An approach to the intelligent drug delivery systems: Thermo-responsive membrane for pulsatile drug delivery

Abstract

ABSTRACT: In this study, the potential use of thermotropic liquid crystals as a responsive
release system was investigated. Cholesteryl oleyl carbonate liquid crystal (COC) has been
embedded in nylon membranes by using vacuum filtration methods. In vitro drug release
studies were performed by using a fluid/fluid diffusion cell. Sodium salicylate as a model
drug penetration study was performed in nylon membrane with or without COC that is prepared
at 25 and 37°C. Also the penetration studies were performed by repeatedly exchanging
the temperature cycle (10, 25, 37°C) of the water bath at predetermined intervals. It was
observed that COC and temperature have effects on the penetration of sodium salicylate. At
37 °C, the penetration rate of sodium salicylate was found higher than 25 °C and 10 °C, respectively.
Also, the penetration amount of sodium salicylate has changed as pulsatile drug
delivery in the presence of COC. As a result, according to the patients’ requirements, it
seems that the penetration rate and profile can be adjusted by developing pulsatile drug
delivery as a new system.
KEYWORDS: Cholesteryl oleyl carbonate, nylon membrane, pulsatile drug delivery,
sodium salicylate

Keywords

• Cholesteryl oleyl carbonate, nylon membrane, pulsatile drug delivery, sodium salicylate

An approach to the intelligent drug delivery systems: Thermo-responsive membrane for pulsatile drug delivery

Abstract

Bu çalışmada termotropik katı kristallerin uyarıcı salım sistemleri olarak potansiyel kullanımı araştırılmıştır. Kolesteril oleil karbonat vakum filtrasyon yöntemiyle naylon membranlara emdirilmiştir. İn vitro ilaç penetrasyon çalışmaları sıvı/sıvı difüzyon hücresi kullanılarak yapılmıştır. Model ilaç olarak kullanılan sodyum salisilatın kolesteril oleil karbonat içeren ve içermeyen naylon membranlardan penetrasyon çalışmaları belirli zaman aralıklarında, 10, 25 ve 37°C sıcaklık değişim döngüsü sağlanan su banyosunda yapılmıştır. Elde edilen veriler, kolesteril oleil karbonatın ve sıcaklığın sodyum salisilatın penetrasyonu üzerine etkileri olduğunu göstermiştir. 37 °C’de sodyum salisilatın penetrasyon hızı sırayla 25 ve 10 °C’ye göre daha yüksek bulunmuştur. Ayrıca sodyum salisilatın penetrasyon hızı kolesteril oleil karbonat varlığında pulsatil (basamaklı) ilaç uygulaması gibi değişim göstermiştir. Sonuç olarak, hasta ihtiyacına göre, ilaç penetrasyon hızı yeni sistemler olan pulsatil ilaç uygulamalarının geliştirilmesiyle ayarlanabilir

Keywords

• ANAHTAR KELİMELER: Kolesteril oleil karbonat, naylon membran, pulsatil ilaç uygulamaları, sodyum salisilat

References

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