Clinical and biochemical characteristics of Sjögren’s syndrome and its differences from keratoconjunctivitis sicca

Year 2021, Volume: 34 Issue: 2, 208 - 214, 31.05.2021

Ismail Taskıran Umut Kalyoncu Sedat Kıraz

https://doi.org/10.5472/marumj.944279

Abstract

Objective: In this study we aimed to compare the clinical and biochemical characteristics of primary Sjögren’s syndrome patients with
that of keratoconjunctivitis sicca, secondary Sjögren syndrome and undifferentiated disease.
Patients and Methods: Patients with Sjögren’s syndrome and keratoconjunctivitis sicca who applied between August 2009 and January
2010 were included in this study. Demographic data, laboratory characteristics, Schirmer’s test and salivary gland biopsies of the
patients were recorded.
Results: Average diagnosis age for 87 primary Sjögren’s syndrome, 25 secondary Sjögren’s syndrome, 27 keratoconjunctivitis sicca and
44 undifferentiated group patients were 45±13, 43±14, 44±11 ve 45±11 years (p>0.05), accordingly. Critical and severe mouth dryness
rate was 45% in primary Sjögren’s syndrome group and 7% in keratoconjunctivitis sicca group, critical and severe eye dryness was 43%
in primary Sjögren’s syndrome group and 78% in keratoconjunctivitis sicca group (p<0.001). Grade 3≥ positivity in salivary gland
biopsy was found as 71.2% in primary Sjögren’s syndrome group and 27.2% in the undifferentiated group (p<0.001).
Conclusions: More dense lymphocyte infiltration was detected in primary Sjögren’s syndrome in salivary gland biopsies. As 27.2% of
undifferentiated group patients had positive salivary gland biopsies, they might need follow-ups in terms of having increased risk of
developing primary Sjögren’s syndrome.

Keywords

Keratoconjuctivitis sicca, Schirmer’s test, Sjögren’s syndrome

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