Erişkin herediter anjiödem hastalarında danazol ile yapılan uzun dönem profilaksi tedavisine uyumun değerlendirilmesi: Gerçek bir yaşam çalışması

Year 2019, Volume: 32 Issue: 1, 7 - 13, 29.01.2019

Semra Demır Derya Unal Muge Olgac Asli Gelıncık Raif Coskun Bahauddin Colakoglu Suna Buyukozturk

https://doi.org/10.5472/marumj.518719

Cited By: 2

Abstract

Amaç: Herediter anjioödem (HAÖ) hastalarında profilaktik

tedaviye uyumu ve bunları etkileyen olası faktörleri araştırmaktır.

Hastalar ve Yöntemler: Altmış HAÖ hastasının tıbbi kayıtları

değerlendirildi ve demografik ve hastalıkları ile ilgili klinik

özellikler ve kullandıkları ilaçlar ile ilgili soruları içeren anketi

yanıtlamaları istendi. Hastalık ciddiyeti, semptomların başlangıç

yaşı, klinik bulguları ve uzun dönem profilaksi ihtiyacına göre

belirlendi.

Bulgular: Hastaların %65’i kadın, yaş ortalaması 38,07±12,38,

%93,3’ü tip 1 HAÖ, %58,3’ünün hastalığı ciddi idi ve %71,7’si

danazol ile profilaktik tedavi görüyordu. Ondört hasta proflaktik

tedavisini düzenli kullanmıyordu ve kullanmama nedenleri yan

etki gelişmesinden korkmak (n=11) ve ilacı almayı unutmak idi

(n=4). Ailede tek vaka olanların, HAÖ’li akrabası az olanların ve

ailesinde bu nedenle hayatlarını kaybeden akrabası olmayanların

profilaktik tedaviye daha uyumlu olduğu görüldü (P=0,008;

P=0,018; P=0,028).

Sonuç: Hastalarımızın büyük çoğunluğu proflaktik tedaviyi

düzenli kullanmakta ve bu tedaviden fayda görmektedir.

Uyumsuzluğun primer nedeni yan etki gelişimi korkusudur.

Keywords

Tedaviye uyum, Herediter anjioödem, Tedavi, Uzun dönem profilaksi, Danazol, Yan etkiler

Evaluating adherence to long-term prophylaxis treatment with danazol in adult hereditary angioedema patients: A real life study

Abstract

Objective: To investigate the adherence to the prophylactic

treatment in hereditary angioedema (HAE) patients as well as the

potential factors which may affect this situation.

Patients and Methods: In addition to evaluation of their

medical records, sixty HAE patients were asked to complete a

questionnaire including inquiries about demographic and clinical

features of their disease and medications used. Disease severity

was determined depending on their age of onset of symptoms,

clinical manifestations, and need of long-term prophylaxis.

Results: Sixty-five percent of the patients were female, the

mean age was 38.07±12.38 years, 93.3% were type 1 HAE, 58.3%

had a severe form of the disease, and 71.7% were under prophylaxis

with danazol. Fourteen patients were not using danazol regularly

due to the fear of side effects (n=11) and forgetfulness to take the

medication (n=4). It was observed that the patients who were the

only cases in their families, those having few relatives with HAE

and having had no excitus due to HAE in their families, were more

adherent to prophylactic treatment (P=0.008; P=0.018; P=0.028).

Conclusion: The majority of patients were effectively under

long-term prophylaxis and the majority adhered to this treatment.

The primary cause of non-adherence was fear of side effects.

Keywords

Adherence to treatment, Hereditary angioedema, Management, Long-term prophylaxis, Danazol, Side effects

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