The role of procalcitonin as a biomarker for acute pulmonary exacerbation in subjects with cystic fibrosis and non-cystic fibrosis bronchiectasis

Year 2022, Volume: 35 Issue: 2, 164 - 171, 30.05.2022

Firuz Mammadov Sehnaz Olgun Yıldızelı Derya Kocakaya Huseyin Arıkan Caner Çınar Emel Eryuksel Berrin Ceyhan

https://doi.org/10.5472/marumj.1114952

Cited By: 1

Abstract

Objective: Patients with cystic fibrosis (CF) and non-CF bronchiectasis are prone to exacerbations of pulmonary infections. C-reactive
protein (CRP) and procalcitonin (PCT) are inflammatory markers. The aim of this study is to evaluate the role of CRP and PCT on
exacerbations of CF and non-CF bronchiectasis.

Patients and Methods: The medical records of 18 CF (52 hospitalizations) and 20 non-CF bronchiectasis patients (51 hospitalizations)
were reviewed retrospectively. CRP, PCT levels and, white blood cell (WBC) counts on admission and follow-up were evaluated.

Results: C-reactive protein levels correlated with PCT levels on admission in all patients. Baseline PCT levels were markedly higher
(>0.5µg/L) in 12% of CF and 10% of non-CF bronchiectasis patients, however, baseline CRP values were markedly higher (>5mg/L)
in 96% of CF and non-CF bronchiectasis patients (p=0.760 and p=0.100, respectively). Baseline CRP and PCT levels were positively
correlated with hospitalization length (r=0.501, p=0.001 and r=0.289, p=0.04, respectively) in CF patients, but not in non-CF
bronchiectasis.

Conclusion: Our study shows the potential utility of these biomarkers to determine the severity of the exacerbation particularly
predicting hospitalization length in CF patients. Both biomarkers could be able to guide antibiotic treatment of infective exacerbations
in CF and non-CF bronchiectasis patients

Keywords

Cystic fibrosis, Bronchiectasis, Exacerbation, Infection, Procalcitonin, C-reactive protein

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