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Year 2008, Volume: 21 Issue: 1, 89 - 101, 24.06.2015

Abstract

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References

  • 1. Rorman E, Zamir CS, Rilkis I, Ben-David H. Congenital toxoplasmosis--prenatal aspects of Toxoplasma gondii infection. Reprod Toxicol 2006; 21: 458-472.
  • 2. Remington JS, McLeod R, Thulliez P, Desmonts G. Toxoplasmosis. In: Remington SS, Klein JO, Wilson CB, Baker CJ, eds. Infectious Diseases of the Fetus and Newborn Infant. 6th ed. Philadelphia, PA, IL: Elsevier Saunders; 2006: 947-1091.
  • 3. Kravetz JD, Federman DG. Toxoplasmosis in pregnancy. Am J Med 2005; 118: 212-216.
  • 4. Suzuki Y, Wong SY, Grumet FC, et al. Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients. J Infect Dis 1996; 173: 265-268.
  • 5. Mack DG, Johnson JJ, Roberts F, Roberts CW, Estes RG, David C, et al. HLA-class II genes modify outcome of Toxoplasma gondii infection. Int J Parasitol 1999; 29: 1351-1358.
  • 6. Fatoohi AF, Cozon GJ, Wallon M, Kahi S, GayAndrieu F, Greenland T, et al. Cellular immunity to Toxoplasma gondii in congenitally infected newborns and immunocompetent infected hosts. Eur J Clin Microbiol Infect Dis 2003; 22: 181-184.
  • 7. Montoya JG, Liesenfeld O. Toxoplasmosis in pregnancy. Lancet 2004;363:1965-1976.
  • 8. Lekutis C, Ferguson DJ, Boothroyd JC. Toxoplasma gondii: identification of a developmentally regulated family of genes related to SAG2. Exp Parasitol 2000;96:89-96.
  • 9. Sibley LD. Intracellular parasite invasion strategies. Science 2004;304(5668):248-253.
  • 10. Kissinger JC, Gajria B, Li L, Paulsen IT, Roos DS. ToxoDB: accessing the Toxoplasma gondii genome. Nucleic Acids Res 2003; 31: 234-236.
  • 11. Chardes T, Buzoni-Gatel D, Lepage A, Bernard F, Bout D. Toxoplasma gondii oral infection induces specific cytotoxic CD8 alpha/beta+ Thy-1+ gut intraepithelial lymphocytes, lytic for parasite-infected enterocytes. J Immunol 1994; 153: 4596-4603
  • 12. Mineo JR, McLeod R, Mack D, Smith J, Khan IA, Ely KH, et al. Antibodies to Toxoplasma gondii major surface protein (SAG-1, P30) inhibit infection of host cells and are produced in murine intestine after peroral infection. J Immunol 1993; 150: 3951-3964.
  • 13. Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans. Int J Parasitol 2000; 30: 1217-58.
  • 14. Jones JL, Kruszon-Moran D, Wilson M, McQuillan G, Navin T, McAuley JB. Toxoplasma gondii infection in the United States: seroprevalence and risk factors. Am J Epidemiol 2001; 154: 357-365.
  • 15. Aslan G, Altıntaş K, Seyrek A, Kültür N, Güngör Ç. Şanlıurfa bölgesindeki kadınlarda Sabin-Feldman testi ile toksoplazma gondii prevalansının saptanması. Erciyes Tıp Dergisi 1998;20:149-153.
  • 16. Güngör Ç, Özsan M, Karaarslan M. Hamileleerde toksoplasma total, IgM ve Ig6 antikor seropozitifliğinin araştırılması. Ankara Üniversitesi Tıp Fakültesi Mecmuası 2000; 53:91-93.
  • 17. Kapperud G, Jenum PA, Stray-Pedersen B, Melby KK, Eskild A, Eng J. Risk factors for Toxoplasma gondii infection in pregnancy. Results of a prospective case-control study in Norway. Am J Epidemiol 1996; 144: 405-412.
  • 18. Buffolano W, Gilbert RE, Holland FJ, Fratta D, Palumbo F, Ades AE. Risk factors for recent toxoplasma infection in pregnant women in Naples. Epidemiol Infect 1996; 116: 347-351.
  • 19. Bobic B, Jevremovic I, Marinkovic J, Sibalic D, Djurkovic-Djakovic O. Risk factors for Toxoplasma infection in a reproductive age female population in the area of Belgrade, Yugoslavia. Eur J Epidemiol 1998; 14: 605-610.
  • 20. Cook AJ, Gilbert RE, Buffolano W, Zufferey J, Petersen E, Jenum PA, et al. Sources of toxoplasma infection in pregnant women: European multicentre case-control study. European Research Network on Congenital Toxoplasmosis. Bmj 2000; 321: 142-147.
  • 21. Boyer KM, Holfels E, Roizen N, Swisher C, Mack D, Remington J, et al. Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: Implications for prenatal management and screening. Am J Obstet Gynecol 2005; 192: 564- 571.
  • 22. Toker A, İplikçi MT, Ersöz M, Eriş FN.Hamile kadınlarda toksoplazma antikorlarına rastlama sıklığı ve beslenme ile ilişkisi. Türkiye Parazitoloji Dergisi 1994,18:277-285.
  • 23. Jones J, Lopez A, Wilson M. Congenital toxoplasmosis. Am Fam Physician 2003; 67: 2131- 2138.
