding the human androgen receptor. Proc Natl Acad Sci USA, 1989; 86: 327–331.
  • 7. Wiener JS, TeagueJL, Roth DR, et al. Molecular biology and function of the androgen receptor in genital development. J Urol 1997;157: 1377-138.
  • 8. Hiort O, Sinnecker G H G, Holterhus P M, et al. The clinical and molecular spectrum of androgen insensitivity syndrome. Am J Med Genet 1996; 63:218–222.
  • 9. McKusick VA. Androgen receptor. In: McKusick VA, ed. Mendelian Inheritance in Man. 12th edition. Baltimore: Johns Hopkins University Press, 1998:313700.
  • 10. Patterson MN, Hughes IA, Gottlieb B, Pinsky L. The androgen receptor gene mutations database. Nucleic Acids Res 1994; 22: 3560–3562.
  • 11. Simpson JL. Disorders of the gonads, genital tract and genitalia. In: Rimoin DL, Connor JM, Pyeritz RE, eds. Emery and Rimoin's Principles and Practice of Medical Genetics. 3rd edition. Churchill Livingstone, 1997:1477–1500.
  • 12. Yong EL, Tut TG, Ghadessy FJ, Prins G, Ratnam SS. Partial androgen insensitivity and correlations with the predicted three dimensional structure of the androgen receptor ligand-binding domain. Mol Cell Endocrinol 1998; 137: 41-50.
  • 13. Verp M, Simpson J. Abnormal sexual differantiation and neoplasia. Cancer Genet Cytogenet 1987; 25: 191-218.
  • 14. Sakai N, Yamada T, Baba M, et al. Bilateral testicular tumors in androgen insensitivity syndrome Int J Urol 2000; 7: 390-392.
  • 15. Antonini S, Barbosa AS, Rosenberg C, et al. RB1 deletion in gonadoblastoma in an XY female. Hum Genet 1997; 101: 181–185.
  • 16. Wenstrom KD. Fragile X and other trinucleotide repeat diseases. 2002;29:367-88.
  • 17. Ferro P, Catalano MG, Dell'Eva R, Fortunati N, Pfeffer U. The androgen receptor CAG repeat: a modifier of carcinogenesis? 2002;193:109-120.
  • 18. Sasaki M, Sakuragi N, Dahiya R. The CAG repeats in exon 1 of the androgen receptor gene are significantly longer in endometrial cancer patients. Biochem Biophys Res Commun. 2003 13;305:1105-1108.
  • 19. Dietzsch E, Laubscher R, Parker MI. Esophageal cancer risk in relation to GGC and CAG trinucleotide repeat lengths in the androgen receptor gene. Int J Cancer 2003;107:38-45.
  • 20. Eldar-Geva T, Milatiner D, Halle D. Androgen receptor and male infertility. Harefuah 2004;143:432- 461.
  • 21. Sasaki M, Karube A, Karube Y, et al. GGC and StuI polymorphism on the androgen receptor gene in endometrial cancer patients.Biochem Biophys Res Commun 2005;329:100-104.
  • 22. Ghadessy FJ, Lim J, Abdullah AA, et al. Oligospermic infertility associated with an androgen receptor mutation that disrupts interdomain and coactivator (TIF2) interactions. J Clin Invest 1999; 103: 1517-1525.
  • 23. Yong EL, Lim LS, Wang Q, et al. Androgen receptor polymorphisms and mutations in male infertility. J Endocrinol Invest 2000; 23: 573-577.
  • 24. La Spada AR, Wilson EM, Lubahn DB, et al. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 1991; 352: 77– 79.
  • 25. Sobue G. Triplet repeat disease, with particular emphasis of spinal and bulbar muscular atrophy (SBMA) Rinsho Shinkeigaku 2000;40:1193-1195.
  • 26. Cram DS, Song B, McLachlan RI, Trounson AO. CAG trinucleotide repeats in the androgen receptor gene of infertile men exhibit stable inheritance in female offspring conceived after ICSI. Mol Hum Reprod 2000;6:861-866.
  • 27. Kung HJ, Evans CP. Oncogenic activation of androgen receptor. Urol Oncol 2009;27:48-52.
  • 28. Niu Y, Yeh S, Miyamoto H, Li G, et al.Tissue prostatespecific antigen facilitates refractory prostate tumor progression via enhancing ARA70-regulated androgen receptor transactivation.Cancer Res 2008;68(17):7110-7119.
  • 29. Yeh S, Sampson ER, Lee DK, et al. Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer. J Formos Med Assoc 2000;99: 885-894.
