An approach to the intelligent drug delivery systems: Thermo-responsive membrane for pulsatile drug delivery
Abstract
ABSTRACT: In this study, the potential use of thermotropic liquid crystals as a responsive
release system was investigated. Cholesteryl oleyl carbonate liquid crystal (COC) has been
embedded in nylon membranes by using vacuum filtration methods. In vitro drug release
studies were performed by using a fluid/fluid diffusion cell. Sodium salicylate as a model
drug penetration study was performed in nylon membrane with or without COC that is prepared
at 25 and 37°C. Also the penetration studies were performed by repeatedly exchanging
the temperature cycle (10, 25, 37°C) of the water bath at predetermined intervals. It was
observed that COC and temperature have effects on the penetration of sodium salicylate. At
37 °C, the penetration rate of sodium salicylate was found higher than 25 °C and 10 °C, respectively.
Also, the penetration amount of sodium salicylate has changed as pulsatile drug
delivery in the presence of COC. As a result, according to the patients’ requirements, it
seems that the penetration rate and profile can be adjusted by developing pulsatile drug
delivery as a new system.
KEYWORDS: Cholesteryl oleyl carbonate, nylon membrane, pulsatile drug delivery,
sodium salicylate
References
- Lin YY, Chen KS, Lin SY. Development and investigation of a thermo- responsive cholesteryl oleyl carbonateembedded membrane. J Control Rel 1996; 41: 163-70.
- Lin YY, Chen KS, Lin SY. Temperature effect on the thermal characteristics and drug penetrability of the thermally on-off switching membrane. Int J Pharm 1995; 124: 53Atlıhan E. Kolesteril oleil karbonat likit kristalinin kontrollü salım sistemlerinde kullanımının in vitro olarak araştırılması. Ege Üniversitesi Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi, İzmir. 2004.
- Lin SY, Lin YY, Chen KS. Permeation behavior of salbutamol sulphate through hydrophilic and hydrophobic membranes embedded by thermo-responsive cholesteryl oleyl carbonate. Pharmaceut Res 1996; 13: 914-9.
- Lin YY, Chen KS, Lin SY. Thermophysical properties of cholesteryl oleyl carbonate determined with microscopic FTIR/DSC system. J Chin Chem Soc 1995; 42: 865-8.
- D’ Emanuele A. Responsive polymeric drug delivery systems. Clin Pharmacokinet 1996; 31: 241-5.
- Watson SJ, D’Emanuele A, Gleeson HF. Liquid crystal embedded membranes for use in responsive release delivery systems. AAPS-Assoc. of American Pharmacists’ Symposium Book, San Francisco. 1998.
- Lin SY, Lin HL, Li MJ. Reproducibility of temperature response and long-term stability of thermo-responsive membrane prepared by adsorption of binary liquid crystals. J Membr Sci 2003; 225: 135-43.
- Lin SY, Chen KS, Lin YY. Ph of preparations affecting the on-off drug penetration behavior through the thermo-responsive liquid crystal embedded-membrane. J Control Rel 1998; 55: 13-20.
- Lin SY, Ho CJ, Li MJ. Precision and reproducibility of temperature response of a thermo-responsive membrane embedded by binary liquid crystals for drug delivery. J Control Rel 2001; 73: 293-301.
- Lin SY, Lin HL, Li MJ. Manufacturing affecting the drug delivery function of thermo-responsive membrane prepared by adsorption of binary liquid crystals. Eur J Pharm Sci 2002; 17: 153-60.
- Lin SY, Lin HL, Li MJ. Adsorption of binary liquid crystals on to cellulose membrane for thermo-responsive drug delivery. J Int Adsorp Soc 2002; 8: 197-202.
- Lin SY, Tseng HY, Li MJ. Phase studies and thermal stability of binary systems of cholesteric liquid crystals. Appl Phys A 2000; 70: 663-8.
- Lin SY, Lin YY, Chen KS. A thermo-switchable membrane for drug delivery. Drug Deliv 1995; 2: 123-7.
