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Protective effects of Nigella sativa against hypertension-induced oxidative stress and cardiovascular dysfunction in rats

Year 2012, Volume: 16 Issue: 2, 141 - 149, 07.03.2014

Abstract

References

  • Textor SC, Lerman L. Renovascular hypertension and ischemic nephropathy.Am J Hypertens 2010; 23:1159-69.
  • Laursen JB, Rajagopalan S, Galis Z, Tarpey M, Freeman BA, Harrison DG.. Role of superoxide in angiotensin-II- induced but not catecholamine-induced hypertension. Circulation 1997; 95:588–93.
  • Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxi- dase activity in cultured vascular smooth muscle cells. Circ Res 1994; 74:1141-8.
  • Minuz P, Patrignani P, Gaino S, Degan M, Menapace L, Tommasoli R, Seta F, Capone ML, Tacconelli S, Palatresi S, Bencini C, Del Vecchio C, Mansueto G, Arosio E, San- tonastaso CL, Lechi A, Morganti A, Patrono C. Increased oxidative stress and platelet activation in patients with hypertension and renovascular disease. Circulation 2002; 106:2800-5.
  • Chong AY, Blann AD, Lip GY. Assessment of endothe- lial damage and dysfunction: observations in relation to heart failure. QJM 2003; 96:253-67.
  • Chade AR, Rodriguez-Porcel M, Herrmann J, Zhu X, Grande JP, Napoli C, Lerman A, Lerman LO. Antioxi- dant intervention blunts renal injury in experimental renovascular disease. J Am Soc Nephrol 2004; 15: 958-66.
  • Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res 2003; 17:299-305.
  • Badary OA, Taha RA, Gamal el-Din AM, Abdel-Wahab MH. Thymoquinone is a potent superoxide anion scav- enger. Drug Chem Toxicol 2003; 26:87-98.
  • Erşahin M, Toklu HZ, Akakin D, Yuksel M, Yeğen BC, Sener G. The effects of Nigella sativa against oxidative in- jury in a rat model of subarachnoid hemorrhage. Acta Neurochir (Wien) 2011; 153: 333-41.
  • Helle F Vågnes ØB, Iversen BM. Angiotensin II-induced calcium signaling in the afferent arteriole from rats with two-kidney, one-clip hypertension. Am J Physiol Renal Physiol 2006; 291: F140-7.
  • Schiller NB Shah PM, Crawford M, DeMaria A, De- vereux R, Feigenbaum H, Gutgesell H, Reichek N, Sahn D, Schnittger I, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiogra- phy. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two- Dimensional Echocardiograms. J Am Soc Echocardiogr 1989; 2: 358-67.
  • Haklar G, Ulukaya-Durakbaşa C, Yüksel M, Daglı T, Yalcin AS. Oxygen radicals and nitric oxide in rat me- senteric ischemia-reperfusion: modulation by L-arginine and N-nitro-L-arginine methyl ester. Clin Exp Pharma- col Physiol 1998; 25:908-12.
  • Beuge JA, Aust SD. Microsomal lipid peroxidation. Meth Enzymol 1978; 52: 302-11.
  • Beutler E. Glutathione in red blood cell metabolism. A Manuel of Biochemical Methods. New York, Grune & Stratton, 1975, pp.112-4.
  • Reading HW, Isbir T. The role of cation-activated ATPas- es in transmitter release from the rat iris. Q J Exp Physiol Cogn Med Sci 1980; 65:105-16.
  • Fiske CH, Subbarow Y. The colorimetric determination of phosphorus. J Biol Chem 1925; 66:375-400.
  • Lowry OH RN, Farr AL, Randall RJ. Protein Measure- ments with the folin phenol reagent. J Biol Chem 1951; 193:265-75.
  • Bai Y, Hui R. Dimethylarginine dimethylaminohy- drolase (DDAH)--a critical regulator of hypertensive left ventricular hypertrophy? Med Hypotheses 2008; 70:962-6.
  • Leiper J, Nandi M, Torondel B, Murray-Rust J, Malaki M, O’Hara B, Rossiter S, Anthony S, Madhani M, Selwood D, Smith C, Wojciak-Stothard B, Rudiger A, Stidwill R, McDonald NQ, Vallance P. Disruption of methyl- arginine metabolism impairs vascular homeostasis. Nat Med 2007; 13:198-203.
  • Rajagopalan S, Kurz S, Munzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG. Angiotensin II-medi- ated hypertension in the rat increases vascular superox- ide production via membrane NADH/NADPH oxidase activation: contribution to alterations of vasomotor tone. J Clin Invest 1996; 97:1916–23.
  • Kako K, Kato M, Matsuoka T, Mustapha A. Depression of membrane-bound Na+-K+-ATPase activity induced by free radicals and by ischemia of kidney. Am J Physiol 1988; 254:C330-7.
  • Ross, D. Glutathione, free radicals and chemotherapeutic agents. Mechanisms of free-radical induced toxicity and glutathione-dependent protection. Pharmacol Ther 1988; 37:231-49.
  • Vaziri ND, Wang XQ, Oveisi F, Zhou XJ. Induction of oxidative stress by glutathione depletion causes se- vere hypertension in normal rats. Hypertension 2000; 36:142–6.
  • Erşahin M, Sehirli O, Toklu HZ, Süleymanoglu S, Eme- kli-Alturfan E, Yarat A, Tatlidede E, Yeğen BC, Sener G. Melatonin improves cardiovascular function and amel- iorates renal, cardiac and cerebral damage in rats with renovascular hypertension. J Pineal Res 2009; 47:97-106.
  • Mansour SM, Bahgat AK, El-Khatib AS, Khayyal MT. Ginkgo biloba extract (EGb 761) normalizes hypertension in 2K, 1C hypertensive rats: Role of antioxidant mecha- nisms, ACE inhibiting activity and improvement of en- dothelial dysfunction. Phytomedicine. 2011; 18:641-7.
  • Abdelmeguid NE, Fakhoury R, Kamal SM, Al Wafai RJ. Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozo- tocin-induced diabetic rats. J Diabetes 2010; 2:256-66.
  • El-Abhar HS, Abdallah DM, Saleh S. Gastroprotective activity of Nigella sativa oil and its constituent, thymoqui- none, against gastric mucosal injury induced by ischae- mia/reperfusion in rats. J Ethnopharmacol 2003; 84:251-8.
  • Badary OA, Abdel-Naim AB, Abdel-Wahab MH, Hama- da FM. The influence of thymoquinone on doxorubicin- induced hyperlipidemic nephropathy in rats. Toxicology 2000; 143:219-26.
  • Khattab MM, Nagi MN. Thymoquinone supplementa- tion attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats. Phytother Res 2007; 21:410–4.
  • Ismail M, Al-Naqeep G, Chan KW. Nigella sativa thy- moquinone-rich fraction greatly improves plasma anti- oxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radic Biol Med 2010; 48:664-72.
  • Gradman AH, Alfayoumi F. From left ventricular hyper- trophy to congestive heart failure: management of hyper- tensive heart disease. Prog Cardiovasc Dis 2006; 48: 326–41.

