MEME KANSERİNDE UZUN SÜRELİ TAMOKSİFEN KULLANIMININ KADIN AŞAĞI GENİTAL TRAKTUS ÜZERİNE ETKİSİ

Year 2007, Volume: 20 Issue: 3, 196 - 201, 25.06.2015

Yusuf Yıldırım Emrah Toz

Abstract

Sentetik anti-östrojenik bir ilaç olan Tamoksifen (TAM) meme kanseri tedavisinde yaygın olarak kullanılmaktadır. Uzun süreli TAM kullanımı parsiyel agonistik etkisine bağlı olarak pre-malign ve malign uterin korpus lezyonları ve fonksiyonel ovaryen kistlere yol açabilir. Bununla birlikte, meme kanseri öyküsü olan hastalarda TAM kullanımı ile aşağı kadın genital sistemi lezyonları, örneğin servikal polip ve servikal intra-epitelyal neoplazi (CIN), arasındaki ilişki hakkında literatürde çok az veri vardır. Mevcut ‘review’ bu konu hakkında güncel bir derleme sunmaktadır.

Keywords

Tamoksifen, Meme kanseri, Kadın aşağı genital sistemi

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