  • 24. Dubey JP. Toxoplasmosis. J Am Vet Med Assoc 1994; 205: 1593-1598.
  • 25. Antsaklis A, Daskalakis G, Papantoniou N, Mentis A, Michalas S. Prenatal diagnosis of congenital toxoplasmosis. Prenat Diagn 2002; 22: 1107-1111.
  • 26. Dollfus H, Dureau P, Hennequin C, Uteza Y, Bron A, Dufier JL. Congenital toxoplasma chorioretinitis transmitted by preconceptionally immune women. Br J Ophthalmol 1998; 82: 1444-1445.
  • 27. Chemla C, Villena I, Aubert D, Hornoy P, Dupouy D, Leroux B, et al. Preconception seroconversion and maternal seronegativity at delivery do not rule out the risk of congenital toxoplasmosis. Clin Diagn Lab Immunol 2002; 9: 489-490.
  • 28. Silveira C, Ferreira R, Muccioli C, Nussenblatt R, Belfort R, Jr. Toxoplasmosis transmitted to a newborn from the mother infected 20 years earlier. Am J Ophthalmol 2003; 136: 370-371.
  • 29. Lebech M, Joynson DH, Seitz HM, Thulliez P, Gilbert RE, Dutton GN, et al. Classification system and case definitions of Toxoplasma gondii infection in immunocompetent pregnant women and their congenitally infected offspring. European Research Network on Congenital Toxoplasmosis. Eur J Clin Microbiol Infect Dis 1996; 15: 799-805.
  • 30. Lappalainen M, Hedman K. Serodiagnosis of toxoplasmosis. The impact of measurement of IgG avidity. Ann Ist Super Sanita 2004; 40: 81-88.
  • 31. Gay-Andrieu F, Marty P, Pialat J, Sournies G, Drier de Laforte T, Peyron F. Fetal toxoplasmosis and negative amniocentesis: necessity of an ultrasound follow-up. Prenat Diagn 2003; 23: 558-560.
  • 32. McAuley J, Boyer KM, Patel D, Mets M, Swisher C, Roizen N, et al. Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial. Clin Infect Dis 1994; 18: 38-72.
  • 33. Swisher CN, Boyer K, McLeod R. Congenital toxoplasmosis. The Toxoplasmosis Study Group. Semin Pediatr Neurol 1994; 1: 4-25.
  • 34. Gras L, Wallon M, Pollak A, et al. Association between prenatal treatment and clinical manifestations of congenital toxoplasmosis in infancy: a cohort study in 13 European centres. Acta Paediatr 2005; 94: 1721- 1731.
  • 35. Vutova K, Peicheva Z, Popova A, Markova V, Mincheva N, Todorov T. Congenital toxoplasmosis: eye manifestations in infants and children. Ann Trop Paediatr 2002; 22: 213-218.
  • 36. Potasman I, Davidovitch M, Tal Y, Tal J, Zelnik N, Jaffe M. Congenital toxoplasmosis: a significant cause of neurological morbidity in Israel? Clin Infect Dis 1995; 20: 259-262.
  • 37. Montoya JG. Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis. J Infect Dis 2002; 185 Suppl 1: S73-82.
  • 38. Hedman K, Lappalainen M, Seppaia I, Makela O. Recent primary toxoplasma infection indicated by a low avidity of specific IgG. J Infect Dis 1989; 159: 736-740.
  • 39. Montoya JG, Liesenfeld O, Kinney S, Press C, Remington JS. VIDAS test for avidity of Toxoplasma-specific immunoglobulin G for confirmatory testing of pregnant women. J Clin Microbiol 2002; 40: 2504-2508.
  • 40. Jenum PA, Stray-Pedersen B, Gundersen AG. Improved diagnosis of primary Toxoplasma gondii infection in early pregnancy by determination of antitoxoplasma immunoglobulin G avidity. J Clin Microbiol 1997; 35: 1972-1977.
  • 41. Lappalainen M, Koskela P, Koskiniemi M, et al. Toxoplasmosis acquired during pregnancy: improved serodiagnosis based on avidity of IgG. J Infect Dis 1993; 167: 691-697.
  • 42. Dannemann BR, Vaughan WC, Thulliez P, Remington JS. Differential agglutination test for diagnosis of recently acquired infection with Toxoplasma gondii. J Clin Microbiol 1990; 28: 1928- 1933.
  • 43. Liesenfeld O, Press C, Montoya JG, et al. Falsepositive results in immunoglobulin M (IgM) toxoplasma antibody tests and importance of confirmatory testing: the Platelia Toxo IgM test. J Clin Microbiol 1997; 35: 174-178.
  • 44. Bobic B, Sibalic D, Djurkovic-Djakovic O. High levels of IgM antibodies specific for Toxoplasma gondii in pregnancy 12 years after primary toxoplasma infection. Case report. Gynecol Obstet Invest 1991; 31: 182-184.
  • 45. Wilson M, Remington JS, Clavet C, Varney G, Press C, Ware D. Evaluation of six commercial kits for detection of human immunoglobulin M antibodies to Toxoplasma gondii. The FDA Toxoplasmosis Ad Hoc Working Group. J Clin Microbiol 1997; 35: 3112- 3115.
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KONJENİTAL TOXOPLASMA GONDİİ ENFEKSİYONU

