Year 2020, Volume 33 , Issue 3, Pages 133 - 140 2020-10-23

Antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts

Melis SUMENGEN OZDENEFE [1] , Feryal TANOGLU [2] , Kaya SUER [3] , Emrah GULER [4] , Hatice Aysun MERCIMEK TAKCI [5]


Objective: The aim of this study was to determine the antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts obtained from the Turkish Republic of Northern Cyprus. Materials and Methods: Fruits and leaves of F. sycomorus were collected from the Kyrenia region of Northern Cyprus in July 2018. The leaf and fruit samples were extracted with the distilled water, methanol, ethanol, acetone and chloroform solvents (1:10 [w/v]). After evaporation, samples were suspended in methanol at the final concentration of 100 mg/mL. The antimicrobial activity of the leaf and fruit extracts was evaluated using the Kirby-Bauer Disk Diffusion Method. Total phenolic content (TPC) and total flavonoid content (TFC) of the extracts were determined using the methods reported by Stankovic in 2011 and Sharm and Vig in 2013. Antioxidant activity of samples was tested using free radical scavenger method. Results: The leaf extracts of F. sycomorus was active. The inhibition zone diameters ranged from 1.8mm to 13.00 mm. Fruit extracts and methanol controls showed no inhibitory effect on strains. However, bacteriostatic activity against Enterococcus faecalis was observed in fruit-water extract. The highest antimicrobial activity was shown against Staphylococcus aureus (13 mm) for ethanolic extracts at 100 mg/mL concentration. Minimal inhibition concentration (MIC) for ethanolic extract was observed starting at 25 mg/mL concentration against S. aureus. Although, no antimicrobial activiy was observed in fruit extracts, the highest 2,2-diphenyl 1-picrylhydrazyl (DPPH) activiy and phytochemical content were recorded in fruit extracts. Conclusion: These results demonstrate that leaf extracts of F. sycomorus can be used as a curative agent for the treatment of S. aureus and fungal infections and may be effective against pathogenic microorganisms that are resistant to antibiotics. Antioxidant content of fruit and leaf extracts can be effective against the negative effects of free radicals.
Antioxidant activity, F. sycomorus, S. aureus
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Primary Language en
Subjects Medicine
Journal Section Articles
Authors

Orcid: 0000-0003-0804-9557
Author: Melis SUMENGEN OZDENEFE
Institution: NEAR EAST UNIVERSITY
Country: Turkey


Orcid: 0000-0002-2824-2330
Author: Feryal TANOGLU
Institution: NEAR EAST UNIVERSITY
Country: Turkey


Orcid: 0000-0002-2565-3425
Author: Kaya SUER
Institution: NEAR EAST UNIVERSITY
Country: Turkey


Orcid: 0000-0002-1635-0051
Author: Emrah GULER
Institution: NEAR EAST UNIVERSITY
Country: Turkey


Orcid: 0000-0002-3388-1153
Author: Hatice Aysun MERCIMEK TAKCI
Institution: KİLİS 7 ARALIK ÜNİVERSİTESİ
Country: Turkey


Dates

Publication Date : October 23, 2020

Bibtex @research article { marumj816301, journal = {Marmara Medical Journal}, issn = {1019-1941}, eissn = {1309-9469}, address = {}, publisher = {Marmara University}, year = {2020}, volume = {33}, pages = {133 - 140}, doi = {10.5472/marumj.816301}, title = {Antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts}, key = {cite}, author = {Sumengen Ozdenefe, Melis and Tanoglu, Feryal and Suer, Kaya and Guler, Emrah and Mercımek Takcı, Hatice Aysun} }
APA Sumengen Ozdenefe, M , Tanoglu, F , Suer, K , Guler, E , Mercımek Takcı, H . (2020). Antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts . Marmara Medical Journal , 33 (3) , 133-140 . DOI: 10.5472/marumj.816301
MLA Sumengen Ozdenefe, M , Tanoglu, F , Suer, K , Guler, E , Mercımek Takcı, H . "Antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts" . Marmara Medical Journal 33 (2020 ): 133-140 <https://dergipark.org.tr/en/pub/marumj/issue/57487/816301>
Chicago Sumengen Ozdenefe, M , Tanoglu, F , Suer, K , Guler, E , Mercımek Takcı, H . "Antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts". Marmara Medical Journal 33 (2020 ): 133-140
RIS TY - JOUR T1 - Antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts AU - Melis Sumengen Ozdenefe , Feryal Tanoglu , Kaya Suer , Emrah Guler , Hatice Aysun Mercımek Takcı Y1 - 2020 PY - 2020 N1 - doi: 10.5472/marumj.816301 DO - 10.5472/marumj.816301 T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 133 EP - 140 VL - 33 IS - 3 SN - 1019-1941-1309-9469 M3 - doi: 10.5472/marumj.816301 UR - https://doi.org/10.5472/marumj.816301 Y2 - 2020 ER -
EndNote %0 Marmara Medical Journal Antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts %A Melis Sumengen Ozdenefe , Feryal Tanoglu , Kaya Suer , Emrah Guler , Hatice Aysun Mercımek Takcı %T Antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts %D 2020 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 33 %N 3 %R doi: 10.5472/marumj.816301 %U 10.5472/marumj.816301
ISNAD Sumengen Ozdenefe, Melis , Tanoglu, Feryal , Suer, Kaya , Guler, Emrah , Mercımek Takcı, Hatice Aysun . "Antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts". Marmara Medical Journal 33 / 3 (October 2020): 133-140 . https://doi.org/10.5472/marumj.816301
AMA Sumengen Ozdenefe M , Tanoglu F , Suer K , Guler E , Mercımek Takcı H . Antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts. Marmara Med J. 2020; 33(3): 133-140.
Vancouver Sumengen Ozdenefe M , Tanoglu F , Suer K , Guler E , Mercımek Takcı H . Antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts. Marmara Medical Journal. 2020; 33(3): 133-140.
IEEE M. Sumengen Ozdenefe , F. Tanoglu , K. Suer , E. Guler and H. Mercımek Takcı , "Antioxidant and antimicrobial activity of Ficus sycomorus fruit and leaf extracts", Marmara Medical Journal, vol. 33, no. 3, pp. 133-140, Oct. 2020, doi:10.5472/marumj.816301