Abstract
-
Keywords
References
- Stuart J Schnitt. The diagnosis and management of preinvasive
- breast disease: Flat epithelial atypia –
- classification, pathologic features and clinical
- significance. Breast Cancer Res. 2003; 5(5): 263–268
- Oyama T, Iijima K, Takei H, et al. Atypical cystic
- lobule of the breast: an early stage of low-grade ductal
- carcinoma in-situ. Breast Cancer. 2000;7:326–331.
- Eusebi V, Feudale E, Foschini MP, et al. Long-term
- follow-up of in situ carcinoma of the breast. Semin
- Diagn Pathol 1994;11:223–235.
- Moinfar F, Man YG, Bratthauer GL, Ratschek M,
- Tavassoli FA. Genetic abnormalities in mammary ductal
- intraepithelial neoplasia-flat type ('clinging ductal
- carcinoma in situ'): a simulator of normal mammary
- epithelium. Cancer. 2000;88:2072–2081.
- Rosen PP. Columnar cell hyperplasia is associated with
- lobular carcinoma in situ and tubular carcinoma [letter].
- Am J Surg Pathol. 1999;23:1561.
- Goldstein NS, O'Malley BA. Cancerization of small
- ectatic ducts of the breast by ductal carcinoma in situ
- cells with apocrine snouts: a lesion associated with
- tubular carcinoma. Am J Clin Pathol. 1997;107:561–
- -
- Shin SJ, Rosen PP. Carcinoma arising from preexisting
- pregnancy-like and cystic hypersecretory hyperplasia
- lesions of the breast: a clinicopathologic study of 9
- patients. Am J Surg Pathol. 2004;28(6):789-793.
- Tavassoli FA, Hoefler H, Rosai J, Holland R, Ellis I,
- Schnitt S, Lakhani SRM, Boecker W, HeywangKobrunner
- SH, Moinfar F, Peterse J. Intraductal
- proliferative lesions. In: Tavassoli FA, Devilee P, editor.
- Pathology and Genetics of Tumours of the Breast and
- Female Genital Organs. Lyon: IARC Press. 2003; 182-
- -
- Fraser JL, Raza S, Chorny K, Connolly JL, Schnitt
- SJ.Columnar alteration with prominent apical snouts and
- secretions: a spectrum of changes frequently present in
- breast biopsies performed for microcalcifications. Am J
- Surg Pathol. 1998;22(12):1521-1527.
- Dabbs DJ, Carter G, Fudge M, Peng Y, Swalsky P,
- Finkelstein S. Molecular alterations in columnar cell
- lesions of the breast. Mod. Pathol 2006; 19: 344-349.
- Vincent-Salomon A. Columnar lesions: a frequent
- diagnosis in breast pathology. Ann Pathol 2003;
- (6):593-596.
- Sahoo S, Recant WM. Triad of columnar cell alteration,
- lobular carcinoma in situ, and tubular carcinoma of the
- breast. Breast J. 2005; 11(2):140-142.
- Shin SJ, Rosen PP. Pregnancy-like (Pseudolactational)
- hyperplasia: A primary diagnosis in mammographically
- dedected lesions of the breast and its relationships to
- cystic hypersecretory hyperplasia. Am J Surg Pathol.
- ; 24(12): 1670-1674.
- Okten T, Öztürk F. Memenin Sekretuar Karsinomu
- Erciyes Tıp Dergisi 1993; 15 (4): 435-437
Abstract
Memenin kolumnar hücreli lezyonları dilate terminal duktal lobuler ünitlerden kaynaklanan az ya da belirgin sitolojik ve yapısal atipi içeren lezyonlardır. Bu makalede sunulan olgu 48 yaşında kadın olup sol memesinde 2 cm çapta kitlesi mevcuttur. Bu lezyona yapılan ince iğne aspirasyon biyopsisi malign epitelyal hücreler, tru-cut biyopsi fibroadenom olarak rapor edilmiştir. Beş gün sonra lumpektomi + sentinel lenf nodu biyopsisi operasyonu uygulanan hastanın frozen sonucu sellüler fibroadenom versus benign filloides tümör ve tümör negatif sentinel lenf nodu olarak bildirilmiştir. Spesmenin formalin fiksasyonu takiben yapılan mikroskopik incelemesinde sınırları düzgün, kapsülsüz lezyon izlenmiştir. Stroma içerisinde lümenleri çoğunlukla boş, dilate, psodostratifiye alçak kolumnar epitelle döşeli duktuslar gözlenmiştir. Duktal hücre nukleusları iri, çoğunlukla belirgin nükleollu olup hücre bazaline yerleşmiş oldukları dikkati çekmiştir. Duktal hücrelerin apikal tarafta sitoplazmik sekret benzeri materyal içerdiği görülmüştür. Bu sonuçlarla olguya atipik kolumnar hücre hiperplazisi tanısı konulmuştur. Olgu memenin nadir görülen lezyolarından olması ve iğne aspirasyon biyopsisi, tru-cut biyopsi ve frozenda tanı güçlüğü oluşturması yanısıra memenin atipi gösteren diğer lezyonlarından ayırıcı tanısının zor olması nedeni ile sunulmuştur.