Year 2008, Volume: 21 Issue: 1, 89 - 101, 24.06.2015

Abstract

Hamile kadınlar Toxoplasma gondii enfeksiyonunu genellikle asemptomatik olarak geçirmelerine rağmen bebeklerini enfekte ederek onlarda bu enfeksiyona bağlı ciddi sekellere neden olurlar. T. gondii enfeksiyonu fetusda mental retardasyon, havale, körlük ve ölüm gibi ciddi sağlık problemleri ile sonuçlanır. Bu sağlık problemlerinden bazıları 20`li ve 30`lu yaşlara kadar ortaya çıkmayabilir. Gebede akut T. gondii enfeksiyonu tanısında serolojik testler kullanılır. Bu testlerde sıklıkla yalancı pozitif sonuçlara rastlanılır. Bu nedenle potansiyel toksik etkileri olan ilaçlarla tedaviye baslamadan önce mutlaka pozitif serolojik test sonuçları referans laboratuvarında doğrulanmalıdır. Çoğu durumda konjenital toksoplasmosis hamile kadınların ve diğer doğurganlık yaşında olan kadınların çiğ veya pişmemiş et ürünleri tüketmemeleri, bu tür gıdalarla kontaminasyondan kaçınmaları ve kontamine toprak veya enfekte kedilerin dıskı kaplarına maruz kalmaları durumlarında kendilerini korumaları konularında eğitilmeleri ile önlenebilir.

