Garcinia atroviridis – A review on phytochemicals and pharmacological properties

Year 2017, , 38 - 47, 20.09.2016

Muhammad Taher Hanisuhana Hamidon Deny Susanti Zainul Amiruddin Zakaria

https://doi.org/10.12991/marupj.259879

Abstract

Garcinia atroviridis or commonly named as ‘Asam Gelugur’ among locals is extensively used as flavouring agent to provide sour sensation. Apart from flavouring agent, G. atroviridisis also used in many ways to promote health traditionally. Lab-based investigations of the plant reported many interesting potential of anti-oxidant, anti-microbial, anti-fungal, anti-obesity and lipid metabolism, cytotoxicity, anti-inflammatory, anti-malarial and anti-nicotine stress activities of G. atroviridis. This article discusses the G. atroviridis plant in aspect of its chemical constituents and bioactivities; in vitro and in vivo as well the clinical test made on this plant despite the limited data available. It is also an effort to update G. atroviridis data on its phytochemical and pharmacological data of the plant in the recent 15 years.      

 

Keywords

Garcinia atroviridis, hydroxycitric acid, antioxidant, antimicrobial, antiinflammatory, cytotoxic, antihyperlipidaemia

Garcinia atroviridis’in fitokimyasal ve farmakolojik özellikleri

Abstract

Garcinia atroviridis ya da yerel
adıyla ‘Asam Gelugur’ ekşi  tadı
nedeniyle lezzet verici olarak kullanılmaktadır. Bu  özelliğinin yanında G.atroviridis, geleneksel
tedavide de  insan sağlığına olumlu
etkileri nedeniyle kullanılmaktadır.  Yapılan
araştırmalarda, bitkinin; antioksidan, antimikrobiyel,  antifungal, anti-obezite ve lipid
metabolizması düzenleyici,  antienflamatuvar,
antimalariyal, nikotin stresini ortadan  kaldırıcı
ve sitotoksik özellikleri çalışılmıştır. Bu makale  kapsamında G.atroviridis’in içerdiği kimyasal
bileşenler ve  biyolojik özellikleri
incelenmiş, in vitro ve in vivo çalışmalara 
ek olarak sınırlı sayıdaki klinik çalışma hakkında da bilgi  verilmiştir. Bu çalışmada, son 15 yılda
G.atroviridis’in  fitokimyasal ve
farmakolojik özellikleri ile ilgili yapılan 
araştırmaların derlenmesi ile G.atroviridis hakkında güncel bir  kaynak oluşturulması amaçlanmıştır.  

Keywords

Garcinia atroviridis, hidroksisitrik asit, antioksidan, antimikrobiyel, antienflamatuvar, sitotoksik, antihiperlipidemik

