Objective: Lower pregnancy rates have been reported in gonadotropin releasing hormone (GnRH) antagonist cycles in comparison to those with agonist cycles. A non-significant difference of 3.3% in the pregnancy rate per cycle in favour of GnRH agonists was found. The possible difference between these two protocols could be a limiting factor. We aim to determine if the embryos developed in long down-regulated assisted reproductive technology (ART) cycles differ from the ones obtained in antagonist cycles among women matched for age and follicle-stimulating hormone (FSH) administered on cycle day 3.
Patients and Methods: Retrospective cohort analysis was done on a population from a university affiliated hospital. 193 women undergoing standard in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment were included. The age and cycle day 3 FSH matched women undergoing either long or short protocols were compared. Group A consisted of women who had long down-regulation with GnRH analogues, group B consisted of women who had used GnRH antagonists. The clinical and ongoing pregnancy rates were compared. Day 3 embryo scores were compared between the groups.
Results: Although mean number of aspirated and inseminated oocytes were similar for the groups and average embryo scores were comparable, clinical and ongoing pregnancy rates were higher in group A than in group B. The percentage of embryos with zero fragmentation and 8-10 blastomeres on day 3 was similar in antagonist and long agonist cycles.
Conclusion: Long protocol ART cycles will result in comparable percentages of day 3 embryos with symmetric 8-10 blastomeres with zero fragmentation to those in antagonist cycles.
Keywords: Gonadotropin releasing hormone agonist, Gonadotropin releasing hormone antagonist, Pregnancy, Embryo score, Day 3 embryo
| Primary Language | en |
|---|---|
| Journal Section | Articles |
| Authors | |
| Dates |
Publication Date : September 14, 2015 |
| Bibtex | @ { marumj3173,
journal = {Marmara Medical Journal},
issn = {1019-1941},
eissn = {1309-9469},
address = {},
publisher = {Marmara University},
year = {2015},
volume = {28},
pages = {70 - 75},
doi = {10.5472/MMJra.2802.01},
title = {Does the quality of an embryo differ between long down-regulated and antagonist cycles among age and cycle day 3 FSH-matched women undergoing art?},
key = {cite},
author = {Yoldemi̇r, Tevfik}
} |
| APA | Yoldemi̇r, T . (2015). Does the quality of an embryo differ between long down-regulated and antagonist cycles among age and cycle day 3 FSH-matched women undergoing art? . Marmara Medical Journal , 28 (2) , 70-75 . DOI: 10.5472/MMJra.2802.01 |
| MLA | Yoldemi̇r, T . "Does the quality of an embryo differ between long down-regulated and antagonist cycles among age and cycle day 3 FSH-matched women undergoing art?" . Marmara Medical Journal 28 (2015 ): 70-75 <https://dergipark.org.tr/en/pub/marumj/issue/430/3173> |
| Chicago | Yoldemi̇r, T . "Does the quality of an embryo differ between long down-regulated and antagonist cycles among age and cycle day 3 FSH-matched women undergoing art?". Marmara Medical Journal 28 (2015 ): 70-75 |
| RIS | TY - JOUR T1 - Does the quality of an embryo differ between long down-regulated and antagonist cycles among age and cycle day 3 FSH-matched women undergoing art? AU - Tevfik Yoldemi̇r Y1 - 2015 PY - 2015 N1 - doi: 10.5472/MMJra.2802.01 DO - 10.5472/MMJra.2802.01 T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 70 EP - 75 VL - 28 IS - 2 SN - 1019-1941-1309-9469 M3 - doi: 10.5472/MMJra.2802.01 UR - https://doi.org/10.5472/MMJra.2802.01 Y2 - 2021 ER - |
| EndNote | %0 Marmara Medical Journal Does the quality of an embryo differ between long down-regulated and antagonist cycles among age and cycle day 3 FSH-matched women undergoing art? %A Tevfik Yoldemi̇r %T Does the quality of an embryo differ between long down-regulated and antagonist cycles among age and cycle day 3 FSH-matched women undergoing art? %D 2015 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 28 %N 2 %R doi: 10.5472/MMJra.2802.01 %U 10.5472/MMJra.2802.01 |
| ISNAD | Yoldemi̇r, Tevfik . "Does the quality of an embryo differ between long down-regulated and antagonist cycles among age and cycle day 3 FSH-matched women undergoing art?". Marmara Medical Journal 28 / 2 (September 2015): 70-75 . https://doi.org/10.5472/MMJra.2802.01 |
| AMA | Yoldemi̇r T . Does the quality of an embryo differ between long down-regulated and antagonist cycles among age and cycle day 3 FSH-matched women undergoing art?. Marmara Med J. 2015; 28(2): 70-75. |
| Vancouver | Yoldemi̇r T . Does the quality of an embryo differ between long down-regulated and antagonist cycles among age and cycle day 3 FSH-matched women undergoing art?. Marmara Medical Journal. 2015; 28(2): 70-75. |
| IEEE | T. Yoldemi̇r , "Does the quality of an embryo differ between long down-regulated and antagonist cycles among age and cycle day 3 FSH-matched women undergoing art?", Marmara Medical Journal, vol. 28, no. 2, pp. 70-75, Sep. 2015, doi:10.5472/MMJra.2802.01 |