References

  • 1. Rorman E, Zamir CS, Rilkis I, Ben-David H. Congenital toxoplasmosis--prenatal aspects of Toxoplasma gondii infection. Reprod Toxicol 2006; 21: 458-472.
  • 2. Remington JS, McLeod R, Thulliez P, Desmonts G. Toxoplasmosis. In: Remington SS, Klein JO, Wilson CB, Baker CJ, eds. Infectious Diseases of the Fetus and Newborn Infant. 6th ed. Philadelphia, PA, IL: Elsevier Saunders; 2006: 947-1091.
  • 3. Kravetz JD, Federman DG. Toxoplasmosis in pregnancy. Am J Med 2005; 118: 212-216.
  • 4. Suzuki Y, Wong SY, Grumet FC, et al. Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients. J Infect Dis 1996; 173: 265-268.
  • 5. Mack DG, Johnson JJ, Roberts F, Roberts CW, Estes RG, David C, et al. HLA-class II genes modify outcome of Toxoplasma gondii infection. Int J Parasitol 1999; 29: 1351-1358.
  • 6. Fatoohi AF, Cozon GJ, Wallon M, Kahi S, GayAndrieu F, Greenland T, et al. Cellular immunity to Toxoplasma gondii in congenitally infected newborns and immunocompetent infected hosts. Eur J Clin Microbiol Infect Dis 2003; 22: 181-184.
  • 7. Montoya JG, Liesenfeld O. Toxoplasmosis in pregnancy. Lancet 2004;363:1965-1976.
  • 8. Lekutis C, Ferguson DJ, Boothroyd JC. Toxoplasma gondii: identification of a developmentally regulated family of genes related to SAG2. Exp Parasitol 2000;96:89-96.
  • 9. Sibley LD. Intracellular parasite invasion strategies. Science 2004;304(5668):248-253.
  • 10. Kissinger JC, Gajria B, Li L, Paulsen IT, Roos DS. ToxoDB: accessing the Toxoplasma gondii genome. Nucleic Acids Res 2003; 31: 234-236.
  • 11. Chardes T, Buzoni-Gatel D, Lepage A, Bernard F, Bout D. Toxoplasma gondii oral infection induces specific cytotoxic CD8 alpha/beta+ Thy-1+ gut intraepithelial lymphocytes, lytic for parasite-infected enterocytes. J Immunol 1994; 153: 4596-4603
  • 12. Mineo JR, McLeod R, Mack D, Smith J, Khan IA, Ely KH, et al. Antibodies to Toxoplasma gondii major surface protein (SAG-1, P30) inhibit infection of host cells and are produced in murine intestine after peroral infection. J Immunol 1993; 150: 3951-3964.
  • 13. Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans. Int J Parasitol 2000; 30: 1217-58.
  • 14. Jones JL, Kruszon-Moran D, Wilson M, McQuillan G, Navin T, McAuley JB. Toxoplasma gondii infection in the United States: seroprevalence and risk factors. Am J Epidemiol 2001; 154: 357-365.
  • 15. Aslan G, Altıntaş K, Seyrek A, Kültür N, Güngör Ç. Şanlıurfa bölgesindeki kadınlarda Sabin-Feldman testi ile toksoplazma gondii prevalansının saptanması. Erciyes Tıp Dergisi 1998;20:149-153.
  • 16. Güngör Ç, Özsan M, Karaarslan M. Hamileleerde toksoplasma total, IgM ve Ig6 antikor seropozitifliğinin araştırılması. Ankara Üniversitesi Tıp Fakültesi Mecmuası 2000; 53:91-93.
  • 17. Kapperud G, Jenum PA, Stray-Pedersen B, Melby KK, Eskild A, Eng J. Risk factors for Toxoplasma gondii infection in pregnancy. Results of a prospective case-control study in Norway. Am J Epidemiol 1996; 144: 405-412.
  • 18. Buffolano W, Gilbert RE, Holland FJ, Fratta D, Palumbo F, Ades AE. Risk factors for recent toxoplasma infection in pregnant women in Naples. Epidemiol Infect 1996; 116: 347-351.
  • 19. Bobic B, Jevremovic I, Marinkovic J, Sibalic D, Djurkovic-Djakovic O. Risk factors for Toxoplasma infection in a reproductive age female population in the area of Belgrade, Yugoslavia. Eur J Epidemiol 1998; 14: 605-610.
  • 20. Cook AJ, Gilbert RE, Buffolano W, Zufferey J, Petersen E, Jenum PA, et al. Sources of toxoplasma infection in pregnant women: European multicentre case-control study. European Research Network on Congenital Toxoplasmosis. Bmj 2000; 321: 142-147.
  • 21. Boyer KM, Holfels E, Roizen N, Swisher C, Mack D, Remington J, et al. Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: Implications for prenatal management and screening. Am J Obstet Gynecol 2005; 192: 564- 571.
  • 22. Toker A, İplikçi MT, Ersöz M, Eriş FN.Hamile kadınlarda toksoplazma antikorlarına rastlama sıklığı ve beslenme ile ilişkisi. Türkiye Parazitoloji Dergisi 1994,18:277-285.
  • 23. Jones J, Lopez A, Wilson M. Congenital toxoplasmosis. Am Fam Physician 2003; 67: 2131- 2138.
  • 24. Dubey JP. Toxoplasmosis. J Am Vet Med Assoc 1994; 205: 1593-1598.
  • 25. Antsaklis A, Daskalakis G, Papantoniou N, Mentis A, Michalas S. Prenatal diagnosis of congenital toxoplasmosis. Prenat Diagn 2002; 22: 1107-1111.
