A comparison study of anti food allergy of plane tree leaves extract with the chemical drug therapy in affected dogs

Abstract

A comparison study of anti food allergy of plane tree leaves extract with the chemical drug therapy in affected dogs

Abstract

Food allergy includes an overreaction of the immune system to certain foods or substances that trigger the immune system become confused. The purpose of this study was to evaluate the effect of oral administration of plantain leaf extract on immunity against food allergies in dogs. This study performed on 12 dogs and the dogs were divided into 3 groups. In 3 groups, 2 times a day for 5 days 10Grmy turmeric tablet was administered to food allergies occur in all categories. To first group twice daily, for 5 days, in each time 100cc oral plantain extract administered. In second group, prednisolone acetate used instead of plantain extract for 5 days (according to the dose of 2 mg/kg every 24 hours). And in third group (control) no medication used. Blood samples took for hematology and immunology experiments at days 0, 5 and 10 and the amount of blood was divided into two equal parts, and for hematology tests and to measure IgE immune factors and percentage and number of phagocytosis was sent to faculty lab. The result showed that in three groups comparison, during the recovery (post- treatment) Eos, IgE and Germ amount in Leaf extract group has no significant change in appropriation to control group. The amount of these factors in comparison with the Corton group had significant change (p<0.05), and other factors did not change significantly during treatment (p<0.05). Moreover, comparing two groups of Corton and sycamore, there is significantly better changes in IgE and Eos factors in the plantain leaves group. Therefore, mentioned factors indicate a favorable effect of plantain leaf extract in removing the symptoms of food allergy in dogs.

Keywords

• Corticosteroids, Dog, Food allergy, Immune system, Plantain leaf extract

References

1. Roger, H. Allergy - General Overview. Patient. 2015, 39, 1-6
2. Asturias, J., Ibarrola, I., Eraso, E., et al. The major Platanus acerifolia pollen allergen Pla a 1 has sequence homology to invertase inhibitors. Clin. Exp. Allergy. 2003. 33(7), 978-985.
3. Bousquet, J., Hejjaoui, A., Becker, W.M., et al. Clinical and immunologic reactivity of patients allergic to grass pollens and to multiple pollen species. I. Clinical and immunologic characteristics. J. Allergy. Clin. Immunol. 1991. 87(3), 737-746.
4. Carretero, A.P., Juste, P.S., Garcia, G.F., et al. Allergenic pollens and pollinosis in the city of Burgos. Alergol. Inmunol. Clin. 2005. 20(3), 90-94.
5. Belver, M.T., Caballero, M.T., Contreras, J., et al. Associations among pollen sensitizations from different botanical species in patients living in the northern area of Madrid. J. Investig. Allergol. Clin. Immunol. 2007. 17(3), 157-159.
6. Hejjaoui, A., Ferrando, R., Dhivert, H., et al. Systemic reactions occurring during immunotherapy with standardized pollen extracts. J. Allergy Clin. Immunol. 1992. 89(5), 925-933.
7. Gomez-Flores, R., Calderon, C.L., Scheibel, L.W., et al. Immunoenhancing properties of Plantago major leaf extract. Phytother. Res. 2000. 14(8), 617-622.
8. Samuelsen, A.B. The traditional uses, chemical constituents and biological activities of Plantago major L. A review. J. Ethnopharmacol. 2000. 71(1-2), 1-21.

9. Nixon, K.C., Poole, J.M., 2003. Revision of the Mexican and Guatemalan species of Platanus (Platanaceae). Lundellia. 6, 103-137.
10. Pourkhabbaz, A., Rastin, N., Olbrich, A., et al. Influence of environmental pollution on leaf properties of urban plane trees, Platanus orientalis L. Bull Environ Contam Toxicol. 2010. 85:251-255.
11. Ebn-e Sina, A., 1988. Ghanoon dar teb. Vol. 2. Tehran: Soroosh Press, pp. 119-120.
12. Zargari, A., 1990. Medicinal plants. Vol. 4. Tehran: Tehran University Publications, pp. 469-470.
13. Tonekaboni, S.M.M., 2007.Tohfatol momenin. Tehran: Nashr-e Shahr, p. 200.
14. Biringanine, G., Vray, B., Vercruysse, V., et al. Polysaccharides extracted from the leaves of Plantago palmata Hook.f. induce nitric oxide and tumor necrosis factor-alpha production by interferon-gamma-activated macrophages. Nitric Oxide. 2005. 12(1), 1-8.
15. Zubair, M., Ekholm, A., Nybom, H., et al. Effects of Plantago major L. leaf extracts on oral epithelial cells in a scratch assay. J. Ethnopharmacol. 2012. 141(3), 825-830.
16. Palanichamy, S., Nagarajan, S. Analgesic activity of Cassia alata leaf extract and kaempferol 3-O-sophoroside. J. Ethnopharmacol. 1990. 29, 73-78.
17. Parveen, Z., Deng, Y., Saeed, M.K., et al. Anti-inflammatory and analgesic activities of Thesium chinense Turcz extracts and its major flavonoids, kaempferol and kaempferol-3-O-glucoside.Thesium. chinense. 2007. 127, 1275-1279.
18. Chirumbolo, S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm. Allergy Drug Targets. 2010. 9, 263-285.
19. Da Cunha, F.M., Duma, D., Assreuy, J., et al. Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties. Free Readical Res. 2004. 38, 1241-1253.
20. Norata, G.D., Marchesi, P., Passamonti, S., et al. Anti-inflammatory and anti-atherogenic effects of catechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice. Atherosclerosis. 2007. 191, 265-271.