Protective effects of Nigella sativa against hypertension-induced oxidative stress and cardiovascular dysfunction in rats

Year 2012, Volume: 16 Issue: 2, 141 - 149, 07.03.2014

Abstract

References

  • Textor SC, Lerman L. Renovascular hypertension and ischemic nephropathy.Am J Hypertens 2010; 23:1159-69.
  • Laursen JB, Rajagopalan S, Galis Z, Tarpey M, Freeman BA, Harrison DG.. Role of superoxide in angiotensin-II- induced but not catecholamine-induced hypertension. Circulation 1997; 95:588–93.
  • Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxi- dase activity in cultured vascular smooth muscle cells. Circ Res 1994; 74:1141-8.
  • Minuz P, Patrignani P, Gaino S, Degan M, Menapace L, Tommasoli R, Seta F, Capone ML, Tacconelli S, Palatresi S, Bencini C, Del Vecchio C, Mansueto G, Arosio E, San- tonastaso CL, Lechi A, Morganti A, Patrono C. Increased oxidative stress and platelet activation in patients with hypertension and renovascular disease. Circulation 2002; 106:2800-5.
  • Chong AY, Blann AD, Lip GY. Assessment of endothe- lial damage and dysfunction: observations in relation to heart failure. QJM 2003; 96:253-67.
  • Chade AR, Rodriguez-Porcel M, Herrmann J, Zhu X, Grande JP, Napoli C, Lerman A, Lerman LO. Antioxi- dant intervention blunts renal injury in experimental renovascular disease. J Am Soc Nephrol 2004; 15: 958-66.
  • Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res 2003; 17:299-305.
  • Badary OA, Taha RA, Gamal el-Din AM, Abdel-Wahab MH. Thymoquinone is a potent superoxide anion scav- enger. Drug Chem Toxicol 2003; 26:87-98.
  • Erşahin M, Toklu HZ, Akakin D, Yuksel M, Yeğen BC, Sener G. The effects of Nigella sativa against oxidative in- jury in a rat model of subarachnoid hemorrhage. Acta Neurochir (Wien) 2011; 153: 333-41.
  • Helle F Vågnes ØB, Iversen BM. Angiotensin II-induced calcium signaling in the afferent arteriole from rats with two-kidney, one-clip hypertension. Am J Physiol Renal Physiol 2006; 291: F140-7.
  • Schiller NB Shah PM, Crawford M, DeMaria A, De- vereux R, Feigenbaum H, Gutgesell H, Reichek N, Sahn D, Schnittger I, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiogra- phy. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two- Dimensional Echocardiograms. J Am Soc Echocardiogr 1989; 2: 358-67.
  • Haklar G, Ulukaya-Durakbaşa C, Yüksel M, Daglı T, Yalcin AS. Oxygen radicals and nitric oxide in rat me- senteric ischemia-reperfusion: modulation by L-arginine and N-nitro-L-arginine methyl ester. Clin Exp Pharma- col Physiol 1998; 25:908-12.
  • Beuge JA, Aust SD. Microsomal lipid peroxidation. Meth Enzymol 1978; 52: 302-11.
  • Beutler E. Glutathione in red blood cell metabolism. A Manuel of Biochemical Methods. New York, Grune & Stratton, 1975, pp.112-4.
  • Reading HW, Isbir T. The role of cation-activated ATPas- es in transmitter release from the rat iris. Q J Exp Physiol Cogn Med Sci 1980; 65:105-16.
  • Fiske CH, Subbarow Y. The colorimetric determination of phosphorus. J Biol Chem 1925; 66:375-400.
