Enhancement of solubility and dissolution of ibuprofen microparticle prepared by ultrasonic spray drying

Abstract

Ibuprofen (IBU) is one of the most commonly used nonsteroidal

anti-inflammatory drugs with high permeability

and low solubility. The aims of this research is to improve the

solubility and dissolution of the IBU by reducing particle size

using ultrasonic spray drying method and utilizing watersoluble

polymer (polyvinyl alcohol (PVA)) and surfactant

(sodium lauryl sulphate (SLS)) for particles formulation. The

results showed that increasing amount of PVA, smaller particle

size of as-prepared IBU-PVA-SLS was obtained, 6.3-fold smaller

than untreated IBU. The in vitro drug release study for simulated

gastric fluid without enzymes (0.1 N HCl or Buffer pH 1.2)

shows the dissolution of prepared IBU-PVA-SLS significantly

increase 2.4-fold higher than untreated IBU for dissolution

time of 30 minutes. While the solubility of the IBU-PVA-SLS

was increased 4.7-fold compare to untreated IBU. In general,

IBU possessing relatively high dissolution in intestinal fluid. In

contrast, the finding of recent investigation on dissolution of

IBU-PVA-SLS is significantly increase in gastric fluid, either due

to smaller particles size or PVA-SLS. Thus, despite the PVA and

SLS determine the particles formation during polymerization

yielding smaller particle size, they also responsible for effective

drug delivery system. It was concluded that PVA and SLS

in ultrasonic spray drying technique for IBU preparation

successfully reduces the particle size and effectively enhances

the solubility and dissolution rate of poorly water-soluble IBU

in 0.1 N HCl.

Keywords

• Ultrasonic spray drying,ibuprofen,polyvinyl alcohol,sodium lauryl sulphate,solubility,dissolution

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