Year 2015, Volume 28 , Issue 2, Pages 112 - 115 2015-09-14

Leukoderma and chronic inflammatory demyelinating polyradiculoneuropathy in an adolescent with graft-versus-host disease

Gökhan OKAN [1] , Fatih ERBEY [2] , Mehmet Sait DURMUŞ [3] , Gülyüz Hanife ÖZTÜRK [4]


A 15-year-old Iraqi male patient with acute lymphoblastic leukemia received an allogeneic bone marrow transplant from his brother. On the 18th day after the transplant, the patient developed grade II acute graft-versus-host disease, and treatment included methylprednisolone. On day 140, the patient was diagnosed with leukoderma. On day 150, the patient was admitted to hospital because of numbness and muscle weakness in the extremities and a disturbance of the gait. Neurologic examination showed muscle weakness in the upper and lower extremities and there were no deep tendon reflexes. Nerve conduction studies showed reduced conduction speeds of the motor nerves with demyelinating features. The patient was diagnosed as having a chronic inflammatory demyelinating polyradiculoneuropathy (CIDB) based on clinical and electrophysiological findings. Treatment included methylprednisolone and intravenous immunoglobulin. The neurologic function improved but the skin lesions persisted.

This case shows that graft-versus-host disease can act as a triggering factor for the appearance of autoimmune diseases.

Keywords: Leukemia, Graft-versus-host disease, Leukoderma, Chronic inflammatory demyelinating polyneuropathy

  • BLANK NO CITATIONS
Primary Language en
Journal Section Case Reports
Authors

Author: Gökhan OKAN

Author: Fatih ERBEY

Author: Mehmet Sait DURMUŞ

Author: Gülyüz Hanife ÖZTÜRK

Dates

Publication Date : September 14, 2015

Bibtex @ { marumj3182, journal = {Marmara Medical Journal}, issn = {1019-1941}, eissn = {1309-9469}, address = {}, publisher = {Marmara University}, year = {2015}, volume = {28}, pages = {112 - 115}, doi = {10.5472/MMJcr.2802.10}, title = {Leukoderma and chronic inflammatory demyelinating polyradiculoneuropathy in an adolescent with graft-versus-host disease}, key = {cite}, author = {Okan, Gökhan and Erbey, Fatih and Durmuş, Mehmet Sait and Öztürk, Gülyüz Hanife} }
APA Okan, G , Erbey, F , Durmuş, M , Öztürk, G . (2015). Leukoderma and chronic inflammatory demyelinating polyradiculoneuropathy in an adolescent with graft-versus-host disease . Marmara Medical Journal , 28 (2) , 112-115 . DOI: 10.5472/MMJcr.2802.10
MLA Okan, G , Erbey, F , Durmuş, M , Öztürk, G . "Leukoderma and chronic inflammatory demyelinating polyradiculoneuropathy in an adolescent with graft-versus-host disease" . Marmara Medical Journal 28 (2015 ): 112-115 <https://dergipark.org.tr/en/pub/marumj/issue/430/3182>
Chicago Okan, G , Erbey, F , Durmuş, M , Öztürk, G . "Leukoderma and chronic inflammatory demyelinating polyradiculoneuropathy in an adolescent with graft-versus-host disease". Marmara Medical Journal 28 (2015 ): 112-115
RIS TY - JOUR T1 - Leukoderma and chronic inflammatory demyelinating polyradiculoneuropathy in an adolescent with graft-versus-host disease AU - Gökhan Okan , Fatih Erbey , Mehmet Sait Durmuş , Gülyüz Hanife Öztürk Y1 - 2015 PY - 2015 N1 - doi: 10.5472/MMJcr.2802.10 DO - 10.5472/MMJcr.2802.10 T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 112 EP - 115 VL - 28 IS - 2 SN - 1019-1941-1309-9469 M3 - doi: 10.5472/MMJcr.2802.10 UR - https://doi.org/10.5472/MMJcr.2802.10 Y2 - 2021 ER -
EndNote %0 Marmara Medical Journal Leukoderma and chronic inflammatory demyelinating polyradiculoneuropathy in an adolescent with graft-versus-host disease %A Gökhan Okan , Fatih Erbey , Mehmet Sait Durmuş , Gülyüz Hanife Öztürk %T Leukoderma and chronic inflammatory demyelinating polyradiculoneuropathy in an adolescent with graft-versus-host disease %D 2015 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 28 %N 2 %R doi: 10.5472/MMJcr.2802.10 %U 10.5472/MMJcr.2802.10
ISNAD Okan, Gökhan , Erbey, Fatih , Durmuş, Mehmet Sait , Öztürk, Gülyüz Hanife . "Leukoderma and chronic inflammatory demyelinating polyradiculoneuropathy in an adolescent with graft-versus-host disease". Marmara Medical Journal 28 / 2 (September 2015): 112-115 . https://doi.org/10.5472/MMJcr.2802.10
AMA Okan G , Erbey F , Durmuş M , Öztürk G . Leukoderma and chronic inflammatory demyelinating polyradiculoneuropathy in an adolescent with graft-versus-host disease. Marmara Med J. 2015; 28(2): 112-115.
Vancouver Okan G , Erbey F , Durmuş M , Öztürk G . Leukoderma and chronic inflammatory demyelinating polyradiculoneuropathy in an adolescent with graft-versus-host disease. Marmara Medical Journal. 2015; 28(2): 112-115.
IEEE G. Okan , F. Erbey , M. Durmuş and G. Öztürk , "Leukoderma and chronic inflammatory demyelinating polyradiculoneuropathy in an adolescent with graft-versus-host disease", Marmara Medical Journal, vol. 28, no. 2, pp. 112-115, Sep. 2015, doi:10.5472/MMJcr.2802.10