MİTOKONDRİYAL DNA VE KANSER

Year 2007, Volume: 20 Issue: 2, 127 - 136, 25.06.2015

Cenk Aral Ayşe Özer

Abstract

Mitokondriyal DNA' nın, nükleer DNA' ya kıyasla mutasyonlara daha duyarlı olması ve tamir mekanizmalarının sınırlılığı nedeniyle karsinogenezde rol aldığı öne sürülmüştür. Bu derlemede tiroid, kolorektal, meme ve gastrik kanserlerde, mitokondriyal genom kararsızlığı, mitokondriyal DNA mutasyonlarının apoptozis ile ilişkisi ve mitokondriyal genomdaki değişimler değerlendirilmiştir.

Anahtar Kelimeler: Mitokondriyal DNA, Genomik kararsızlık, Apoptozis, Mutasyon, Solid tümörler

Keywords

Mitokondriyal DNA, Genomik kararsızlık, Apoptozis, Mutasyon, Solid tümörler

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