Abstract
Objectives: Various levels of dysfunction and damage can occur in the central nervous system of patients experiencing seizures. It is known that these impairments can be assessed by measurement of biochemical markers. S100B proteins have been extensively studied in recent years. We have assessed whether there is a change in serum S100B protein levels during seizures which lead to cerebral hypoperfusion and/or hypoxia.Patients and Methods: A total of 56 patients admitted to an emergency service due to seizures and more than 18 years of age were included in the study. The control group consisted of 20 patients who were admitted to the emergency service due to complaints other than seizures. Results: There was a significant difference between the groups in terms of gender, hemoglobin levels and S100B levels, whereas there was no significant difference in terms of glucose, sodium and potassium levels. The S100B levels were significantly lower in the patient group compared to the control group. Hemoglobin levels was significantly lower in the control group compared to the patient group.Conclusion: Serum S100B protein concentration was found to be significantly lower in patients compared to controls
Keywords
References
- 1. Engel J Jr. International League Against Epilepsy (ILAE). A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001; 42:796-803.x doi: 10.1046/j.1528-1157.2001.10401.x
- 2. ACEP Clinical Policies Committee. Clinical Policies Subcommittee on Seizures. Clinical policy: Critical issues in the evaluation and management of adult patients presenting to the emergency department with seizures. Ann Emerg Med 2004; 43:605-25.doi:10.1016/j. annemergmed.2004.01.017
- 3. Donato R. Intracellular and extracellular roles of S100 proteins. Microsc Res Tech 2003; 60:540-51. doi: 10.1002/jemt.10296.
- 4. Rothermundt M, Peters M, Prehn JH, et al. S100B in brain damage and neurodegeneration. Microsc Res Tech 2003; 60:614-32. doi: 10.1002/ jemt.10303
- 5. Donato R, Sorci G, Riuzzi F, et al.S100B’ s double life: Intracellular regulator and extracellular signal. Biochim Biophys Acta 2009;1008- 22. doi: 10.1016/j.bbamcr.2008.11.009.
- 6. Adami C, Sorci G, Blasi E, et al. S100B expression in and effects on microglia. Glia 2001; 33:131-42. .doi:10.1002/1098- 1136(200102)33:2<131::AID-GLIA1012>3.3.CO;2-4
- 7. Pinto SS, Gottfried C, Mendez A, et al. Immunocontent and secretion of S100B in astrocyte cultures from different brain regions in relation to morphology. FEBS Lett 2000; 486:203-7. doi:10.1016/S0014- 5793(00)02301-2
- 8. Kleindienst A, Ross Bullock M. A critical analysis of the role of the neurotrophic protein S100B in acute brain injury. J Neurotrauma 2006; 23:1185-200. doi:10.1089/neu.2006.23.1185
- 9. Delgado P, Alvarez Sabin J, Santamarina E, et al. Plasma S100B level after acute spontaneous intracerebral hemorrhage. Stroke 2006; 37:2837-9. doi:10.1161/01.STR.0000245085.58807.ad
- 10. Wunderlich MT, Ebert AD, Kratz T, et al. Early neurobehavioral outcome after stroke is related to release of neurobiochemical markers of brain damage. Stroke 1999; 30:1190-5. doi: 10.1161/01. STR.30.6.1190
- 11. Sakatani S, Seto-Ohshima A, Shinohara Y, et al. Neural-activitydependent release of S100B from astrocytes enhances kainate-induces gamma oscillations in vivo. 2008; 22:28:10928-36. doi:10.1523/ JNEUROSCI.3693-08.2008
- 12. Oses JP, Leke R, Portela LV, et al. Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol. Brain Res Bull 2004; 64:237-42. doi: 10.1016/j. brainresbull.2004.07.006
- 13. Otto M, Wiltfang J, Mogge S,and et al. Changing levels of S100 protein in serum after epileptic seizures. Epilepsia 1998; (suppl)39:73
- 14. Palmio J, Peltola J, Vuorinen P, et al. Normal CSF neuron-specific enolase and S-100 protein levels in patients with recent noncomplicated tonic-clonic seizures. J Neurol Sci 2001; 183:27-31. doi:10.1016/S0022-510X(00)00478.0
- 15. Büttner T, Lack B, Jäger M, et al. Serum levels of neuron-specific enolase and s-100 protein after single tonic-clonic seizures. J Neurol 1999; 246:459-61.
