Increased D-dimer is associated with disease progression and increased mortality in Turkish COVID-19 patients

Year 2023, Volume: 36 Issue: 2, 175 - 181, 31.05.2023

Zeynep Mercancı Can Ilgın Sehnaz Olgun Yıldızelı Derya Kocakaya Baran Balcan Buket Erturk Sengel Sait Karakurt Emel Eryuksel

https://doi.org/10.5472/marumj.1302440

Abstract

Objective: Coagulopathy is thought to play an important role in the development of severe COVID-19. High D-dimer levels have been
reported in Chinese cohort studies. However, ethnicity has significant implications for thrombotic risk. Our aim in this study is to
determine the effect of D-dimer measurements on disease prognosis and mortality in Turkish patients with COVID-19.
Patients and Methods: The study was designed retrospectively. Patients over the age of 18 who were admitted to our hospital were
included in the study.
Results: The study included 226 patients. According to the World Health Organization staging, 75(33.2%) patients, according to the
staging of Siddiqi et al., 67 (29.7%) patients progressed. In the ROC analysis performed to predict mortality, AUC value for D-dimer
was found to be 82.25% (95%CI 74.8%-89.71%). When the cut-off value for D-dimer was accepted as ≥3.25mg/L, specificity was
94.15%, correctly classified rate 88.5%, positive likelihood ratio as (LR):5.69, negative LR:0.71.
Conclusion: As a result, similar to the Chinese cohorts, elevated D-dimer measurements increase disease progression and mortality
in Turkish patients with COVID-19. D-dimer levels of 3.25 mg/L and above, strongly determine the risk of increased mortality in the
Turkish Caucasian ethnic group.

Keywords

COVID-19, D-dimer, Mortality, Ethnicity

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