  • Lowry OH RN, Farr AL, Randall RJ. Protein Measure- ments with the folin phenol reagent. J Biol Chem 1951; 193:265-75.
  • Bai Y, Hui R. Dimethylarginine dimethylaminohy- drolase (DDAH)--a critical regulator of hypertensive left ventricular hypertrophy? Med Hypotheses 2008; 70:962-6.
  • Leiper J, Nandi M, Torondel B, Murray-Rust J, Malaki M, O’Hara B, Rossiter S, Anthony S, Madhani M, Selwood D, Smith C, Wojciak-Stothard B, Rudiger A, Stidwill R, McDonald NQ, Vallance P. Disruption of methyl- arginine metabolism impairs vascular homeostasis. Nat Med 2007; 13:198-203.
  • Rajagopalan S, Kurz S, Munzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG. Angiotensin II-medi- ated hypertension in the rat increases vascular superox- ide production via membrane NADH/NADPH oxidase activation: contribution to alterations of vasomotor tone. J Clin Invest 1996; 97:1916–23.
  • Kako K, Kato M, Matsuoka T, Mustapha A. Depression of membrane-bound Na+-K+-ATPase activity induced by free radicals and by ischemia of kidney. Am J Physiol 1988; 254:C330-7.
  • Ross, D. Glutathione, free radicals and chemotherapeutic agents. Mechanisms of free-radical induced toxicity and glutathione-dependent protection. Pharmacol Ther 1988; 37:231-49.
  • Vaziri ND, Wang XQ, Oveisi F, Zhou XJ. Induction of oxidative stress by glutathione depletion causes se- vere hypertension in normal rats. Hypertension 2000; 36:142–6.
  • Erşahin M, Sehirli O, Toklu HZ, Süleymanoglu S, Eme- kli-Alturfan E, Yarat A, Tatlidede E, Yeğen BC, Sener G. Melatonin improves cardiovascular function and amel- iorates renal, cardiac and cerebral damage in rats with renovascular hypertension. J Pineal Res 2009; 47:97-106.
  • Mansour SM, Bahgat AK, El-Khatib AS, Khayyal MT. Ginkgo biloba extract (EGb 761) normalizes hypertension in 2K, 1C hypertensive rats: Role of antioxidant mecha- nisms, ACE inhibiting activity and improvement of en- dothelial dysfunction. Phytomedicine. 2011; 18:641-7.
  • Abdelmeguid NE, Fakhoury R, Kamal SM, Al Wafai RJ. Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozo- tocin-induced diabetic rats. J Diabetes 2010; 2:256-66.
  • El-Abhar HS, Abdallah DM, Saleh S. Gastroprotective activity of Nigella sativa oil and its constituent, thymoqui- none, against gastric mucosal injury induced by ischae- mia/reperfusion in rats. J Ethnopharmacol 2003; 84:251-8.
  • Badary OA, Abdel-Naim AB, Abdel-Wahab MH, Hama- da FM. The influence of thymoquinone on doxorubicin- induced hyperlipidemic nephropathy in rats. Toxicology 2000; 143:219-26.
  • Khattab MM, Nagi MN. Thymoquinone supplementa- tion attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats. Phytother Res 2007; 21:410–4.
  • Ismail M, Al-Naqeep G, Chan KW. Nigella sativa thy- moquinone-rich fraction greatly improves plasma anti- oxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radic Biol Med 2010; 48:664-72.
  • Gradman AH, Alfayoumi F. From left ventricular hyper- trophy to congestive heart failure: management of hyper- tensive heart disease. Prog Cardiovasc Dis 2006; 48: 326–41.
There are 31 citations in total.

