Development and statistical optimization of sustained release gastro retentive floating tablets of Cephalexin

Year 2016, Volume: 20 Issue: 2, 172 - 183, 06.03.2016

KAMBHAM Venkateswarlu , K.B Chandrasekhar

Abstract

Development and Statistical Optimization of Sustained Release Gastro Retentive Floating Tablets of Cephalexin

Abstract

The aim of present study was to formulate the sustained release floating tablets of Cephalexin (CPL) by direct compression method and optimized by Box-behnken Response Surface Methodology (RSM). A computer aided optimization technique was employed to investigate the formulation design by Box-behnken RSM (Design Expert Software version 8.0.7.1) to study the effect of the concentration of various polymer blends on the property of CPL gastroretentive floating tablets like floating lag time (FLT), cumulative percent drug release (%CDR). The independent variables investigated were polymeric concentrations (X1) and dependent variables were FLT (Y1), %CDR (Y2) in 0.1N HCl buffer at the end of 8 h. Results from precompression evaluation indicated that all the 17 and optimized formulation F18 were complied with the pharmacopoeial limits. The predicted value for FLT and %CDR obtained from software was compared with the experimental value of FLT and %CDR of optimized formulation F-18 and it was observed that the obtained experimental value was in very close agreement with the predicted value. The optimized formulation (F-18) gave good FLT and %CDR when compared to the 17 formulations.

Key words: Cephalexin: Design Expert Software; Floating tablets; Optimization; Response Surface Methodology.      

Keywords

Cephalexin, design expert software, Floating tablets, Optimization, response surface Methodology

References

• Amit KN, Ruma M, Biswarup D. Gastro retentive drug delivery systems: a review. Asian J Pharm Clin Res 2010; 3: 2-10.
• Sunil K, Faraz Jl, Meenu R, Saurabh S. Gastro Retentive Drug Delivery System: Features and Facts. Int J Res Pharm Biomed Sci 2012;3:125-136.
• Ravi Kumar Z, Snehalatha, Nagaraja TS, Yogananda R. Formulation, Evaluation and study of effect of hydrophilic polymers on release rate of Cephalexin floating tablets. Int J Drug Discov Herbal Res 2013;3:541-348.
• Jishnu V, Prabhakaran R1, Gilhotra RM. Formulation and evaluation of Cephalexin extended release matrix tablets using 32 factorial design. J Young Pharmacists 2011;3: 259-266.
• Radha Krishna N, Deepika B, Chinna Eswaraiah M. Formulation and in-vitro evaluation of floating matrix tablets of Cephalexin. Int J Pharm Chem Sci 2013;2:1519-1527.
• Mohammed AH, Yeswanth Reddy M, Maimuna A. Formulation and evaluation of gastro retentive effervescent floating matrix tablets of Cephalexin. J Drug Deliv Therap 2014;4:22-30.
• Sreenivasa Rao K, Rakesh RV, Dattatreya BU, Praveen SP, Karankumar VB. Development and evaluation of gastroretentive floating tablets of Cefpodoxime Proxetil. Int J Res Pharm Chem 2012;2: 46-53.
• Kamini V, Rajesh KS, Lalit LJ. Formulation and evaluation of floating microspheres of Cephalexin. Int J Pharm Sci Rev Res 2011;11: 69-75.
• Mohammed AH, Yeswanth Reddy M, Maimuna A. Formulation and evaluation of gastro retentive effervescent floating matrix tablets of Cephalexin. J Drug Del Ther 2014;4: 22-30.
• Shah D, Shah Y, Rampradhan M. Development and evaluation of controlled release diltiazem hydrochloride microparticles using cross-linked poly (vinyl alcohol). Drug Dev Ind Pharm 1997;23:567-74.
• Venkateswarlu K, Shanthi A. Formulation and evaluation of glipizide matrix. IOSR J Pharm Biol Sci 2012;2:17-23.
• Khan KA. The concept of dissolution efficiency. J Pharm Pharmacol 1975;27:48-9.
• Dave BS, Amin AF, Patel MM. Gastroretentive drug delivery system of ranitidine hydrochloride: Formulation and In-Vitro Evaluation. AAPS PharmSciTech 2004;5:77-82.
• Roy P, Shahiwala A. Statistical optimization of Ranitidine Hydrochloride floating pulsatile delivery system for chronotherapy of nocturnal acid breakthrough. Eur J Pharm Sci 2009;37:363-9.
• Rajeshwar KKA, Singh R, Vijay J. Mucoadhesive microspheres of famotidine: preparation characterization and in vitro evaluation. Int J Eng Sci Tech. 2010;2:1575-1580.
• Anil kumar JS, Arun NW, Manoj BP, Harinath NM. Formulation and In vitro evaluation of sustained release floating tablet of Cephalexin using hydrophilic polymers. Int J Pharm Sci 2010; 2: 58-65.
• Urmi D, Mohammad SH. Effects of release modifier on Carvedilol release from kollidon SR based matrix, Int Curr Pharm J 2012;1:186-192.
• Suvakanta D, Narasimhamurthy P, Lilakanthnath, Chaudhary P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 2010;67:217-233.
• Prajapati S.T, Patel LD and Patel DM. Gastric floating matrix tablets: design and optimization using combination of polymers. Acta Pharm 2008;58:221-9.
• Ulrike B, Roland B. In situ gelling, bioadhesive nasal inserts for extended drug delivery: In vitro characterization of a new nasal dosage form. Eur J Pharm Sci 2006;27:62-71.
• Viridena A, Wittgrenb B, Larsson A, Investigation of critical polymer properties for polymer release and swelling of HPMC matrix tablets. Eur J Pharm Sci 2009;36:297-309.