3D quantitative structure activity relationship of tetrahydroımıdazo [1,2-a] pyrimidine as antimıcrobial agents

Year 2017, Volume: 21 Issue: 3, 644 - 653, 23.06.2017

Sa Khedkar Js Patil Pm Sable

https://doi.org/10.12991/marupj.323296

Abstract

A series 24 tetrahydroimidazo[1,2-a] pyrimidine derivatives

were subjected to 3D quantitative structure activity relationship

for antimicrobial activity. Partial least square methodology was

utilized for the development of QSAR models. Six different

QSAR models have been generated for antimicrobial efficiency

of tetrahydroimidazo[1,2-a] pyrimidine derivatives against

three human pathogens. QSAR models revealed positive

influence of steric and electronic parameters on antimicrobial

potential - of tetrahydroimidazo[1,2-a] pyrimidine derivatives.

Keywords

Pyrimidine, QSAR, Partial least square

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