Synthesis and evaluation of antiviral, antitubercular and anticancer activities of some novel thioureas derived from 4-aminobenzohydrazide hydrazones

Year 2010, Volume: 14 Issue: 1, 13 - 20, 03.03.2014

Pelin Çıkla Güniz Küçükgüzel İlkay Küçükgüzel Sevim Rollas Erik De Clercq Christophe Pannecouque Graciela Andrei Robert Snoeck Fikrettin Şahin Ömer Bayrak

Abstract

ABSTRACT: A series of novel 1-[4-[[2-[(4-substituted phenyl)methylene]hydrazino]carbonyl]p
henyl]-3-substituted thiourea derivatives have been synthesized by the addition of substituted
aryl isothiocyanates to 4-amino-N’-[(4-substituted phenyl) methylene] benzohydrazide, which
was prepared by condensation of 4-aminobenzoic acid hydrazide with 4-fluorobenzaldehyde
or 4-(trifluoromethyl)benzaldeyde. All synthesized compounds were evaluated in vitro against
HIV-1 (IIIB) and HIV-2 (ROD) strains in MT-4 cells, as well as other selected viruses such as
HSV-1, HSV-2, Coxsackie virus B4, Sindbis virus, human cytomegalovirus, and varicella-zoster
virus using HeLa, Vero, or HEL cell cultures. Antimycobacterial activity against Mycobacterium
tuberculosis H37 Rv was also evaluated. The anticancer activity and cytotoxicity screening of
the synthesized compounds were determined on A 549 and L 929 cell lines.
KEY WORDS: Hydrazones, Thioureas, Antiviral activity, Anticancer activity, Mycobacterium
tuberculosis H37Rv

Keywords

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Pelin Ç×kla1, û. Güniz Küçükgüzel1, şlkay Küçükgüzel1, Sevim Rollas1

Abstract

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