  • 26. Dollfus H, Dureau P, Hennequin C, Uteza Y, Bron A, Dufier JL. Congenital toxoplasma chorioretinitis transmitted by preconceptionally immune women. Br J Ophthalmol 1998; 82: 1444-1445.
  • 27. Chemla C, Villena I, Aubert D, Hornoy P, Dupouy D, Leroux B, et al. Preconception seroconversion and maternal seronegativity at delivery do not rule out the risk of congenital toxoplasmosis. Clin Diagn Lab Immunol 2002; 9: 489-490.
  • 28. Silveira C, Ferreira R, Muccioli C, Nussenblatt R, Belfort R, Jr. Toxoplasmosis transmitted to a newborn from the mother infected 20 years earlier. Am J Ophthalmol 2003; 136: 370-371.
  • 29. Lebech M, Joynson DH, Seitz HM, Thulliez P, Gilbert RE, Dutton GN, et al. Classification system and case definitions of Toxoplasma gondii infection in immunocompetent pregnant women and their congenitally infected offspring. European Research Network on Congenital Toxoplasmosis. Eur J Clin Microbiol Infect Dis 1996; 15: 799-805.
  • 30. Lappalainen M, Hedman K. Serodiagnosis of toxoplasmosis. The impact of measurement of IgG avidity. Ann Ist Super Sanita 2004; 40: 81-88.
  • 31. Gay-Andrieu F, Marty P, Pialat J, Sournies G, Drier de Laforte T, Peyron F. Fetal toxoplasmosis and negative amniocentesis: necessity of an ultrasound follow-up. Prenat Diagn 2003; 23: 558-560.
  • 32. McAuley J, Boyer KM, Patel D, Mets M, Swisher C, Roizen N, et al. Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial. Clin Infect Dis 1994; 18: 38-72.
  • 33. Swisher CN, Boyer K, McLeod R. Congenital toxoplasmosis. The Toxoplasmosis Study Group. Semin Pediatr Neurol 1994; 1: 4-25.
  • 34. Gras L, Wallon M, Pollak A, et al. Association between prenatal treatment and clinical manifestations of congenital toxoplasmosis in infancy: a cohort study in 13 European centres. Acta Paediatr 2005; 94: 1721- 1731.
  • 35. Vutova K, Peicheva Z, Popova A, Markova V, Mincheva N, Todorov T. Congenital toxoplasmosis: eye manifestations in infants and children. Ann Trop Paediatr 2002; 22: 213-218.
  • 36. Potasman I, Davidovitch M, Tal Y, Tal J, Zelnik N, Jaffe M. Congenital toxoplasmosis: a significant cause of neurological morbidity in Israel? Clin Infect Dis 1995; 20: 259-262.
  • 37. Montoya JG. Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis. J Infect Dis 2002; 185 Suppl 1: S73-82.
  • 38. Hedman K, Lappalainen M, Seppaia I, Makela O. Recent primary toxoplasma infection indicated by a low avidity of specific IgG. J Infect Dis 1989; 159: 736-740.
  • 39. Montoya JG, Liesenfeld O, Kinney S, Press C, Remington JS. VIDAS test for avidity of Toxoplasma-specific immunoglobulin G for confirmatory testing of pregnant women. J Clin Microbiol 2002; 40: 2504-2508.
  • 40. Jenum PA, Stray-Pedersen B, Gundersen AG. Improved diagnosis of primary Toxoplasma gondii infection in early pregnancy by determination of antitoxoplasma immunoglobulin G avidity. J Clin Microbiol 1997; 35: 1972-1977.
  • 41. Lappalainen M, Koskela P, Koskiniemi M, et al. Toxoplasmosis acquired during pregnancy: improved serodiagnosis based on avidity of IgG. J Infect Dis 1993; 167: 691-697.
  • 42. Dannemann BR, Vaughan WC, Thulliez P, Remington JS. Differential agglutination test for diagnosis of recently acquired infection with Toxoplasma gondii. J Clin Microbiol 1990; 28: 1928- 1933.
  • 43. Liesenfeld O, Press C, Montoya JG, et al. Falsepositive results in immunoglobulin M (IgM) toxoplasma antibody tests and importance of confirmatory testing: the Platelia Toxo IgM test. J Clin Microbiol 1997; 35: 174-178.
  • 44. Bobic B, Sibalic D, Djurkovic-Djakovic O. High levels of IgM antibodies specific for Toxoplasma gondii in pregnancy 12 years after primary toxoplasma infection. Case report. Gynecol Obstet Invest 1991; 31: 182-184.
  • 45. Wilson M, Remington JS, Clavet C, Varney G, Press C, Ware D. Evaluation of six commercial kits for detection of human immunoglobulin M antibodies to Toxoplasma gondii. The FDA Toxoplasmosis Ad Hoc Working Group. J Clin Microbiol 1997; 35: 3112- 3115.
  • 46. Hohlfeld P, Daffos F, Costa JM, Thulliez P, Forestier F, Vidaud M. Prenatal diagnosis of congenital toxoplasmosis with a polymerase-chain-reaction test on amniotic fluid. N Engl J Med 1994; 331: 695-699.
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There are 78 citations in total.