  • 30. Gutiérrez-Enríquez S, Ramón y Cajal T. Breast cancer susceptibility genes. Med Clin (Barc).2006;126:304- 310.
  • 31. Elhaji YA, Gottlieb B, Lumbroso R, et al. The polymorphic CAG repeat of the androgen receptor gene: a potential role in breast cancer in women over 40. Breast Cancer Res Treat 2001;70:109-116.
  • 32. Di Fabio F, Alvarado C, Gologan A, et al. Somatic mosaicism of androgen receptor CAG repeats in colorectal carcinoma epithelial cells from men. J Surg Res 2009; 154 (1):38-44.
  • 33. Yu MW, Cheng SW, Lin MW, et al. Androgenreceptor gene CAG repeats, plasma testosterone levels, and risk of hepatitis B-related hepatocellular carcinoma. J Natl Cancer Inst. 2000 20;92: 2023- 2028.
  • 34. Awan AK, Iftikhar SY, Morris TM, et al. Androgen receptors may act in a paracrine manner to regulate oesophageal adenocarcinoma growth. Eur J Surg Oncol.2007;33: 561-568.
  • 35. Tihan T, Harmon JW, Wan X. Evidence of androgen receptor expression in squamous and adenocarcinoma of the esophagus. Anticancer Res. 2001;21:3107- 3114.
  • 36. Ito K, Suzuki T, Akahira J, et al. Expression of androgen receptor and 5alpha-reductases in the human normal endometrium and its disorders. Int J Cancer. 2002;99: 652-657.
  • 37. Rodríguez G, Bilbao C, Ramírez R, et al. Alleles with short CAG and GGN repeats in the androgen receptor gene are associated with benign endometrial cancer. Int J Cancer. 2006;118:1420-1425.
  • 38. Li AJ, Elmore RG, Pavelka JC, Karlan BY. Hyperandrogenism, mediated by obesity and receptor polymorphisms, promotes aggressive epithelial ovarian cancer biology. Gynecol Oncol. 2007;107:420-423.
  • 39. Li AJ, Scoles DR, Armstrong KU, Karlan BY. Androgen receptor cytosine-adenine-guanine repeat polymorphisms modulate EGFR signaling in epithelial ovarian carcinomas. Gynecol Oncol. 2008;109:220-225.
  • 40. Levine DA, Boyd J. The androgen receptor and genetic susceptibility to ovarian cancer: results from a case series. Cancer Res. 2001 1;61: 908-911.
  • 41. dos Santos ML, Sibov TT, Nishimoto IN, Kowalski LP, Miracca EC, Nagai MA. The CAG repeat polymorphism in the androgen receptor gene (AR) and its relationship to head and neck cancer. Oral Oncol. 2004;40:177-182.
  • 42. Chen YS, Hua KQ. Expression of androgen receptor in the vaginal wall and cardinal ligament of patients with pelvic organ prolapse. Zhonghua Yi Xue Za Zhi. 2008;88: 2920-2923.
  • 43. Langdahl BL, Stenkjaer L, Carstens M, Tofteng CL, Eriksen EF. A CAG repeat polymorphism in the androgen receptor gene is associated with reduced bone mass and increased risk of osteoporotic fractures. Calcif Tissue Int. 2003;73:237-243.
  • 44. Stanworth RD, Kapoor D, Channer KS, Jones TH. Androgen receptor CAG repeat polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes. Eur J Endocrinol 2008 159: 739-746.
  • 45. Mifsud A, Ramirez S, Yong EL. Androgen receptor gene CAG trinucleotide repeats in anovulatory infertility and polycystic ovaries. J Clin Endocrinol Metab. 2000;85: 3484-3488.
  • 46. Kim JJ, Choung SH, Choi YM, Yoon SH, Kim SH, Moon SY. Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome. Fertil Steril. 2008;90: 2318-2323.
  • 47. Jakubowski L. Genetic aspects of polycystic ovary syndrome. Endokrynol Pol. 2005;56: 285-293.
  • 48. Sawaya ME, Shalita AR. Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne. J Cutan Med Surg. 1998;3: 9-15.
  • 49. Hersberger M, Muntwyler J, Funke H, et al. The CAG repeat polymorphism in the androgen receptor gene is associated with HDL-cholesterol but not with coronary atherosclerosis or myocardial infarction. Clin Chem. 2005;51:1110-1115.
  • 50. Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care. 2009;12:232-240.