Details

Primary Language English
Journal Section Articles
Authors

Nur Taşar This is me

Özer Şehirli This is me

Ömer Yiğiner This is me

Selami Süleymanoğlu This is me

Meral Yüksel This is me

Berrak Yeğen This is me

Göksel Şener This is me

Publication Date March 7, 2014
Published in Issue Year 2012 Volume: 16 Issue: 2

Cite

APA Taşar, N., Şehirli, Ö., Yiğiner, Ö., Süleymanoğlu, S., et al. (2014). Protective effects of Nigella sativa against hypertension-induced oxidative stress and cardiovascular dysfunction in rats. Marmara Pharmaceutical Journal, 16(2), 141-149. https://doi.org/10.12991/mpj.46202
AMA Taşar N, Şehirli Ö, Yiğiner Ö, Süleymanoğlu S, Yüksel M, Yeğen B, Şener G. Protective effects of Nigella sativa against hypertension-induced oxidative stress and cardiovascular dysfunction in rats. J Res Pharm. March 2014;16(2):141-149. doi:10.12991/mpj.46202
Chicago Taşar, Nur, Özer Şehirli, Ömer Yiğiner, Selami Süleymanoğlu, Meral Yüksel, Berrak Yeğen, and Göksel Şener. “Protective Effects of Nigella Sativa Against Hypertension-Induced Oxidative Stress and Cardiovascular Dysfunction in Rats”. Marmara Pharmaceutical Journal 16, no. 2 (March 2014): 141-49. https://doi.org/10.12991/mpj.46202.
EndNote Taşar N, Şehirli Ö, Yiğiner Ö, Süleymanoğlu S, Yüksel M, Yeğen B, Şener G (March 1, 2014) Protective effects of Nigella sativa against hypertension-induced oxidative stress and cardiovascular dysfunction in rats. Marmara Pharmaceutical Journal 16 2 141–149.
IEEE N. Taşar, Ö. Şehirli, Ö. Yiğiner, S. Süleymanoğlu, M. Yüksel, B. Yeğen, and G. Şener, “Protective effects of Nigella sativa against hypertension-induced oxidative stress and cardiovascular dysfunction in rats”, J Res Pharm, vol. 16, no. 2, pp. 141–149, 2014, doi: 10.12991/mpj.46202.
ISNAD Taşar, Nur et al. “Protective Effects of Nigella Sativa Against Hypertension-Induced Oxidative Stress and Cardiovascular Dysfunction in Rats”. Marmara Pharmaceutical Journal 16/2 (March 2014), 141-149. https://doi.org/10.12991/mpj.46202.
JAMA Taşar N, Şehirli Ö, Yiğiner Ö, Süleymanoğlu S, Yüksel M, Yeğen B, Şener G. Protective effects of Nigella sativa against hypertension-induced oxidative stress and cardiovascular dysfunction in rats. J Res Pharm. 2014;16:141–149.
MLA Taşar, Nur et al. “Protective Effects of Nigella Sativa Against Hypertension-Induced Oxidative Stress and Cardiovascular Dysfunction in Rats”. Marmara Pharmaceutical Journal, vol. 16, no. 2, 2014, pp. 141-9, doi:10.12991/mpj.46202.
Vancouver Taşar N, Şehirli Ö, Yiğiner Ö, Süleymanoğlu S, Yüksel M, Yeğen B, Şener G. Protective effects of Nigella sativa against hypertension-induced oxidative stress and cardiovascular dysfunction in rats. J Res Pharm. 2014;16(2):141-9.

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