Mesenteric panniculitis: Prevalence, imaging findings, relation with malignancy, comparison with control group and six-year follow-up

Year 2024, Volume: 37 Issue: 3, 305 - 310, 30.10.2024

Erdem Yılmaz , Muhammet Göktaş

https://doi.org/10.5472/marumj.1573460

Abstract

Objective: Objective: To investigate the prevalence of mesenteric panniculitis (MP), imaging findings, its relationship with malignancy,
development of malignancy in follow-up and make a comparison with the control group.
Patients and Methods: A total of 3196 multidetector computed tomography (CT) scans were evaluated retrospectively in terms of MP.
CT findings of MP, accompanying benign and malignant pathologies were examined. Two consecutive patients who matched by age,
gender, and abdominal diameter were included in the control group. A comparison was made between the MP and control groups
concerning malignancy and new malignancy development in the up to 6 years follow-up.
Results: One hundred and sixty-three MP cases and 326 control cases were included to the study. The most common CT findings
of MP were increased density of mesenteric fat, pseudomass appearance, and lymph nodes within the pseudomass. 59.5% (n: 97)
of the MP group and 58.3% (n: 190) of the control group were associated with malignancy (p: 0.77). The most common malignities
were colorectal cancer (n: 21, 12.2%) in the MP group, and lung cancer (n: 40, 12.2%) in the control group. During follow-up, new
malignities were detected 9.2% (n: 11) in the MP group and 6.3% (n: 8) in the control group (p: 0.37). Lung cancer (n: 3, 27.3%) in the
MP group and colorectal cancer (n: 2, 25%) in the control group were the most frequently seen cancer type (p: 0.09).
Conclusion: Mesenteric panniculitis prevalence is 5.1%. When the MP group was compared with the control group, there was no
significant accompanying malignancy and no significant new cancer development was observed.08

Keywords

Abdomen, Body CT, Follow-up, Mesenteric panniculitis, Oncologic imaging

References

• Gogebakan O, Albrecht T, Osterhoff MA, Reimann A. Is mesenteric panniculitis truely a paraneoplastic phenomenon? A matched pair analysis. Eur J Radiol 2013; 82:1853-9. doi: 10.1016/j.ejrad.2013.06.023
• Van Putte-Katier N, van Bommel EF, Elgersma OE, Hendriksz TR. Mesenteric panniculitis: prevalence, clinicoradiological presentation and 5-year follow-up. Br J Radiol 2014; 87: 20140451. doi: 10.1259/bjr.20140451
• Protin-Catteau L, Thiéfin G, Barbe C, Jolly D, Soyer P, Hoeffel C. Mesenteric panniculitis: review of consecutive abdominal MDCT examinations with a matched-pair analysis. Acta Radiol 2016; 57: 1438-44. doi: 10.1177/028.418.5116629829
• Daskalogiannakis M, Voloudaki A, Prassopoulos P et al. CT evaluation of mesenteric panniculitis: prevalence and associated diseases. AJR Am J Roentgenol 2000; 174: 427–31. doi: 10.2214/ajr.174.2.1740427
• Coulier B. Mesenteric panniculitis. Part 2: prevalence and natural course: MDCT prospective study. J BR-BTR 2011; 94: 241–6.
• McLaughlin PD, Philippone A, Maher MM. The ‘‘misty mesentery’’: mesenteric panniculitis and its mimics. Am J Roentgenol 2013; 200: 116–23. doi: 10.2214/AJR.12.8493
• Canyigit M, Koksal A, Akgoz A, Kara T, Sarisahin M, Akhan O. Multidetector-row computed tomography findings of sclerosing mesenteritis with associated diseases and its prevalence. Jpn J Radiol 2011; 29: 495–502. doi: 10.1007/ s11604.011.0587-5
• Wilkes A, Griffi N, Dixon L, Dobbs B, Frizelle FA. Mesenteric panniculitis: a paraneoplastic phenomenon? Dis Colon Rectum 2012; 55: 806–9. doi: 10.1097/DCR.0b013e318252e286
• Smith ZL, Sifuentes H, Deepak P, Ecanow DB, Ehrenpreis ED. Relationship between mesenteric abnormalities on computed tomography and malignancy: clinical findings and outcomes of 359 patients. J Clin Gastroenterol 2013; 47: 409-14. doi: 10.1097/MCG.0b013e318.270.3148
• Badet N, Sailley N, Briquez C, Paquette B, Vuitton L, Delabrousse É. Mesenteric panniculitis: still an ambiguous condition. Diagn Interv Imaging 2015; 96: 251-7. doi: 10.1016/j.diii.2014.12.002
• Corwin MT, Smith AJ, Karam AR, Sheiman RG. Incidentally detected misty mesentery on CT: risk of malignancy correlates with mesenteric lymph node size. J Comput Assist Tomogr 2012; 36: 26-9. doi: 10.1097/RCT.0b013e3182436c4d
• Cross AJ, McCormicj JJ, Griffin N, Dixon L, Dobbs B, Frizelle FA. Malignancy and mesenteric panniculitis. Colorectal Dis 2016; 18: 322-7. doi: 10.1111/codi.13154
• Ehpenpreis ED, Roginsky G, Gore RM. Clinical significance of mesenteric panniculitis-like abnormalities on abdominal computerized tomography in patients with malignant neoplasms. Worl J Gastroenterol 2016; 22: 10601-8. doi: 10.3748/wjg.v22.i48.10601
• Soyer P, Hoeffel C, Zins M. Mesenteric panniculitis: more research is needed. Diagn Interv Imaging 2015; 96: 225–6. doi: 10.1016/j.diii.2015.02.003
• Buchwald P, Diesing L, Dixon L et al. Cohort study of mesenteric panniculitis and its relationship to malignancy. Br J Surg 2016; 103: 1727-30. doi: 10.1002/bjs.10229
• Horton KM, Lawler LP, Fishman EK. CT findings in sclerosing mesenteritis (panniculitis): spectrum of disease. Radiographics 2003; 23: 1561-7. doi: 10.1148/rg.110.303.5010
• Eze VN, Halligan S. Mesenteric panniculitis: a clinical conundrum. Br J Radiol 2023; 96: 20211369. doi: 10.1259/ bjr.20211369
• Ghanem N, Pache G, Bley T, Kotter E, Langer M. MR findings in a rare case of sclerosing mesenteritis of the mesocolon. J Magn Reson Imaging 2005; 21: 632-6. doi: 10.1002/jmri.20280
• Sulbaran M, Chen FK, Farraye FA, Hashash JG. A Clinical Review of Mesenteric Panniculitis. Gastroenterol Hepatol (N Y). 2023; 19: 211-8. PMID: 37705847; PMCID: PMC10496345.