Anti-lipase activity for Portulaca oleracea, Urtica urens, Brassica napus and Lathyrus hierosolymitanus wild plants from Palestine

Year 2017, Volume: 21 Issue: 4, 828 - 836, 01.12.2017

Nidal Jaradat , Abdel Naser Zaıd Eyass Zuhair Zaghal

Abstract

Plants are used to the treatment and prevention of many of

metabolic, degenerative and cardiovascular diseases. Obesity

is one of the most common metabolic diseases which is

considered one of the global health problems. The present

study aimed to screen anti-lipase effect of Portulaca oleracea,

Urtica urens, Brassica napus and Lathyrus hierosolymitanus

traditional Palestinian medicinal wild plants. Anti-lipase

activity was measured by using porcine pancreatic lipase

inhibitory test which was established by using the UV-visible

spectrophotometer method, while orlistat (anti-obesity drug)

was used as a positive control reference. The porcine pancreatic

lipase inhibitory effect for organic and aqueous extracts of Urtica

urens were 157 μg/ml and 157.1 μg/ml, respectively. While the

anti-lipase IC50 value for the organic extract of P. oleracea was

262.03 μg/ml. In addition, the aqueous extracts of Brassica napus

and Portulaca oleracea have anti-lipase activity with the IC50

values 296.87 μg/ml and 417.62 μg/ml, respectively. Meanwhile,

Lathyrus hierosolymitanus both aqueous and organic extracts

were almost inactive. The results showed that Urtica urens,

Portulaca oleracea, and Brassica napus have anti-lipase activity,

which provided evidence for their folkloric use as functional

food and medicine. These three plants could be used as antilipase

agents in the pharmaceutical and nutritional industries

or may be used as fatty food additives in order to decrease the

absorption and digestion of fats from food.

Keywords

Obesity, pancreatic lipase enzyme, traditional plants

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