Details

Primary Language Turkish
Journal Section Review Makaleler
Authors

Nazan Dalgıç This is me

Publication Date June 24, 2015
Published in Issue Year 2008 Volume: 21 Issue: 1

Cite

APA Dalgıç, N. (2015). KONJENİTAL TOXOPLASMA GONDİİ ENFEKSİYONU. Marmara Medical Journal, 21(1), 89-101.
AMA Dalgıç N. KONJENİTAL TOXOPLASMA GONDİİ ENFEKSİYONU. Marmara Med J. August 2015;21(1):89-101.
Chicago Dalgıç, Nazan. “KONJENİTAL TOXOPLASMA GONDİİ ENFEKSİYONU”. Marmara Medical Journal 21, no. 1 (August 2015): 89-101.
EndNote Dalgıç N (August 1, 2015) KONJENİTAL TOXOPLASMA GONDİİ ENFEKSİYONU. Marmara Medical Journal 21 1 89–101.
IEEE N. Dalgıç, “KONJENİTAL TOXOPLASMA GONDİİ ENFEKSİYONU”, Marmara Med J, vol. 21, no. 1, pp. 89–101, 2015.
ISNAD Dalgıç, Nazan. “KONJENİTAL TOXOPLASMA GONDİİ ENFEKSİYONU”. Marmara Medical Journal 21/1 (August 2015), 89-101.
JAMA Dalgıç N. KONJENİTAL TOXOPLASMA GONDİİ ENFEKSİYONU. Marmara Med J. 2015;21:89–101.
MLA Dalgıç, Nazan. “KONJENİTAL TOXOPLASMA GONDİİ ENFEKSİYONU”. Marmara Medical Journal, vol. 21, no. 1, 2015, pp. 89-101.
Vancouver Dalgıç N. KONJENİTAL TOXOPLASMA GONDİİ ENFEKSİYONU. Marmara Med J. 2015;21(1):89-101.