An approach to the intelligent drug delivery systems: Thermo-responsive membrane for pulsatile drug delivery
Abstract
Bu çalışmada termotropik katı kristallerin uyarıcı salım sistemleri olarak potansiyel kullanımı araştırılmıştır. Kolesteril oleil karbonat vakum filtrasyon yöntemiyle naylon membranlara emdirilmiştir. İn vitro ilaç penetrasyon çalışmaları sıvı/sıvı difüzyon hücresi kullanılarak yapılmıştır. Model ilaç olarak kullanılan sodyum salisilatın kolesteril oleil karbonat içeren ve içermeyen naylon membranlardan penetrasyon çalışmaları belirli zaman aralıklarında, 10, 25 ve 37°C sıcaklık değişim döngüsü sağlanan su banyosunda yapılmıştır. Elde edilen veriler, kolesteril oleil karbonatın ve sıcaklığın sodyum salisilatın penetrasyonu üzerine etkileri olduğunu göstermiştir. 37 °C’de sodyum salisilatın penetrasyon hızı sırayla 25 ve 10 °C’ye göre daha yüksek bulunmuştur. Ayrıca sodyum salisilatın penetrasyon hızı kolesteril oleil karbonat varlığında pulsatil (basamaklı) ilaç uygulaması gibi değişim göstermiştir. Sonuç olarak, hasta ihtiyacına göre, ilaç penetrasyon hızı yeni sistemler olan pulsatil ilaç uygulamalarının geliştirilmesiyle ayarlanabilir
Keywords
ANAHTAR KELİMELER: Kolesteril oleil karbonat naylon membran pulsatil ilaç uygulamaları sodyum salisilat
References
- Lin YY, Chen KS, Lin SY. Development and investigation of a thermo- responsive cholesteryl oleyl carbonateembedded membrane. J Control Rel 1996; 41: 163-70.
- Lin YY, Chen KS, Lin SY. Temperature effect on the thermal characteristics and drug penetrability of the thermally on-off switching membrane. Int J Pharm 1995; 124: 53Atlıhan E. Kolesteril oleil karbonat likit kristalinin kontrollü salım sistemlerinde kullanımının in vitro olarak araştırılması. Ege Üniversitesi Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi, İzmir. 2004.
- Lin SY, Lin YY, Chen KS. Permeation behavior of salbutamol sulphate through hydrophilic and hydrophobic membranes embedded by thermo-responsive cholesteryl oleyl carbonate. Pharmaceut Res 1996; 13: 914-9.
- Lin YY, Chen KS, Lin SY. Thermophysical properties of cholesteryl oleyl carbonate determined with microscopic FTIR/DSC system. J Chin Chem Soc 1995; 42: 865-8.
- D’ Emanuele A. Responsive polymeric drug delivery systems. Clin Pharmacokinet 1996; 31: 241-5.
- Watson SJ, D’Emanuele A, Gleeson HF. Liquid crystal embedded membranes for use in responsive release delivery systems. AAPS-Assoc. of American Pharmacists’ Symposium Book, San Francisco. 1998.
- Lin SY, Lin HL, Li MJ. Reproducibility of temperature response and long-term stability of thermo-responsive membrane prepared by adsorption of binary liquid crystals. J Membr Sci 2003; 225: 135-43.
- Lin SY, Chen KS, Lin YY. Ph of preparations affecting the on-off drug penetration behavior through the thermo-responsive liquid crystal embedded-membrane. J Control Rel 1998; 55: 13-20.
- Lin SY, Ho CJ, Li MJ. Precision and reproducibility of temperature response of a thermo-responsive membrane embedded by binary liquid crystals for drug delivery. J Control Rel 2001; 73: 293-301.
- Lin SY, Lin HL, Li MJ. Manufacturing affecting the drug delivery function of thermo-responsive membrane prepared by adsorption of binary liquid crystals. Eur J Pharm Sci 2002; 17: 153-60.
- Lin SY, Lin HL, Li MJ. Adsorption of binary liquid crystals on to cellulose membrane for thermo-responsive drug delivery. J Int Adsorp Soc 2002; 8: 197-202.
- Lin SY, Tseng HY, Li MJ. Phase studies and thermal stability of binary systems of cholesteric liquid crystals. Appl Phys A 2000; 70: 663-8.
- Lin SY, Lin YY, Chen KS. A thermo-switchable membrane for drug delivery. Drug Deliv 1995; 2: 123-7.
Details
| Primary Language | English |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | March 7, 2014 |
| Published in Issue | Year 2013 Volume: 17 Issue: 3 |
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