ÜLSERATİF KOLİTLİ HASTALARIN NON-NEOPLASTİK İNFLAME KOLONİK MUKOZALARINDA MİKROSATELLİT İNSTABİLİTESİ

Year 2009, Volume: 22 Issue: 1, 12 - 18, 04.05.2015

Özlen Atuğ Mustafa Akkiprik Fatih Eren Arzu Tiftikçi Filiz Türe Özdemir Faruk Aşıcıoğlu Hülya Över Hamzaoğlu Nurdan Tözün

Abstract

Giriş ve Amaç: Ülseratif kolit (ÜK), zemininde kanser gelişme riski yüksek olan kronik inflamatuar bir
kolon hastalığıdır. ÜK ile ilişkili kanser gelişimine işaret edecek moleküler bir belirtece ihtiyaç
duyulmaktadır. ÜK ile ilişkili kolorektal kanserlerde DNA tamir mekanizmasındaki yetersizliğin ve genomik
mutasyonların bir belirteci olan mikrosatellit instabilitesinin (MSİ) varlığı gösterilmiştir. ÜK’te neoplastik ve
şiddetli inflamasyon görülen neoplastik olmayan mukozada MSİ’ni gösteren bazı çalışmalar mevcuttur. Bu
çalışmanın amacı neoplastik olmayan hafif-orta derecede inflame ÜK mukozasında MSİ’nin varlığını
araştırmaktır.
Gereç ve Yöntem: ÜK’li 29 hastanın inflame kolonik mucosa örneklerinde multipleks PCR (polimeraz
zincir reaksiyonu) ile standart 5 adet belirteç (BAT-25, BAT-26, D2S123, D5S346, D17S250) kullanılarak
MSİ’nin varlığı araştırıldı.
Bulgular: ÜK’li hastaların neoplastik olmayan hafif-orta derecede inflame mukozalarında MSİ saptanmadı.
Sonuç: ÜK’te MSİ’ni değerlendirirken mukozadaki inflamasyonun derecesi göz önünde bulundurulmalıdır.

Keywords

Ülseratif kolit, Mikrosatellit instabilite

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