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Synthesis and pharmacological evaluation of isoxazole derivatives containing 1,2,4-triazole Moiety

Year 2012, Volume: 16 Issue: 2, 134 - 140, 07.03.2014

Shantaram Khanage Popat Mohite Ramdas Pandhare Appala Raju

Abstract

Keywords

Isoxazole antimicrobial antimycobacterial

References

  • Al-Soud YA, Al-Masoudi NA and Ferwanah AE. Synthesis and properties of new substituted 1,2,4-triazoles: Potential antitumor agents. Bioorg Med Chem 2003; 11: 1701-8.
  • Rao G, Rajasekran S, Attimarad M. Synthesis and Antimicro- bial activity of Some 5-phenyl-4-substituted amino-3-mer- capto (4H) 1,2,4-triazoles. Indian J Pharm Sci 2000; 6: 475-7.
  • Lazarevic M, Dimova V, Molnar GD, Kakurinov V, Col- anceska RK. Synthesis of some N1-aryl/heteroarylami- nomethyl/ethyl-1,2,4-triazoles and their antibacterial and antifungal activities. Heterocycl Comm 2001; 7: 577-82.
  • Chimirri A, Bevacqua F, Gitto R, Quartarone S, Zappala M, Sarro DA, Maciocco L, Biggo G, Sarro GD. Synthesis and anticonvulsant activity of new 1-H-triazolo[4,5-c] [2,3]benzodiaze-pines. Med Chem Res 1999; 9: 203-12.
  • Hunashal RD, Ronad PM, Maddi VS, Satyanarayana D, Kamadod MA. Synthesis, anti-inflammatory and anal- gesic activity of 2-[4-(substituted benzylideneamino)-5- (substitutedphenoxymethyl)-4H-1,2,4-triazol-3-yl-thio] acetic acid derivatives. Arabian J Chem 2011; 1-9.
  • Jalilian AR, Sattari S, Bineshmarvasti M, Shafiee A, Daneshtalab M. Synthesis and in vitro antifungal and cy- totoxicity evaluation of thiazolo-4H-1,2,4-triazoles and 1,2-thiadiazolo-4H-1,2,4-triazoles-thiazoles-1,2,3-thiadi- azoles. Arch Der Pharmazie 2000; 333: 347–54.
  • Lingappa B, Girisha KS, Balakrishna Kalluraya, Rai NS, Kumari NS. Regioselective reaction: Novel Mannich bases derived from 3-(4,6-disubstituted-2-thiomethyl)3- amino-5-mercapto-1,2,4-triazoles and their antimicrobial properties. Indian J Chem 2008; 47B: 1858-64.
  • Kane MJ, Dudley MW, Sorensen MS, Miller FP. Synthe- sis of 1,2,4-Dihydro-3H-1,2,4-triazole-3-thiones as poten- tial antidepressant agents. J Med Chem 1988; 31: 1253-8.
  • Husain MI, Amir M, Singh E. Synthesis and anti-tuber- cular activities of [5-(2 furyl)-1,2,4-triazoles-3yl thio] ace- hydrazide derivatives. Indian J Chem 1987; 26B: 2512-54.
  • Xiao Z, Waters NC, Woodard CL, Li PK. Design and synthesis of pfmrk inhibitors as potential antimalarial agents. Bioorg Med Chem Lett 2001; 11: 2875-8.
  • Deliwala CV, Mhasalkar MY, Shah MH, Pilankar PD, Nikam ST, Anantanarayan KG. Synthesis and hypogly- caemic activity of 3-aryl(or pyridyl)-5-alkyl amino-1,3,4, Thiadiazole and some sulfonyl ureas derivatives of 4H- 1,2,4 triazoles. J Med Chem 1971; 14: 1000-3.
  • Santos MM, Faria N, Iley J, Coles SJ, Hursthouse MB, Martins ML, Moreira R. Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and an- tifungal activity of naphtho[2,3-d]isoxazole-4,9-diones. Bioorg Med Chem Lett 2010; 20: 193-5.
  • Ravi SL, Nitinkumar SS, Ravindra RK, Imtiyaz MK La- mani RS, Shetty NS, Kamble RR, Khazi IA. Synthesis and antimicrobial studies of novel methylene bridged ben- zisoxazolyl imidazo[2,1-b][1,3,4]thiadiazole derivatives. Eur J Med Chem 2009; 44: 2828-33.
  • Kamal A, Reddy JS, Ramaiah MJ, Dastagiri D, Bhar- athi EV, Azhar MA, Sultana F, Pushpavalli SN, Pal- Bhadra M, Juvekar A, Sen S, Zingde S. Design, syn- thesis and biological evaluation of 3,5-diaryl-isoxa- zoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents. Eur J Med Chem 2010; 45: 3924-37.
  • Jayashankar B, Rai KM, Baskaran N, Sathish HS. Synthe- sis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammato- ry and analgesic agents. Eur J Med Chem 2009; 44: 3898- 3902.
  • Kini SG, Bhat AR, Bryant B, Williamson JS, Dayan FE. Synthesis, antitubercular activity and docking study of novel cyclic azole substituted diphenyl ether derivatives. Eur J Med Chem 2009; 44: 492-500.
  • Mazzei M, Balbil A, Sottofattoril E, Garzogliol R, Montis AD, Corrias S, Colla PL. Synthesis of new 3,5disubsti- tuted isoxazoles with specific anti-group B rhinovirus activity in vitro. Eur J Med Chem 1993; 28: 669-74.
  • Barcelo´ M, Ravina E, Masaguer CF, Domı´nguez E, Areias FM, Brea J and Loza MI. Synthesis and binding affinity of new pyrazole and isoxazole derivatives as po- tential atypical antipsychotics. Bioorg Med Chem Lett 2007; 17: 4873-77.
  • Kumar A, Maurya RA, Sharma S, Ahmad P, Singh AB, Tamrakar AK, Srivastava AK. Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti- hyperglycemic and lipid lowering agents. Bioorg Med Chem 2009; 17: 5285-92.
  • Gibbons S, Ohlendorf B, Jhonsen I. The genus Hyperi- cum-A valuable resource of anti-Staphylococcal leads. Fitoterapia 2002; 73: 300-4.

