Preparation and characterization of herbal emulsion formulations

Abstract

St John’s wort extract (Hypericum perforatum L. aerial part

extract), marigold extract (Calendula officinalis L. flower

extract), wheat germ oil (Triticum vulgare Vill. germ oil)

and rose oil (Rosa damascena Mill. volatile oil) have antiinflammatory,

antimicrobial and wound healing properties. In

this study, it is aimed to prepare and characterize herbal topical

emulsion formulations for skin disorders with these herbal

extracts and oils. Initially the compatibility of herbal ingredients

was evaluated and the design of formulation as an emulsion was

studied. Then decided cream formulations were prepared as

o/w type emulsions. The formulations characterized via several

parameters such as; macroscopic and microscopic observations,

pH, electrical conductivity and rheological measurements.

The characterization of prepared three formulations revealed

acceptable properties while one of them had better applicability,

maintained its macroscopic stability in room conditions for 6

months, had appropriate pH and electrical conductivity values

and had pseudoplastic flow properties. As conclusion, a topical

emulsion formulation was prepared with appropriate properties.

Keywords

• Topical delivery,herbal formulations,emulsion,St John’s wort extract,marigold extract

References

1. 1. Wölfle U, Seelinger G, Schempp CM. Topical Application of St. John’s Wort (Hypericum perforatum). Planta Med 2014; 80: 109-20.
2. 2. Hamburger M, Adler S, Baumann D, Förg A, Weinreich B. Preparative purification of the major anti-inflammatory triterpenoid esters from Marigold (Calendula officinalis). Fitoterapia 2003; 74: 328-38.
3. 3. Roveroni-Favaretto LHD, Lodi KB, Almeida JD. Topical Calendula officinalis L. successfully treated exfoliative cheilitis: a case report. Cases J 2009; 23: 9077.
4. 4. Cosmetic Dermatology: Principles and Practice. Editor: Baumann L. The McGraw-Hill Companies, Inc. Chine. 2009, pp 294.
5. 5. Alğın Yapar E, İnal Ö, Erdal S. Design and in vivo evaluation of emulgel formulations including green tea extract and rose oil. Acta Pharm 2013: 63; 531-44.
6. 6. Ho KM. Proper choice of base of topical medicaments. Med Bull 2006; 11: 7-8.
7. 7. Dhase AS, Khadbadi SS, Saboo SS. Formulation and evaluation of vanishing herbal cream of crude drugs. AJEthno 2014; 1: 313-8.
8. 8. Gade J, More S, Bhalerao N. Formulation and characterization of herbal cream containing Fenugreek seed extracts. Int J Sci Res 2015; 5: 1-4.

9. 9. Mishra AP, Saklani S, Milella L, Tiwari P. Formulation and evaluation of herbal antioxidant face cream of Nardostachys jatamansi collected from Indian Himalayan region. Asian Pac J Trop Biomed 2014; 4: 679-82.
10. 10. Thakur L, Ghodasra U, Patel N, Dabhi M. Novel approaches for stability improvement in natural medicines. Pharmacogn Rev 2011; 5: 48-54.
11. 11. Shrikumar S, Maheshwari U, Sughanti A, Ravi TK. WHO guidelines for herbal drug standardization, 2006.
12. 12. Schmidts T, Dobler D, Guldan A-C, Paulus N, Runkel F. Multiple W/O/W emulsions—using the required HLB for emulsifier evaluation. Colloids Surf A Physicochem Eng Asp 2010; 372: 48–54.
13. 13. Tadros TF, Vincent B. Encyclopedia of Emulsion Technology Editor: Becher P. Marcel Dekker, New York. 1983.
14. 14. Lambers H, Piessens S, Bloem A, Pronk H, Finkel P. Natural skin surface pH is on average below 5, which is beneficial for its resident flora. Int J Cosmet Sci 2006; 28:359-70.
15. 15. Amit M, Stavans J. Stability of emulsions with nonadsorbing polymers. Langmuir 1996; 12: 301–4.
16. 16. Tanrıverdi ST, Özer Ö. Novel topical formulations of terbinafine-HCl for treatment of onychomycosis. Eur J Pharm Sci 2013;48:628-36.