ANDROJEN RESEPTÖR GENİ VE JİNEKOLOJİ, İNFERTİLİTE VE ONKOLOJİ İÇİN KLİNİK ÖNEMİ

Year 2010, Volume: 23 Issue: 2, 2010 - 322, 27.04.2015

Esma Sarıkaya , Tayfun Güngör Gülnur Özakşit Leyla Mollamahmutoğlu

Abstract

Bu derlemede androjen reseptör geni ve jinekoloji, onkoloji ve infertilite için klinik önemi araştırılmıştır. “Androjen reseptör” kelimesi girilerek Medline ve PubMED de yer alan ve 1990 ve 2009 yıllarını kapsayan literatürler gözden geçirilmiştir. Androjen reseptörü, spermatogenezi ve erkek seksüel fenotiplerini belirleyen androjen etkisini regüle eder. Androjen reseptöründeki konstitüsyonel mutasyonlar çeşitli formlardaki erkek psödohermafroditizmine yol açar. AR CAG tekrar uzunluğundaki varyasyonlar bazı kanserler, pelvik organ prolapsusu, osteoporoz, polikistik hastalarda görülen hiperandrojenemi, metabolik sendrom ve erkek infertilitesi ile ilişkilendirilmiştir. Reprodüktif tıp, jinekoloji ve onkolojinin klinik pratiğinde genetik araştırmalar, standart bir gereksinim olmaya başlamıştır.