Synthesis and pharmacological evaluation of isoxazole derivatives containing 1,2,4-triazole Moiety

Year 2012, Volume: 16 Issue: 2, 134 - 140, 07.03.2014

Shantaram Khanage Popat Mohite Ramdas Pandhare Appala Raju

Abstract

References

  • Al-Soud YA, Al-Masoudi NA and Ferwanah AE. Synthesis and properties of new substituted 1,2,4-triazoles: Potential antitumor agents. Bioorg Med Chem 2003; 11: 1701-8.
  • Rao G, Rajasekran S, Attimarad M. Synthesis and Antimicro- bial activity of Some 5-phenyl-4-substituted amino-3-mer- capto (4H) 1,2,4-triazoles. Indian J Pharm Sci 2000; 6: 475-7.
  • Lazarevic M, Dimova V, Molnar GD, Kakurinov V, Col- anceska RK. Synthesis of some N1-aryl/heteroarylami- nomethyl/ethyl-1,2,4-triazoles and their antibacterial and antifungal activities. Heterocycl Comm 2001; 7: 577-82.
  • Chimirri A, Bevacqua F, Gitto R, Quartarone S, Zappala M, Sarro DA, Maciocco L, Biggo G, Sarro GD. Synthesis and anticonvulsant activity of new 1-H-triazolo[4,5-c] [2,3]benzodiaze-pines. Med Chem Res 1999; 9: 203-12.
  • Hunashal RD, Ronad PM, Maddi VS, Satyanarayana D, Kamadod MA. Synthesis, anti-inflammatory and anal- gesic activity of 2-[4-(substituted benzylideneamino)-5- (substitutedphenoxymethyl)-4H-1,2,4-triazol-3-yl-thio] acetic acid derivatives. Arabian J Chem 2011; 1-9.
  • Jalilian AR, Sattari S, Bineshmarvasti M, Shafiee A, Daneshtalab M. Synthesis and in vitro antifungal and cy- totoxicity evaluation of thiazolo-4H-1,2,4-triazoles and 1,2-thiadiazolo-4H-1,2,4-triazoles-thiazoles-1,2,3-thiadi- azoles. Arch Der Pharmazie 2000; 333: 347–54.
  • Lingappa B, Girisha KS, Balakrishna Kalluraya, Rai NS, Kumari NS. Regioselective reaction: Novel Mannich bases derived from 3-(4,6-disubstituted-2-thiomethyl)3- amino-5-mercapto-1,2,4-triazoles and their antimicrobial properties. Indian J Chem 2008; 47B: 1858-64.
  • Kane MJ, Dudley MW, Sorensen MS, Miller FP. Synthe- sis of 1,2,4-Dihydro-3H-1,2,4-triazole-3-thiones as poten- tial antidepressant agents. J Med Chem 1988; 31: 1253-8.
  • Husain MI, Amir M, Singh E. Synthesis and anti-tuber- cular activities of [5-(2 furyl)-1,2,4-triazoles-3yl thio] ace- hydrazide derivatives. Indian J Chem 1987; 26B: 2512-54.
  • Xiao Z, Waters NC, Woodard CL, Li PK. Design and synthesis of pfmrk inhibitors as potential antimalarial agents. Bioorg Med Chem Lett 2001; 11: 2875-8.
  • Deliwala CV, Mhasalkar MY, Shah MH, Pilankar PD, Nikam ST, Anantanarayan KG. Synthesis and hypogly- caemic activity of 3-aryl(or pyridyl)-5-alkyl amino-1,3,4, Thiadiazole and some sulfonyl ureas derivatives of 4H- 1,2,4 triazoles. J Med Chem 1971; 14: 1000-3.
  • Santos MM, Faria N, Iley J, Coles SJ, Hursthouse MB, Martins ML, Moreira R. Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and an- tifungal activity of naphtho[2,3-d]isoxazole-4,9-diones. Bioorg Med Chem Lett 2010; 20: 193-5.
  • Ravi SL, Nitinkumar SS, Ravindra RK, Imtiyaz MK La- mani RS, Shetty NS, Kamble RR, Khazi IA. Synthesis and antimicrobial studies of novel methylene bridged ben- zisoxazolyl imidazo[2,1-b][1,3,4]thiadiazole derivatives. Eur J Med Chem 2009; 44: 2828-33.
  • Kamal A, Reddy JS, Ramaiah MJ, Dastagiri D, Bhar- athi EV, Azhar MA, Sultana F, Pushpavalli SN, Pal- Bhadra M, Juvekar A, Sen S, Zingde S. Design, syn- thesis and biological evaluation of 3,5-diaryl-isoxa- zoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents. Eur J Med Chem 2010; 45: 3924-37.
  • Jayashankar B, Rai KM, Baskaran N, Sathish HS. Synthe- sis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammato- ry and analgesic agents. Eur J Med Chem 2009; 44: 3898- 3902.
  • Kini SG, Bhat AR, Bryant B, Williamson JS, Dayan FE. Synthesis, antitubercular activity and docking study of novel cyclic azole substituted diphenyl ether derivatives. Eur J Med Chem 2009; 44: 492-500.
  • Mazzei M, Balbil A, Sottofattoril E, Garzogliol R, Montis AD, Corrias S, Colla PL. Synthesis of new 3,5disubsti- tuted isoxazoles with specific anti-group B rhinovirus activity in vitro. Eur J Med Chem 1993; 28: 669-74.
  • Barcelo´ M, Ravina E, Masaguer CF, Domı´nguez E, Areias FM, Brea J and Loza MI. Synthesis and binding affinity of new pyrazole and isoxazole derivatives as po- tential atypical antipsychotics. Bioorg Med Chem Lett 2007; 17: 4873-77.
  • Kumar A, Maurya RA, Sharma S, Ahmad P, Singh AB, Tamrakar AK, Srivastava AK. Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti- hyperglycemic and lipid lowering agents. Bioorg Med Chem 2009; 17: 5285-92.
  • Gibbons S, Ohlendorf B, Jhonsen I. The genus Hyperi- cum-A valuable resource of anti-Staphylococcal leads. Fitoterapia 2002; 73: 300-4.
There are 20 citations in total.

