Formulation technologies of orally fast disintegrating tablets

Abstract

ABSTRACT: Methods to improve patient’s compliance have always attracted scientists towards
the development of new drug delivery systems. Among them, orally fast disintegratings
tablets (FDTs), have acquired an important place in the drug market by overcoming
previously encountered administration problems and contributing to extension of patent life.
FDTs have the unique property of rapidly disintegrating and/or dissolving and releasing the
drug as soon as they come in contact with saliva. Therefore, these tablets are very practical
for the patient population that include bed ridden, dysphagic, geriatric or pediatric and phychic
patients.
This article focuses on the technologies available and the advances made so far in the field
of fabrication of FDTs along with their advantages and limitations.
KEY WORDS: orally fast disintegrating tablets, formulation technologies of orally fast disintegrating
tablets

Keywords

• -

Ağızda hızlı çözünen tabletlerin formülasyon teknolojileri

Abstract

Hasta uyuncunu kolaylaştıracak metodların geliştirilmesi araştırmacıları yeni ilaç taşıyıcı sistemleri araştırmaya yönlendirmiştir. Bunlar arasında ağızda hızlı çözünen tabletler (FDTs), uygulama problemlerini aşmada ve patent süresinin uzatılmasına bulundukları katkı ile ilaç piyasasında önemli bir yer kazanmışlardır. FDT’ler tükrük ile temasta hızlı çözünme ve etkin madde salımına başlama özelliğine sahiptir. Bu nedenle, yutma güçlüğü çeken, yatağa bağımlı, geriatrik ve pediatrik hasta popülasyonu açısından son derece pratik kullanıma sahip tabletlerdir.Bu çalışma, hızlı çözünen tabletlerin teknolojileri ile üretimlerinde şimdiye kadar kaydedilen gelişmeler ile birlikte üretim yöntemlerinin avantajları ve sınırlandırılmaları üzerine odaklanmaktadır

Keywords

• ağızda hızlı çözünen tabletler, ağızda hızlı çözünen tabletlerin formülasyon teknolojileri

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