Year 2020, Volume 33 , Issue 2, Pages 97 - 101 2020-05-31

The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study

Ozge YAPICI UGURLAR [1] , Mehmet Sait BUGDAYCI [2] , Abdullah Soydan MAHMUTOGLU [3] , Canan ALKIM [4] , Banu YILMAZ OZGUVEN [5] , Alper OZEL [6] , Muzaffer BASAK [7] , Yasin AYKUT [8] , Huseyin OZKURT [9] , Sukru Mehmet ERTURK [10]


Objective: To evaluate the role of magnetic resonance (MR) diffusion tensor imaging (DTI) in the assessment of liver fibrosis and
inflammation in chronic viral hepatitis by measuring apparent diffusion coefficient (ADC) and fractional anisotropy (Fa) values.
Material and Methods: Twenty-seven patients (5 women and 22 men;mean age39.8±11.3) with hepatic fibrosis were included in
our study. The relationship between ADC, Fa values and histological activity index (HAI) score were evaluated using Spearman’s
correlation coefficient. Patients were subgrouped as group A (fibrosis score 1) and group B (fibrosis score 3). The mean ADC and Fa
values of groups A and B were compared using Student’s t-test. To evaluate the use of ADC and Fa values in distinguishing group A
from group B, ROC analysis was applied; sensitivities and specificities were calculated.
Results: Fa values correlated with HAI scores significantly (r=0.397, p<0.05) The difference was significant between the mean ADC
values (group A:1.46± 0.191x103mm2/s; group B:1.105± 0.141x10-3 mm2/s; p<0.001) and Fa values (group A: 0.473±0.091; group
B: 0.643± 0.007; p<0.001) between the groups. For distinguishing group A from group B, ADC had a sensitivity of 81.8% and a
specificity of 93.8%. The sensitivity and specificity of Fa were 90.9% and 100%, respectively.
Conclusion: Diffusion tensor imaging may play a role in the evaluation of fibrosis and HAI scores in patients with liver fibrosis.
Hepatitis, Liver fibrosis, Diffusion tensor imaging
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Primary Language en
Subjects Medicine
Journal Section Original Research
Authors

Author: Ozge YAPICI UGURLAR
Institution: ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL
Country: Turkey


Author: Mehmet Sait BUGDAYCI
Institution: ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL
Country: Turkey


Author: Abdullah Soydan MAHMUTOGLU
Institution: ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL
Country: Turkey


Author: Canan ALKIM
Institution: ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL
Country: Turkey


Author: Banu YILMAZ OZGUVEN
Institution: ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL
Country: Turkey


Author: Alper OZEL
Institution: ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL
Country: Turkey


Author: Muzaffer BASAK
Institution: ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL
Country: Turkey


Author: Yasin AYKUT
Institution: ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL
Country: Turkey


Author: Huseyin OZKURT
Institution: ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL
Country: Turkey


Author: Sukru Mehmet ERTURK (Primary Author)
Institution: ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL
Country: Turkey


Dates

Publication Date : May 31, 2020

Bibtex @research article { marumj741724, journal = {Marmara Medical Journal}, issn = {1019-1941}, eissn = {1309-9469}, address = {}, publisher = {Marmara University}, year = {2020}, volume = {33}, pages = {97 - 101}, doi = {10.5472/marumj.741724}, title = {The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study}, key = {cite}, author = {Yapıcı Ugurlar, Ozge and Bugdaycı, Mehmet Sait and Mahmutoglu, Abdullah Soydan and Alkım, Canan and Yılmaz Ozguven, Banu and Ozel, Alper and Basak, Muzaffer and Aykut, Yasin and Ozkurt, Huseyin and Erturk, Sukru Mehmet} }
APA Yapıcı Ugurlar, O , Bugdaycı, M , Mahmutoglu, A , Alkım, C , Yılmaz Ozguven, B , Ozel, A , Basak, M , Aykut, Y , Ozkurt, H , Erturk, S . (2020). The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study. Marmara Medical Journal , 33 (2) , 97-101 . DOI: 10.5472/marumj.741724
MLA Yapıcı Ugurlar, O , Bugdaycı, M , Mahmutoglu, A , Alkım, C , Yılmaz Ozguven, B , Ozel, A , Basak, M , Aykut, Y , Ozkurt, H , Erturk, S . "The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study". Marmara Medical Journal 33 (2020 ): 97-101 <https://dergipark.org.tr/en/pub/marumj/issue/54613/741724>
Chicago Yapıcı Ugurlar, O , Bugdaycı, M , Mahmutoglu, A , Alkım, C , Yılmaz Ozguven, B , Ozel, A , Basak, M , Aykut, Y , Ozkurt, H , Erturk, S . "The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study". Marmara Medical Journal 33 (2020 ): 97-101
RIS TY - JOUR T1 - The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study AU - Ozge Yapıcı Ugurlar , Mehmet Sait Bugdaycı , Abdullah Soydan Mahmutoglu , Canan Alkım , Banu Yılmaz Ozguven , Alper Ozel , Muzaffer Basak , Yasin Aykut , Huseyin Ozkurt , Sukru Mehmet Erturk Y1 - 2020 PY - 2020 N1 - doi: 10.5472/marumj.741724 DO - 10.5472/marumj.741724 T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 97 EP - 101 VL - 33 IS - 2 SN - 1019-1941-1309-9469 M3 - doi: 10.5472/marumj.741724 UR - https://doi.org/10.5472/marumj.741724 Y2 - 2020 ER -
EndNote %0 Marmara Medical Journal The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study %A Ozge Yapıcı Ugurlar , Mehmet Sait Bugdaycı , Abdullah Soydan Mahmutoglu , Canan Alkım , Banu Yılmaz Ozguven , Alper Ozel , Muzaffer Basak , Yasin Aykut , Huseyin Ozkurt , Sukru Mehmet Erturk %T The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study %D 2020 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 33 %N 2 %R doi: 10.5472/marumj.741724 %U 10.5472/marumj.741724
ISNAD Yapıcı Ugurlar, Ozge , Bugdaycı, Mehmet Sait , Mahmutoglu, Abdullah Soydan , Alkım, Canan , Yılmaz Ozguven, Banu , Ozel, Alper , Basak, Muzaffer , Aykut, Yasin , Ozkurt, Huseyin , Erturk, Sukru Mehmet . "The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study". Marmara Medical Journal 33 / 2 (May 2020): 97-101 . https://doi.org/10.5472/marumj.741724
AMA Yapıcı Ugurlar O , Bugdaycı M , Mahmutoglu A , Alkım C , Yılmaz Ozguven B , Ozel A , Basak M , Aykut Y , Ozkurt H , Erturk S . The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study. Marmara Med J. 2020; 33(2): 97-101.
Vancouver Yapıcı Ugurlar O , Bugdaycı M , Mahmutoglu A , Alkım C , Yılmaz Ozguven B , Ozel A , Basak M , Aykut Y , Ozkurt H , Erturk S . The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study. Marmara Medical Journal. 2020; 33(2): 101-97.

Authors of the Article
Ozge YAPICI UGURLAR [1]
Mehmet Sait BUGDAYCI [2]
Abdullah Soydan MAHMUTOGLU [3]
Canan ALKIM [4]
Banu YILMAZ OZGUVEN [5]
Alper OZEL [6]
Muzaffer BASAK [7]
Yasin AYKUT [8]
Huseyin OZKURT [9]
Sukru Mehmet ERTURK [10]