Details

Primary Language English
Journal Section Articles
Authors

Shantaram Khanage This is me

Popat Mohite This is me

Ramdas Pandhare This is me

Appala Raju This is me

Publication Date March 7, 2014
Published in Issue Year 2012 Volume: 16 Issue: 2

Cite

APA Khanage, S., Mohite, P., Pandhare, R., Raju, A. (2014). Synthesis and pharmacological evaluation of isoxazole derivatives containing 1,2,4-triazole Moiety. Marmara Pharmaceutical Journal, 16(2), 134-140. https://doi.org/10.12991/mpj.93924
AMA Khanage S, Mohite P, Pandhare R, Raju A. Synthesis and pharmacological evaluation of isoxazole derivatives containing 1,2,4-triazole Moiety. Marmara Pharm J. March 2014;16(2):134-140. doi:10.12991/mpj.93924
Chicago Khanage, Shantaram, Popat Mohite, Ramdas Pandhare, and Appala Raju. “Synthesis and Pharmacological Evaluation of Isoxazole Derivatives Containing 1,2,4-Triazole Moiety”. Marmara Pharmaceutical Journal 16, no. 2 (March 2014): 134-40. https://doi.org/10.12991/mpj.93924.
EndNote Khanage S, Mohite P, Pandhare R, Raju A (March 1, 2014) Synthesis and pharmacological evaluation of isoxazole derivatives containing 1,2,4-triazole Moiety. Marmara Pharmaceutical Journal 16 2 134–140.
IEEE S. Khanage, P. Mohite, R. Pandhare, and A. Raju, “Synthesis and pharmacological evaluation of isoxazole derivatives containing 1,2,4-triazole Moiety”, Marmara Pharm J, vol. 16, no. 2, pp. 134–140, 2014, doi: 10.12991/mpj.93924.
ISNAD Khanage, Shantaram et al. “Synthesis and Pharmacological Evaluation of Isoxazole Derivatives Containing 1,2,4-Triazole Moiety”. Marmara Pharmaceutical Journal 16/2 (March 2014), 134-140. https://doi.org/10.12991/mpj.93924.
JAMA Khanage S, Mohite P, Pandhare R, Raju A. Synthesis and pharmacological evaluation of isoxazole derivatives containing 1,2,4-triazole Moiety. Marmara Pharm J. 2014;16:134–140.
MLA Khanage, Shantaram et al. “Synthesis and Pharmacological Evaluation of Isoxazole Derivatives Containing 1,2,4-Triazole Moiety”. Marmara Pharmaceutical Journal, vol. 16, no. 2, 2014, pp. 134-40, doi:10.12991/mpj.93924.
Vancouver Khanage S, Mohite P, Pandhare R, Raju A. Synthesis and pharmacological evaluation of isoxazole derivatives containing 1,2,4-triazole Moiety. Marmara Pharm J. 2014;16(2):134-40.