- 16. Leutmezer F, Wagner O, Baumgartner C. Serum s-100 protein is not a suitable seizure marker in temporal lobe epilepsy. Epilepsia 2002; 43:1172-4. doi: 10.1046/j.1528-1157.2002.50101.x
- 17. Palmio J, Keranen T, Alapirtti T, et al. Elevated serum neuron-specific enolase in patients with temporal lobe epilepsy: a video-EEG study. Epilepsy Res 2008; 81:155-60.
- 18. Calik M, Abuhandan M, Sönmezler, et al. Elevated serum S100B levels in children with temporal lobe epilepy. Seizure 2013; 22: 99- 102. doi: 10.1016/ j.seizure.2012.10.012
- 19. Atıcı Y, Alehan F, Sezer T, et al. Serum s100B levels in children with simple febrile seizures. Seizure 2012; 21: 175-7. doi: 10.1016/j. seizure.2011.11.003.
- 20. Mikkonen K, Pekkala N, Pokka T, et al. S100B proteins in febrile seizures. Seizure. 2012; 21: 144-6. doi:10.1016/j.seizure.2011.10.006.
- 21. Dyck RH, Bogoch II, Marks A, et al.Enhanced epileptogenesis in S100B knockout mice. Brain Res Mol Brain Res 2002; 106:22-9. doi: 10.1016/S0169-328X(02)00406-0.
- 22. Portela LV, Tort AB, Schaf DV, et al. The serum S100B concentration is age dependent. Clin Chem 2002; 48:950-2.
- 23. Bharucha NE, Bharucha EP, Bharucha AE, et al. Prevalence of epilepsy in the Parsi community of Bombay. Epilepsia 1988; 29:111-5. doi:10.1111/j.1528-1157.1988.tb04405.x
Abstract
Amaç: Nöbet geçiren hastalarda santral sinir sisteminde farklı düzeylerde disfonksiyon ve hasar oluşabilmektedir. Bu hasarlanmaların biyokimyasal belirteçlere bakılmak suretiyle değerlendirilebileceği bilinmektedir. Son yıllarda giderek artan bir şekilde “beyine özel göstergeler” araştırılmaktadır. Bu çalışmada serebral hipoperfüzyon ve/veya hipoksiye neden olan nöbet durumlarında serum S100B protein düzeylerinde değişiklik oluşup oluşmadığının belirlenmesi amaçlanmıştır. Hastalar ve Yöntem: Acil servise nöbet şikayetiyle başvuran ≥18 yaşında 56 hasta çalışmaya alınmıştır. Kontrol grubunu nöbet dışı bir şikayetle acil servise başvuran 20 hasta oluşturmuştur. Bulgular: Gruplar arasında cinsiyet, hemoglobin değerleri ve S100B proteini açısından anlamlı olarak fark bulunmuştur. Bunun yanında glukoz, sodyum ve potasyum değerleri açısından gruplar arasında anlamlı olarak bir fark yoktur. Hasta grubu S100B değerleri, kontrol grubuna göre istatistiksel açıdan anlamlı olarak düşük bulunmuştur. Hemoglobin değerleri ise, kontrol grubunda, hasta grubuna göre anlamlı olarak düşük bulunmuştur. Sonuç: Hasta grubu serum S100B protein konsantrasyonu, kontrol grubundan anlamlı olarak düşük bulunmuştur.
Keywords
References
- 1. Engel J Jr. International League Against Epilepsy (ILAE). A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001; 42:796-803.x doi: 10.1046/j.1528-1157.2001.10401.x
- 2. ACEP Clinical Policies Committee. Clinical Policies Subcommittee on Seizures. Clinical policy: Critical issues in the evaluation and management of adult patients presenting to the emergency department with seizures. Ann Emerg Med 2004; 43:605-25.doi:10.1016/j. annemergmed.2004.01.017
- 3. Donato R. Intracellular and extracellular roles of S100 proteins. Microsc Res Tech 2003; 60:540-51. doi: 10.1002/jemt.10296.
- 4. Rothermundt M, Peters M, Prehn JH, et al. S100B in brain damage and neurodegeneration. Microsc Res Tech 2003; 60:614-32. doi: 10.1002/ jemt.10303
- 5. Donato R, Sorci G, Riuzzi F, et al.S100B’ s double life: Intracellular regulator and extracellular signal. Biochim Biophys Acta 2009;1008- 22. doi: 10.1016/j.bbamcr.2008.11.009.