References

• Lim TK. Garcinia atroviridis. In Edible Medicinal And Non-Medicinal Plants: Fruits. 2012; 2: 21-28.
• Tandon P, Abrol YP, Kumaria S. Biodiversity and its significance. IK International, New Delhi 2007; 280.
• Dweck D. A review of Asam Gelugor (Garcinia atroviridis) Griff ex T Aders
• (a) Achmadi SS. The potency of potassium hydroxycitrate derived from gelugur fruit (Garcinia atroviridis) in reducing body weight and cholesterol levels in rats. Hayati (Indonesia) 2001; 8: 23-26.
• (b) Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK. Chemistry and biochemistry of (−)-hydroxycitric acid from Garcinia. J. Agric. Food Chem 2002; 50: 10-22.
• (c) Kumar S, Sharma S, Chattopadhyay SK. Rapid and sensitive HPLC-PDA method for simultaneous identification and quantification of dietary weight reducing compound hydroxy citric acid lactone and chemo preventive compounds isoxanthochymol and xanthochymol in Garcinia indica. Int Food Res J 2013; 20: 397-402.
• Ferrara L. The Garcinia cambogia in phytotreatment of obesity: Activities of the hydroxycitric acid. ESJ 2014; 10: 291-301.
• Jayaprakasha GK, Sakariah KK. Determination of (−) hydroxycitric acid in commercial samples of Garcinia cambogia extract by liquid chromatography with ultraviolet detection. J Liq Chrom Relat Tech 2000; 23: 915-923.
• Mackeen MM, Ali AM, Lajis NH, Kawazu K, Kikuzaki H, Nakatani N. Antifungal garcinia acid esters from the fruits of Garcinia atroviridis. Z. Naturforsch. C Bio. Sci 2002; 57: 291-295.
• Kosin J, Ruangrungsi N, Ito C, Furukawa H. A xanthone from Garcinia atroviridis. Phytochemistry 1998; 47: 1167-1168.
• Tisdale EJ, Kochman DA, Theodorakis EA. Total synthesis of atroviridin. Tetrahedron Lett 2003; 44: 3281–3284.
• Permana D, Lajis NH, Mackeen MM, Ali AM, Aimi N, Kitajima M, Takayama H. Isolation and bioactivities of constituents of the roots of Garcinia atroviridis. ‎J. Nat. Prod 2001; 64: 976–979.
• Permana D, Nordin HL, Khozirah S, Abdul MA, Mukram MM, Mariko K, Hiromitsu T, Norio A. A new prenylated hydroquinone from the roots of Garcinia atroviridis Griff ex T. Anders (Guttiferae) Z. Naturforsch. B Chem Sci 2003; 58: 332-335.
• Permana D, Abas F, Maulidiani, Shaari K, Stanslas J, Ali AM, Lajis NH. Atrovirisidone B, a new prenylated depsidone with cytotoxic property from the roots of Garcinia atroviridis. Z. Naturforsch. C Bio Sci 2005; 60: 523–526.
• Tan WN, Wong KC, Khairuddean M, Eldeen IM, Asmawi M, Sulaiman B. Volatile constituents of the fruit of Garcinia atroviridis and their antibacterial and anti‐inflammatory activities. Flavour Frag J 2012; 28: 2-9.
• Tan WN, Khairuddean M, Wong KC, Khaw KY, Vikneswaran M. New cholinesterase inhibitors from Garcinia atroviridis. Fitoterapia 2014; 97: 261-267.
• Mackeen MM, Ali AM, Lajis NH, Kawazu K, Hassan Z, Amran M, Habsah M, Mooi LY, Mohamed SM. Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders. J Ethnopharmacol 2000; 72: 395-402.
• Nursakinah I, Zulkhairi HA, Norhafizah M, Hasnah B, Razif D. Nutritional content and in vitro antioxidant potential of Garcinia atroviridis (Asam gelugor) leaves and fruits. Malaysian Journal of Nutrition 2012; 18: 363-371.
• Abdullah AR, Bakhari NA, Osman H. Study on the relationship of the phenolic, flavonoid and tannin content to the antioxidant activity of Garcinia atroviridis. Universal Journal of Applied Science 2013; 1: 95-100.
• Al‐Mansoub MA, Asmawi M, Murugaiyah V. Effect of extraction solvents and plant parts used on the antihyperlipidemic and antioxidant effects of Garcinia atroviridis: a comparative study. J Sci Food Agric 2013; 94: 1552-1558.
• Basri DF, Sharif R, Morat P, Latip J. Evaluation of antimicrobial activities of the crude extracts from Garcinia atroviridis and Solanum torvum. Malays J Med Sci 2005; 24: 233–238.
• Suwanmanee S, Kitisin T, Luplertlop N. In vitro screening of 10 edible Thai plants for potential antifungal properties. Evid Based Complement Alternat Med 2014; 2: 1-7.
• Syahida A, Israf DA, Permana D, Lajis NH, Khozirah S, Afiza AW, Khaizurin TA, Somchit MN, Sulaiman MR, Nasaruddin AA. Atrovirinone inhibits pro-inflammatory mediator release from murine macrophages and human whole blood. Immunol Cell Biol 2006; 84: 250-258.
• Israf DA, Tham CL, Syahida A, Lajis NH, Sulaiman MR, Mohamad AS, Zakaria ZA. Atrovirinone inhibits proinflammatory mediator synthesis through disruption of NF-κB nuclear translocation and MAPK phosphorylation in the murine monocytic macrophage RAW 264.7. Phytomedicine 2010; 17: 732-739.
• Ong CY, Ling SK, Ali RM, Chee CF, Samah ZA, Ho AS, Teo SH, Lee HB. Systematic analysis of in vitro photo-cytotoxic activity in extracts from terrestrial plants in Peninsula Malaysia for photodynamic therapy. J Photochem Photobiol B 2009; 96: 216-222.
• Mackeen MM, Mooi LY, Amran M, Mat N, Lajis NH, Ali AM. Noncytotoxic and antitumour-promoting activities of garcinia acid esters from Garcinia atroviridis Griff. ex T. Anders (Guttiferae). Evid Based Complement Alternat Med 2012; 5: 1-5.
• Amran AA, Zaiton Z, Faizah O, Morat P. Effects of Garcinia atroviridis on serum profiles and atherosclerotic lesions in the aorta of guinea pigs fed a high cholesterol diet. Singapore Med J 2009; 50: 295-299.
• Amran AA, Zakaria Z, Othman F, Morat P. Effect of Garcinia atroviridis on oxidative stress and atherosclerotic changes in experimental guinea pigs. Am J Pharmacol Toxicol 2010; 5: 65-70.
• Dewi SRM, Hernita S. Efek ekstrak daun asan gelugur (Garcinia atroviridis Griff. T.Anders) terhadap Plasmodium berghei pada mencit. Majalah Farmasi Airlangga (Airlangga J Pharm) 2004; 4: 101–104.
• Zaiton Z, Rajikin MH, Noor Shahizan A, Morat P. The effect of Garcinia atroviridis on in-vitro embryo development in nicotine-treated mice. In: Abstract 20th scientific meeting of the Malaysian Society of Pharmacology and Physiology, Universiti Sains Malaysia,Penang, 25–27 Apr 2005, p 23
• Jantan I, Jumuddin FA, Saputri FC, Rahman K. Inhibitory effects of the extracts of Garcinia species on human low-density lipoprotein peroxidation and platelet aggregation in relation to their total phenolic contents. J Med Plant Res 2011; 5: 2699-2709.
• Roongpisuthipong C, Kantawan R, Roongpisuthipong W. Reduction of adipose tissue and body weight: effect of water soluble calcium hydroxycitrate in Garcinia atroviridis on the short term treatment of obese women in Thailand. Asia Pac J Clin Nutr 2007; 16: 25-29.