Anahtar Kelimeler: Kolumnar hücreli lezyon, Atipik hiperplazi, Meme
Keywords
References
- Stuart J Schnitt. The diagnosis and management of preinvasive
- breast disease: Flat epithelial atypia –
- classification, pathologic features and clinical
- significance. Breast Cancer Res. 2003; 5(5): 263–268
- Oyama T, Iijima K, Takei H, et al. Atypical cystic
- lobule of the breast: an early stage of low-grade ductal
- carcinoma in-situ. Breast Cancer. 2000;7:326–331.
- Eusebi V, Feudale E, Foschini MP, et al. Long-term
- follow-up of in situ carcinoma of the breast. Semin
- Diagn Pathol 1994;11:223–235.
- Moinfar F, Man YG, Bratthauer GL, Ratschek M,
- Tavassoli FA. Genetic abnormalities in mammary ductal
- intraepithelial neoplasia-flat type ('clinging ductal
- carcinoma in situ'): a simulator of normal mammary
- epithelium. Cancer. 2000;88:2072–2081.
- Rosen PP. Columnar cell hyperplasia is associated with
- lobular carcinoma in situ and tubular carcinoma [letter].
- Am J Surg Pathol. 1999;23:1561.
- Goldstein NS, O'Malley BA. Cancerization of small
- ectatic ducts of the breast by ductal carcinoma in situ
- cells with apocrine snouts: a lesion associated with
- tubular carcinoma. Am J Clin Pathol. 1997;107:561–
- -
- Shin SJ, Rosen PP. Carcinoma arising from preexisting
- pregnancy-like and cystic hypersecretory hyperplasia
- lesions of the breast: a clinicopathologic study of 9
- patients. Am J Surg Pathol. 2004;28(6):789-793.
- Tavassoli FA, Hoefler H, Rosai J, Holland R, Ellis I,
- Schnitt S, Lakhani SRM, Boecker W, HeywangKobrunner
- SH, Moinfar F, Peterse J. Intraductal
- proliferative lesions. In: Tavassoli FA, Devilee P, editor.
- Pathology and Genetics of Tumours of the Breast and
- Female Genital Organs. Lyon: IARC Press. 2003; 182-
- -
- Fraser JL, Raza S, Chorny K, Connolly JL, Schnitt
- SJ.Columnar alteration with prominent apical snouts and
- secretions: a spectrum of changes frequently present in
- breast biopsies performed for microcalcifications. Am J
- Surg Pathol. 1998;22(12):1521-1527.
- Dabbs DJ, Carter G, Fudge M, Peng Y, Swalsky P,
- Finkelstein S. Molecular alterations in columnar cell
- lesions of the breast. Mod. Pathol 2006; 19: 344-349.
- Vincent-Salomon A. Columnar lesions: a frequent
- diagnosis in breast pathology. Ann Pathol 2003;
- (6):593-596.
- Sahoo S, Recant WM. Triad of columnar cell alteration,
- lobular carcinoma in situ, and tubular carcinoma of the
- breast. Breast J. 2005; 11(2):140-142.
- Shin SJ, Rosen PP. Pregnancy-like (Pseudolactational)
- hyperplasia: A primary diagnosis in mammographically
- dedected lesions of the breast and its relationships to
- cystic hypersecretory hyperplasia. Am J Surg Pathol.
- ; 24(12): 1670-1674.
- Okten T, Öztürk F. Memenin Sekretuar Karsinomu
- Erciyes Tıp Dergisi 1993; 15 (4): 435-437
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Reports |
| Authors | |
| Publication Date | June 24, 2015 |
| Published in Issue | Year 2008 Volume: 21 Issue: 2 |