Anahtar Kelimeler: AR proteini, Infertilite, Jinekoloji, Neoplaziler

Keywords

AR proteini Infertilite Jinekoloji Neoplaziler

References

  • 1. Brinkmann AO, Jenster G, Kuiper GG, J.M. et al. The human androgen receptor: structure/function relationship in normal and pathological situations. J Steroid Biochem Mol Biol 1992; 41: 361–368.
  • 2. Brown CJ, Goss S J, Lubahn DB. et al. Androgen receptor locus on human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism. Am J Hum Genet 1989; 44: 264–269.
  • 3. Chang C, Kokontis J, Liao S. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science, 1988; 240: 324–326.
  • 4. Lubahn DB, Joseph DR, Sullivan PM, et al. Cloning of human androgen receptor complementary DNA and localization to the X-chromosome. Science 1988: 240: 327–330.
  • 5. Trampan J, Klaassen P, Kuiper GGJM, et al. Cloning, structure and expression of a cDNA encoding the human androgen receptor. Biochem Biophys Res Comm 1988; 153:241–248.
  • 6. Tilley W D, Marcelli M, Wilson J D, McPhaul MJ. Characterization and expression of a cDNA encoding the human androgen receptor. Proc Natl Acad Sci USA, 1989; 86: 327–331.
  • 7. Wiener JS, TeagueJL, Roth DR, et al. Molecular biology and function of the androgen receptor in genital development. J Urol 1997;157: 1377-138.
  • 8. Hiort O, Sinnecker G H G, Holterhus P M, et al. The clinical and molecular spectrum of androgen insensitivity syndrome. Am J Med Genet 1996; 63:218–222.
  • 9. McKusick VA. Androgen receptor. In: McKusick VA, ed. Mendelian Inheritance in Man. 12th edition. Baltimore: Johns Hopkins University Press, 1998:313700.
  • 10. Patterson MN, Hughes IA, Gottlieb B, Pinsky L. The androgen receptor gene mutations database. Nucleic Acids Res 1994; 22: 3560–3562.
  • 11. Simpson JL. Disorders of the gonads, genital tract and genitalia. In: Rimoin DL, Connor JM, Pyeritz RE, eds. Emery and Rimoin's Principles and Practice of Medical Genetics. 3rd edition. Churchill Livingstone, 1997:1477–1500.
  • 12. Yong EL, Tut TG, Ghadessy FJ, Prins G, Ratnam SS. Partial androgen insensitivity and correlations with the predicted three dimensional structure of the androgen receptor ligand-binding domain. Mol Cell Endocrinol 1998; 137: 41-50.
  • 13. Verp M, Simpson J. Abnormal sexual differantiation and neoplasia. Cancer Genet Cytogenet 1987; 25: 191-218.
  • 14. Sakai N, Yamada T, Baba M, et al. Bilateral testicular tumors in androgen insensitivity syndrome Int J Urol 2000; 7: 390-392.
  • 15. Antonini S, Barbosa AS, Rosenberg C, et al. RB1 deletion in gonadoblastoma in an XY female. Hum Genet 1997; 101: 181–185.
  • 16. Wenstrom KD. Fragile X and other trinucleotide repeat diseases. 2002;29:367-88.
  • 17. Ferro P, Catalano MG, Dell'Eva R, Fortunati N, Pfeffer U. The androgen receptor CAG repeat: a modifier of carcinogenesis? 2002;193:109-120.
  • 18. Sasaki M, Sakuragi N, Dahiya R. The CAG repeats in exon 1 of the androgen receptor gene are significantly longer in endometrial cancer patients. Biochem Biophys Res Commun. 2003 13;305:1105-1108.
  • 19. Dietzsch E, Laubscher R, Parker MI. Esophageal cancer risk in relation to GGC and CAG trinucleotide repeat lengths in the androgen receptor gene. Int J Cancer 2003;107:38-45.
  • 20. Eldar-Geva T, Milatiner D, Halle D. Androgen receptor and male infertility. Harefuah 2004;143:432- 461.
  • 21. Sasaki M, Karube A, Karube Y, et al. GGC and StuI polymorphism on the androgen receptor gene in endometrial cancer patients.Biochem Biophys Res Commun 2005;329:100-104.
  • 22. Ghadessy FJ, Lim J, Abdullah AA, et al. Oligospermic infertility associated with an androgen receptor mutation that disrupts interdomain and coactivator (TIF2) interactions. J Clin Invest 1999; 103: 1517-1525.
  • 23. Yong EL, Lim LS, Wang Q, et al. Androgen receptor polymorphisms and mutations in male infertility. J Endocrinol Invest 2000; 23: 573-577.
  • 24. La Spada AR, Wilson EM, Lubahn DB, et al. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 1991; 352: 77– 79.
  • 25. Sobue G. Triplet repeat disease, with particular emphasis of spinal and bulbar muscular atrophy (SBMA) Rinsho Shinkeigaku 2000;40:1193-1195.
  • 26. Cram DS, Song B, McLachlan RI, Trounson AO. CAG trinucleotide repeats in the androgen receptor gene of infertile men exhibit stable inheritance in female offspring conceived after ICSI. Mol Hum Reprod 2000;6:861-866.