- 6. Adami C, Sorci G, Blasi E, et al. S100B expression in and effects on microglia. Glia 2001; 33:131-42. .doi:10.1002/1098- 1136(200102)33:2<131::AID-GLIA1012>3.3.CO;2-4
- 7. Pinto SS, Gottfried C, Mendez A, et al. Immunocontent and secretion of S100B in astrocyte cultures from different brain regions in relation to morphology. FEBS Lett 2000; 486:203-7. doi:10.1016/S0014- 5793(00)02301-2
- 8. Kleindienst A, Ross Bullock M. A critical analysis of the role of the neurotrophic protein S100B in acute brain injury. J Neurotrauma 2006; 23:1185-200. doi:10.1089/neu.2006.23.1185
- 9. Delgado P, Alvarez Sabin J, Santamarina E, et al. Plasma S100B level after acute spontaneous intracerebral hemorrhage. Stroke 2006; 37:2837-9. doi:10.1161/01.STR.0000245085.58807.ad
- 10. Wunderlich MT, Ebert AD, Kratz T, et al. Early neurobehavioral outcome after stroke is related to release of neurobiochemical markers of brain damage. Stroke 1999; 30:1190-5. doi: 10.1161/01. STR.30.6.1190
- 11. Sakatani S, Seto-Ohshima A, Shinohara Y, et al. Neural-activitydependent release of S100B from astrocytes enhances kainate-induces gamma oscillations in vivo. 2008; 22:28:10928-36. doi:10.1523/ JNEUROSCI.3693-08.2008
- 12. Oses JP, Leke R, Portela LV, et al. Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol. Brain Res Bull 2004; 64:237-42. doi: 10.1016/j. brainresbull.2004.07.006
- 13. Otto M, Wiltfang J, Mogge S,and et al. Changing levels of S100 protein in serum after epileptic seizures. Epilepsia 1998; (suppl)39:73
- 14. Palmio J, Peltola J, Vuorinen P, et al. Normal CSF neuron-specific enolase and S-100 protein levels in patients with recent noncomplicated tonic-clonic seizures. J Neurol Sci 2001; 183:27-31. doi:10.1016/S0022-510X(00)00478.0
- 15. Büttner T, Lack B, Jäger M, et al. Serum levels of neuron-specific enolase and s-100 protein after single tonic-clonic seizures. J Neurol 1999; 246:459-61.
- 16. Leutmezer F, Wagner O, Baumgartner C. Serum s-100 protein is not a suitable seizure marker in temporal lobe epilepsy. Epilepsia 2002; 43:1172-4. doi: 10.1046/j.1528-1157.2002.50101.x
- 17. Palmio J, Keranen T, Alapirtti T, et al. Elevated serum neuron-specific enolase in patients with temporal lobe epilepsy: a video-EEG study. Epilepsy Res 2008; 81:155-60.
- 18. Calik M, Abuhandan M, Sönmezler, et al. Elevated serum S100B levels in children with temporal lobe epilepy. Seizure 2013; 22: 99- 102. doi: 10.1016/ j.seizure.2012.10.012
- 19. Atıcı Y, Alehan F, Sezer T, et al. Serum s100B levels in children with simple febrile seizures. Seizure 2012; 21: 175-7. doi: 10.1016/j. seizure.2011.11.003.
- 20. Mikkonen K, Pekkala N, Pokka T, et al. S100B proteins in febrile seizures. Seizure. 2012; 21: 144-6. doi:10.1016/j.seizure.2011.10.006.
- 21. Dyck RH, Bogoch II, Marks A, et al.Enhanced epileptogenesis in S100B knockout mice. Brain Res Mol Brain Res 2002; 106:22-9. doi: 10.1016/S0169-328X(02)00406-0.
- 22. Portela LV, Tort AB, Schaf DV, et al. The serum S100B concentration is age dependent. Clin Chem 2002; 48:950-2.
- 23. Bharucha NE, Bharucha EP, Bharucha AE, et al. Prevalence of epilepsy in the Parsi community of Bombay. Epilepsia 1988; 29:111-5. doi:10.1111/j.1528-1157.1988.tb04405.x
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | October 1, 2015 |
| Published in Issue | Year 2013 Volume: 26 Issue: 2 |