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Fatih Tok, Nagihan BeyhaN, Bedia kocyigiT-kaymakcioglu

Year 2016, Volume: 20 Issue: 2, 157 - 163, 10.03.2016

Fatih Tok Nagihan Beyhan Yalçın Erzurumlu Recep İlhan Petek Ballar Bedia Koçyiğit Kaymakçıoğlu

Abstract

Antiproliferative activity of some tautomeric hydrazones derived from chalcones

Year 2016, Volume: 20 Issue: 2, 157 - 163, 10.03.2016

Fatih Tok Nagihan Beyhan Yalçın Erzurumlu Recep İlhan Petek Ballar Bedia Koçyiğit Kaymakçıoğlu

Abstract

A new series of hydrazones synthesized from chalcones. Synthesized compounds have been characterized by IR, 1H-NMR and elemental analysis. Antiproliferative activity of compounds was investigated on Hela, A549, MCF7, HCC1937, MRC5 cells. All compounds exhibited cytotoxicity. Especially compounds 1b, 1c, 1f and 1i having 4-metylsulfonyl phenyl showed higher cytotoxicity against all of the cell lines compared to reference drug doxorubicin with low value of IC50=5,56-21,93 µM. The most active compounds 1b, 1c, 1f and 1i were analyzed for their effect on autophagic processes. HCC1937 cells were treated with these compounds at IC50 concentration for 24 hours. An immunoblotting assay was performed to analysis autophagy markers and total polyubiquitinated protein levels. Compounds 1b, 1c, 1f and 1i significantly increased the conversion of LC3-I to LC3-II at IC50 concentration. None of the tested compounds changed the level of total polyubiquitinated proteins.

Keywords: chalcones, hydrazones, antiproliferative activity

Keywords

chalcones hydrazones antiproliferative activity

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Details

Primary Language English
Journal Section Articles
Authors

Fatih Tok This is me

Nagihan Beyhan This is me

Yalçın Erzurumlu This is me

Recep İlhan This is me

Petek Ballar This is me

Bedia Koçyiğit Kaymakçıoğlu

Publication Date March 10, 2016
Published in Issue Year 2016 Volume: 20 Issue: 2

Cite

APA Tok, F., Beyhan, N., Erzurumlu, Y., İlhan, R., et al. (2016). Antiproliferative activity of some tautomeric hydrazones derived from chalcones. Marmara Pharmaceutical Journal, 20(2), 157-163. https://doi.org/10.12991/mpj.20162093956
AMA Tok F, Beyhan N, Erzurumlu Y, İlhan R, Ballar P, Koçyiğit Kaymakçıoğlu B. Antiproliferative activity of some tautomeric hydrazones derived from chalcones. J Res Pharm. February 2016;20(2):157-163. doi:10.12991/mpj.20162093956
Chicago Tok, Fatih, Nagihan Beyhan, Yalçın Erzurumlu, Recep İlhan, Petek Ballar, and Bedia Koçyiğit Kaymakçıoğlu. “Antiproliferative Activity of Some Tautomeric Hydrazones Derived from Chalcones”. Marmara Pharmaceutical Journal 20, no. 2 (February 2016): 157-63. https://doi.org/10.12991/mpj.20162093956.
EndNote Tok F, Beyhan N, Erzurumlu Y, İlhan R, Ballar P, Koçyiğit Kaymakçıoğlu B (February 1, 2016) Antiproliferative activity of some tautomeric hydrazones derived from chalcones. Marmara Pharmaceutical Journal 20 2 157–163.
IEEE F. Tok, N. Beyhan, Y. Erzurumlu, R. İlhan, P. Ballar, and B. Koçyiğit Kaymakçıoğlu, “Antiproliferative activity of some tautomeric hydrazones derived from chalcones”, J Res Pharm, vol. 20, no. 2, pp. 157–163, 2016, doi: 10.12991/mpj.20162093956.
ISNAD Tok, Fatih et al. “Antiproliferative Activity of Some Tautomeric Hydrazones Derived from Chalcones”. Marmara Pharmaceutical Journal 20/2 (February 2016), 157-163. https://doi.org/10.12991/mpj.20162093956.
JAMA Tok F, Beyhan N, Erzurumlu Y, İlhan R, Ballar P, Koçyiğit Kaymakçıoğlu B. Antiproliferative activity of some tautomeric hydrazones derived from chalcones. J Res Pharm. 2016;20:157–163.
MLA Tok, Fatih et al. “Antiproliferative Activity of Some Tautomeric Hydrazones Derived from Chalcones”. Marmara Pharmaceutical Journal, vol. 20, no. 2, 2016, pp. 157-63, doi:10.12991/mpj.20162093956.
Vancouver Tok F, Beyhan N, Erzurumlu Y, İlhan R, Ballar P, Koçyiğit Kaymakçıoğlu B. Antiproliferative activity of some tautomeric hydrazones derived from chalcones. J Res Pharm. 2016;20(2):157-63.

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