  • 27. Kung HJ, Evans CP. Oncogenic activation of androgen receptor. Urol Oncol 2009;27:48-52.
  • 28. Niu Y, Yeh S, Miyamoto H, Li G, et al.Tissue prostatespecific antigen facilitates refractory prostate tumor progression via enhancing ARA70-regulated androgen receptor transactivation.Cancer Res 2008;68(17):7110-7119.
  • 29. Yeh S, Sampson ER, Lee DK, et al. Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer. J Formos Med Assoc 2000;99: 885-894.
  • 30. Gutiérrez-Enríquez S, Ramón y Cajal T. Breast cancer susceptibility genes. Med Clin (Barc).2006;126:304- 310.
  • 31. Elhaji YA, Gottlieb B, Lumbroso R, et al. The polymorphic CAG repeat of the androgen receptor gene: a potential role in breast cancer in women over 40. Breast Cancer Res Treat 2001;70:109-116.
  • 32. Di Fabio F, Alvarado C, Gologan A, et al. Somatic mosaicism of androgen receptor CAG repeats in colorectal carcinoma epithelial cells from men. J Surg Res 2009; 154 (1):38-44.
  • 33. Yu MW, Cheng SW, Lin MW, et al. Androgenreceptor gene CAG repeats, plasma testosterone levels, and risk of hepatitis B-related hepatocellular carcinoma. J Natl Cancer Inst. 2000 20;92: 2023- 2028.
  • 34. Awan AK, Iftikhar SY, Morris TM, et al. Androgen receptors may act in a paracrine manner to regulate oesophageal adenocarcinoma growth. Eur J Surg Oncol.2007;33: 561-568.
  • 35. Tihan T, Harmon JW, Wan X. Evidence of androgen receptor expression in squamous and adenocarcinoma of the esophagus. Anticancer Res. 2001;21:3107- 3114.
  • 36. Ito K, Suzuki T, Akahira J, et al. Expression of androgen receptor and 5alpha-reductases in the human normal endometrium and its disorders. Int J Cancer. 2002;99: 652-657.
  • 37. Rodríguez G, Bilbao C, Ramírez R, et al. Alleles with short CAG and GGN repeats in the androgen receptor gene are associated with benign endometrial cancer. Int J Cancer. 2006;118:1420-1425.
  • 38. Li AJ, Elmore RG, Pavelka JC, Karlan BY. Hyperandrogenism, mediated by obesity and receptor polymorphisms, promotes aggressive epithelial ovarian cancer biology. Gynecol Oncol. 2007;107:420-423.
  • 39. Li AJ, Scoles DR, Armstrong KU, Karlan BY. Androgen receptor cytosine-adenine-guanine repeat polymorphisms modulate EGFR signaling in epithelial ovarian carcinomas. Gynecol Oncol. 2008;109:220-225.
  • 40. Levine DA, Boyd J. The androgen receptor and genetic susceptibility to ovarian cancer: results from a case series. Cancer Res. 2001 1;61: 908-911.
  • 41. dos Santos ML, Sibov TT, Nishimoto IN, Kowalski LP, Miracca EC, Nagai MA. The CAG repeat polymorphism in the androgen receptor gene (AR) and its relationship to head and neck cancer. Oral Oncol. 2004;40:177-182.
  • 42. Chen YS, Hua KQ. Expression of androgen receptor in the vaginal wall and cardinal ligament of patients with pelvic organ prolapse. Zhonghua Yi Xue Za Zhi. 2008;88: 2920-2923.
  • 43. Langdahl BL, Stenkjaer L, Carstens M, Tofteng CL, Eriksen EF. A CAG repeat polymorphism in the androgen receptor gene is associated with reduced bone mass and increased risk of osteoporotic fractures. Calcif Tissue Int. 2003;73:237-243.
  • 44. Stanworth RD, Kapoor D, Channer KS, Jones TH. Androgen receptor CAG repeat polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes. Eur J Endocrinol 2008 159: 739-746.
  • 45. Mifsud A, Ramirez S, Yong EL. Androgen receptor gene CAG trinucleotide repeats in anovulatory infertility and polycystic ovaries. J Clin Endocrinol Metab. 2000;85: 3484-3488.
  • 46. Kim JJ, Choung SH, Choi YM, Yoon SH, Kim SH, Moon SY. Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome. Fertil Steril. 2008;90: 2318-2323.
  • 47. Jakubowski L. Genetic aspects of polycystic ovary syndrome. Endokrynol Pol. 2005;56: 285-293.
  • 48. Sawaya ME, Shalita AR. Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne. J Cutan Med Surg. 1998;3: 9-15.
  • 49. Hersberger M, Muntwyler J, Funke H, et al. The CAG repeat polymorphism in the androgen receptor gene is associated with HDL-cholesterol but not with coronary atherosclerosis or myocardial infarction. Clin Chem. 2005;51:1110-1115.
  • 50. Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care. 2009;12:232-240.
There are 50 citations in total.

