Investigation of the effect of adjuvant chemotherapy in stage II colorectal cancers

Abstract

Colorectal cancer is the most prevalent and malignant

gastrointestinal cancer and the fourth most common cancer

around the world. Selection of the treatment method is based

on the staging of the disease. The aim of this interventional

study is to investigate the effect of adjuvant chemotherapy on

local recurrence, distant metastases, and three-year disease-free

lifespan in patients with stage II colorectal cancer.

This study conducted between 2001 and 2007 involved 40

patients with stage II colorectal cancer. Subsequent to surgery,

the adjuvant chemotherapy was performed employing the

FOLFOX4 diet therapy; the patients were further examined

every 3 months using tumor marker counts, sonography, CT

scan and colonoscopy for identification of any local recurrence

and metastasis. Finally, at the end of the third year and after

chemotherapy, the rates of local recurrence, metastasis and

survival of the patients were investigated.

The present study was conducted on 40 patients, 23 of whom

were male and the rest were female. After three years of

follow-up, 2 patients had local recurrence and 7 patients had

distant metastasis. All of the patients survived throughout the

three-year follow-up period.

In this study, the adjuvant chemotherapy in stage II colorectal

cancer led to significant overall survival and three-year diseasefree

survival.

Keywords

• Adjuvant chemotherapy; stage II colorectal cancer; overall survival.

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