Year 2020, Volume 33 , Issue 2, Pages 83 - 89 2020-05-31

The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas

Muhammed Hasan TOPER [1] , Suheyla BOZKURT [2] , Tayfun ELIBOL [3] , Tulin TUGLULAR [4]


Objective: The cases of diffuse large B-cell lymphoma, (DLBCL not otherwise specified (NOS)) which immunohistochemically
exhibit MYC and BCL2 expressions are defined as double-expressor lymphomas (DELs). This study aimed to assess the prognostic
impact of DEL and the expressions of other proteins that may have role in tumorogenesis.
Materials and Methods: In this study, 90 tumor samples from patients diagnosed with DLBCL NOS were evaluated retrospectively.
Immunoexpressions of MYC, BCL2, activation-induced cytidine deaminase (AID), uracil-DNA glycosylase (UNG) and DNA
mismatch repair proteins including MLH1, MSH2, MSH6 and PMS2 were analyzed.
Result: Eleven cases (12.2%) which exhibited ≥40% MYC and ≥50% BCL2 immunexpressions were classified as DEL DLBCL. Patients
with MYC positivity displayed lower overall survival rate than MYC negative cases. A trend of lower overall survival was observed in
the double-expressor lymphoma group, however, this was not proven to be statistically significant. Significant relationship between
AID, UNG and p53 immunexpressions with double-expressor lymphoma or overall survival was not detected. The correlation
between immunexpressions of p53 and MYC was observed. The loss of expression of mismatch repair proteins was not observed in
any cases.
Conclusion: In this study, a relationship between low overall survival and MYC expression is detected. However, our result does not
demonstrate that double-expressor lymphoma can be associated with poor outcomes.
Diffuse large B-cell lymphoma, Double-expressor lymphoma, MYC, BCL2, AID, Mismatch repair proteins
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Primary Language en
Subjects Medicine
Journal Section Original Research
Authors

Author: Muhammed Hasan TOPER (Primary Author)
Institution: DOKUZ EYLUL UNIVERSITY
Country: Turkey


Author: Suheyla BOZKURT
Institution: Marmara University
Country: Turkey


Author: Tayfun ELIBOL
Institution: Marmara University
Country: Turkey


Author: Tulin TUGLULAR
Institution: Marmara University
Country: Turkey


Dates

Publication Date : May 31, 2020

Bibtex @research article { marumj741651, journal = {Marmara Medical Journal}, issn = {1019-1941}, eissn = {1309-9469}, address = {}, publisher = {Marmara University}, year = {2020}, volume = {33}, pages = {83 - 89}, doi = {10.5472/marumj.741651}, title = {The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas}, key = {cite}, author = {Toper, Muhammed Hasan and Bozkurt, Suheyla and Elıbol, Tayfun and Tuglular, Tulin} }
APA Toper, M , Bozkurt, S , Elıbol, T , Tuglular, T . (2020). The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas. Marmara Medical Journal , 33 (2) , 83-89 . DOI: 10.5472/marumj.741651
MLA Toper, M , Bozkurt, S , Elıbol, T , Tuglular, T . "The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas". Marmara Medical Journal 33 (2020 ): 83-89 <https://dergipark.org.tr/en/pub/marumj/issue/54613/741651>
Chicago Toper, M , Bozkurt, S , Elıbol, T , Tuglular, T . "The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas". Marmara Medical Journal 33 (2020 ): 83-89
RIS TY - JOUR T1 - The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas AU - Muhammed Hasan Toper , Suheyla Bozkurt , Tayfun Elıbol , Tulin Tuglular Y1 - 2020 PY - 2020 N1 - doi: 10.5472/marumj.741651 DO - 10.5472/marumj.741651 T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 83 EP - 89 VL - 33 IS - 2 SN - 1019-1941-1309-9469 M3 - doi: 10.5472/marumj.741651 UR - https://doi.org/10.5472/marumj.741651 Y2 - 2020 ER -
EndNote %0 Marmara Medical Journal The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas %A Muhammed Hasan Toper , Suheyla Bozkurt , Tayfun Elıbol , Tulin Tuglular %T The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas %D 2020 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 33 %N 2 %R doi: 10.5472/marumj.741651 %U 10.5472/marumj.741651
ISNAD Toper, Muhammed Hasan , Bozkurt, Suheyla , Elıbol, Tayfun , Tuglular, Tulin . "The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas". Marmara Medical Journal 33 / 2 (May 2020): 83-89 . https://doi.org/10.5472/marumj.741651
AMA Toper M , Bozkurt S , Elıbol T , Tuglular T . The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas. Marmara Med J. 2020; 33(2): 83-89.
Vancouver Toper M , Bozkurt S , Elıbol T , Tuglular T . The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas. Marmara Medical Journal. 2020; 33(2): 89-83.