Details

Primary Language Turkish
Journal Section Review Makaleler
Authors

Esma Sarıkaya

Tayfun Güngör This is me

Gülnur Özakşit This is me

Leyla Mollamahmutoğlu This is me

Publication Date April 27, 2015
Published in Issue Year 2010 Volume: 23 Issue: 2

Cite

APA Sarıkaya, E., Güngör, T., Özakşit, G., Mollamahmutoğlu, L. (2015). ANDROJEN RESEPTÖR GENİ VE JİNEKOLOJİ, İNFERTİLİTE VE ONKOLOJİ İÇİN KLİNİK ÖNEMİ. Marmara Medical Journal, 23(2), 2010-322.
AMA Sarıkaya E, Güngör T, Özakşit G, Mollamahmutoğlu L. ANDROJEN RESEPTÖR GENİ VE JİNEKOLOJİ, İNFERTİLİTE VE ONKOLOJİ İÇİN KLİNİK ÖNEMİ. Marmara Med J. August 2015;23(2):2010-322.
Chicago Sarıkaya, Esma, Tayfun Güngör, Gülnur Özakşit, and Leyla Mollamahmutoğlu. “ANDROJEN RESEPTÖR GENİ VE JİNEKOLOJİ, İNFERTİLİTE VE ONKOLOJİ İÇİN KLİNİK ÖNEMİ”. Marmara Medical Journal 23, no. 2 (August 2015): 2010-322.
EndNote Sarıkaya E, Güngör T, Özakşit G, Mollamahmutoğlu L (August 1, 2015) ANDROJEN RESEPTÖR GENİ VE JİNEKOLOJİ, İNFERTİLİTE VE ONKOLOJİ İÇİN KLİNİK ÖNEMİ. Marmara Medical Journal 23 2 2010–322.
IEEE E. Sarıkaya, T. Güngör, G. Özakşit, and L. Mollamahmutoğlu, “ANDROJEN RESEPTÖR GENİ VE JİNEKOLOJİ, İNFERTİLİTE VE ONKOLOJİ İÇİN KLİNİK ÖNEMİ”, Marmara Med J, vol. 23, no. 2, pp. 2010–322, 2015.
ISNAD Sarıkaya, Esma et al. “ANDROJEN RESEPTÖR GENİ VE JİNEKOLOJİ, İNFERTİLİTE VE ONKOLOJİ İÇİN KLİNİK ÖNEMİ”. Marmara Medical Journal 23/2 (August 2015), 2010-322.
JAMA Sarıkaya E, Güngör T, Özakşit G, Mollamahmutoğlu L. ANDROJEN RESEPTÖR GENİ VE JİNEKOLOJİ, İNFERTİLİTE VE ONKOLOJİ İÇİN KLİNİK ÖNEMİ. Marmara Med J. 2015;23:2010–322.
MLA Sarıkaya, Esma et al. “ANDROJEN RESEPTÖR GENİ VE JİNEKOLOJİ, İNFERTİLİTE VE ONKOLOJİ İÇİN KLİNİK ÖNEMİ”. Marmara Medical Journal, vol. 23, no. 2, 2015, pp. 2010-322.
Vancouver Sarıkaya E, Güngör T, Özakşit G, Mollamahmutoğlu L. ANDROJEN RESEPTÖR GENİ VE JİNEKOLOJİ, İNFERTİLİTE VE ONKOLOJİ İÇİN KLİNİK ÖNEMİ. Marmara Med J. 2015;23(2):2010-322.