The effect of performance score, prognostic nutritional index, serum neutrophil-to-lymphocyte ratio, and thrombocyte-to-lymphocyte ratio on prognosis in non-small cell lung cancer

Year 2022, Volume: 35 Issue: 1, 94 - 99, 31.01.2022

Tibel Tuna Yasemin Kemal Yusuf Taha Gullu Nurhan Koksal Selen Ala

https://doi.org/10.5472/marumj.1065820

Abstract

Objective: Systemic inflammatory markers and nutritional status of the patients can be helpful both in identifying high-risk cancer
patients and in showing the prognosis of the disease. In this study we aimed to determine the effects of nutritional status and systemic
inflammatory markers on prognosis in non-small cell lung cancer.
Patients and Methods: Patients diagnosed with lung cancer between 2015 and 2019 were analyzed retrospectively. The prognostic
nutritional index (PNI), platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio(NLR) were calculated and Eastern
Cooperative Oncology Group performance status (ECOG PS), and the dates of death or last follow-up were recorded. Cox regression
analysis and Kaplan-Meier curves were used to analyze the effects of parameters on survival.
Results: In the study, a total of 219 patients were analyzed. 85.4% of the patients had died. At the third step Cox regression model,
ECOG 3-4 (HR:2.18), PLR (HR:1.20) and PNI (HR:1.12) predicted the survival times. Patients with PNI>45 had a higher median
survival (495 days) than patients with PNI<45 (314 days).
Conclusion: In order to determine the prognosis of the patients at the time of diagnosis, it is recommended to use PNI and PLR values,
which can be obtained through repeated tests and evaluated at low cost, together with performance scores.

Keywords

Lung cancer, Inflammation, Nutritional status

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