Lung Immune Prognostic Index (LIPI): Prognostic predictor for patients with extensive-stage small-cell lung cancer

Year 2025, Volume: 38 Issue: 1, 24 - 28, 29.01.2025

Nargiz Majidova , Mustafa Seyyar , Ali Kaan Güren , Erkam Kocaaslan , Muhammed Fatih Kırcalı , Pınar Erel Yeşim Ağyol , Mustafa Alperen Tunç , Burak Paçacı , Vedat Bayoğlu

https://doi.org/10.5472/marumj.1627671

Abstract

Objective: Extensive-stage small-cell lung cancer (ES-SCLC) is an aggressive malignancy with a poor prognosis, for which prognostic
factors are being investigated. In this study, we aimed to evaluate the prognostic significance of the Lung Immune Prognostic Index
(LIPI) in ES-SCLC patients.
Patients and Methods: Our retrospective study evaluated 60 ES-SCLC patients who were followed-up and treated between 2014 and
2022 and whose data could be accessed. Demographic characteristics, treatments and laboratory parameters (lactate dehydrogenase,
white blood cell, neutrophil, lymphocyte) were collected from patients’ files and electronic system of our institution. Patients were
divided into 3 groups (LIPI 0, LIPI 1 and LIPI 2).
Results: The worst survival outcome was in LIPI 2. Median progression-free survival (PFS) was 7.7 months for LIPI 0; 5.6 months for
LIPI 1 and 5.4 months for LIPI 2 (p = 0.001). Median overall survival (OS) was 19.7 months, 10.2 months and 7.7 months for LIPI 0,
LIPI 1 and LIPI 2, respectively (p = 0.001). In both univariate and multivariate analyses, LIPI was found to be an independent negative
prognostic factor (p = 0.001).
Conclusion: Lung Immune Prognostic Index is a potentially valuable prognostic marker in ES-SCLC patients. It is thought to be
helpful in individualized treatment decisions for ES-SCLC patients. However, further comprehensive multicenter studies are necessary
to confirm our results.

Keywords

Small-cell lung cancer, Lung Immune Prognostic Index, Progression-free survival, Overall survival

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